Structural characterization and anticancer potency of centipede oligopeptides in human chondrosarcoma cancer: inducing apoptosis

Abstract

CO-10 induced cell apoptosis with mitochondria dysfunction and caspases, ASK1-MAPKs pathway activation.

Peptide fractions from Sacha inchi induced apoptosis in HepG2 cells via P53 activation and a mitochondria‐mediated pathway

“…For example, the centipede oligopeptide-10 (CO-10) has been demonstrated to increase apoptosis in human chondrosarcoma cells via upregulation of the levels of cleaved PARP, cleaved-caspase-3 and cleaved-caspase-9. 28 Moreover, lunasin, a peptide that can be found in soy, barley, wheat and rye, has been proven to fight tumors through activating caspase-mediated mitochondria intrinsic apoptosis. 29 Caspases, in response to apoptotic signals, first activate initiator caspases to trigger the caspase cascade reaction, and then cleave specific substrates by activated execution caspases to cause apoptosis.…”

“…Peptides have been shown to trigger apoptosis by regulating apoptosis‐related protein. For example, the centipede oligopeptide‐10 (CO‐10) has been demonstrated to increase apoptosis in human chondrosarcoma cells via upregulation of the levels of cleaved PARP, cleaved‐caspase‐3 and cleaved‐caspase‐9 28 . Moreover, lunasin, a peptide that can be found in soy, barley, wheat and rye, has been proven to fight tumors through activating caspase‐mediated mitochondria intrinsic apoptosis 29 .…”