Structural characterization and chromosomal localization of the mouse cDNA and gene encoding the bone tyrosine phosphatase, mOST-PTP

Morrison, Daniel F.; Mauro, Laura J.

doi:10.1016/s0378-1119(00)00397-8

Cited by 16 publications

(15 citation statements)

References 33 publications

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“…We had generated mice lacking a tyrosine phosphatase expressed only in osteoblasts and Sertoli cells of the testis, hence its name, osteoblast testis-specific protein tyrosine phosphatase (OST-PTP) encoded by a gene termed Esp [20,21]. Importantly, whether the gene was deleted in all cells or in osteoblasts only, Esp−/− mice exhibited the same phenotype made of hypoglycemia, hyperinsulinemia, and increased glucose utilization by peripheral tissues [22••].…”

Section: Identification Of Osteocalcin As a Hormone Regulating Insulimentioning

confidence: 99%

An Overview of the Metabolic Functions of Osteocalcin

Wei

Karsenty

2015

Curr Osteoporos Rep

101

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A recent unexpected development of bone biology is that bone is an endocrine organ regulating a growing number of physiological processes. One of the functions regulated by bone through the hormone osteocalcin is glucose homeostasis. In this overview, we will explain why we hypothesized that bone mass and energy metabolism should be subjected to a coordinated endocrine regulation. We will then review the experiments that revealed the endocrine function of osteocalcin and the cell biology events that allow osteocalcin to become a hormone. We will also illustrate the importance of this regulation to understand whole-body glucose homeostasis in the physiological state and in pathological conditions. Lastly, we will mention epidemiological and genetic evidence demonstrating that this function of osteocalcin is conserved in humans.

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Section: Identification Of Osteocalcin As a Hormone Regulating Insulimentioning

confidence: 99%

An Overview of the Metabolic Functions of Osteocalcin

Wei

Karsenty

2015

Curr Osteoporos Rep

101

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show abstract

“…We had generated mice lacking a tyrosine phosphatase expressed only in osteoblasts and Sertoli cells of the testis, hence its name, osteoblast testis specific protein tyrosine phosphatase (OST-PTP) [21]. This receptor protein tyrosine phosphatase is encoded by a gene termed Esp [22]. Importantly, whether the gene was deleted in all cells or in osteoblasts only, Esp−/− mice exhibited the same phenotype made of hypoglycemia, hyperinsulinemia and increased glucose utilization by peripheral tissues [23].…”

Section: Identification Of Osteocalcin As a Hormone Regulating Insumentioning

confidence: 99%

An overview of the metabolic functions of osteocalcin

Wei

Karsenty

2015

Rev Endocr Metab Disord

151

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A recent unexpected development of bone biology is that bone is an endocrine organ contributing to the regulation of a number of physiological processes. One of the functions regulated by bone through osteocalcin, an osteoblast specific hormone, is glucose homeostasis. In this overview, we explain the rationale why we hypothesized that there should be a coordinated endocrine regulation between bone mass and energy metabolism. We then review the experiments that identified the endocrine function of osteocalcin and the cell biology events that allow osteocalcin to become a hormone. We also demonstrate the importance of this regulation to understand whole-body glucose homeostasis in the physiological state and in pathological conditions. Lastly we discuss the epidemiological and genetic evidence demonstrating that this function of osteocalcin is conserved in humans.

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“…These observations remained unexplained for some years until the same investigators, in the course of experiments in which they were ablating bone-specific proteins in mice, noted the opposite phenotype in mice null for Esp gene [78] , which encodes an osteotesticular protein tyrosine phosphatase (OST-PTP) that hampers glucose metabolism by inhibiting OC endocrine functions.…”

Section: How Bone Controls Energetic Metabolism: Ocmentioning

confidence: 99%

Energy metabolism and the skeleton: Reciprocal interplay

Amelio

2012

WJO

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The relation between bone remodelling and energy expenditure is an intriguing, and yet unexplained, challenge of the past ten years. In fact, it was only in the last few years that the skeleton was found to function, not only in its obvious roles of body support and protection, but also as an important part of the endocrine system. In particular, bone produces different hormones, like osteocalcin (OC), which influences energy expenditure in humans. The undercarboxylated form of OC has a reduced affinity for hydroxyapatite; hence it enters the systemic circulation more easily and exerts its metabolic functions for the proliferation of pancreatic β-cells, insulin secretion, sensitivity, and glucose tolerance. Leptin, a hormone synthesized by adipocytes, also has an effect on both bone remodelling and energy expenditure; in fact it inhibits appetite through hypothalamic influence and, in bone, stimulates osteoblastic differentiation and inhibits apoptosis. Leptin and serotonin exert opposite influences on bone mass accrual, but several features suggest that they might operate in the same pathway through a sympathetic tone. Serotonin, in fact, acts via two opposite pathways in controlling bone remodelling: central and peripheral. Serotonin product by the gastrointestinal tract (95%) augments bone formation by osteoblast, whereas brain-derived serotonin influences low bone mineral density and its decrease leads to an increase in bone resorption parameters. Finally, amylin (AMY) acts as a hormone that alters physiological responses related to feeding, and plays a role as a growth factor in bone.In vitro AMY stimulates the proliferation of osteoblasts, and osteoclast differentiation. Here we summarize the evidence that links energy expenditure and bone remodelling, with particular regard to humans.

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Structural characterization and chromosomal localization of the mouse cDNA and gene encoding the bone tyrosine phosphatase, mOST-PTP

Cited by 16 publications

References 33 publications

An Overview of the Metabolic Functions of Osteocalcin

An Overview of the Metabolic Functions of Osteocalcin

An overview of the metabolic functions of osteocalcin

Energy metabolism and the skeleton: Reciprocal interplay

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