Structural Characterization and Immunoenhancing Effects of a Polysaccharide from the Soft Coral Lobophytum sarcophytoides

Cao, Xianglin; Zhang, Qian; Zhu, Yehan; Li, Siju; Cai, Ying; Li, Pei; Liu, Deliang; Leng, Yun; Ye, Simin; Xu, Zengmei; Li, Hao; Shen, Baochun; Liao, Qiongfeng; Liu, Lan; Xie, Zenghong

doi:10.1007/s10126-022-10099-y

Cited by 2 publications

(1 citation statement)

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“…Seaweed and marine animals, such as corals and sea cows, produce mucus that contains polysaccharides. These polysaccharides may be involved in stimulating the immune system of other organisms [17][18][19][20][21][22][23] . Polysaccharides produced by star sh have also been reported to be involved in immunity of mouse models 24 .…”

Section: Discussionmentioning

confidence: 99%

Analysis of the positive effects of crown-of-thorns starfish on the growth and immune system of red sea bream

Miura

Ohta

Miyake

et al. 2023

Preprint

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The crown-of-thorns starfish (Acanthaster planci) feeds on corals, so extermination and other measures are used to protect ecosystems from this predation. However, red sea bream (Pagrus major) reared with crown-of-thorns starfish showed improved growth, increased phagocytic activity of leukocytes, and improved survival in a challenge test using Edwardsiella tarda, which is highly pathogenic to sea bream. These findings suggest that starfish mucus contains a substance that can improve disease resistance in red sea bream. This substance was isolated and identified using nitric oxide (NO) productivity of mouse-derived macrophage cells (RAW264) as an indicator. The immune-activating substance was identified to be a polymeric compound, possibly a polysaccharide. This substance was then purified, resulting in a molecule of molecular weight 1.81 x 105. The monosaccharides in the polysaccharide were identified and quantified, and l-fucose, d-arabinose, d-mannose, d-glucose, d-galactose, N-acetyl-d-glucosamine, and N-acetyl-d-galactosamine were detected. The purified polysaccharides were examined in the RAW264 cell line using antibodies against Toll-like receptors (TLRs) and were found to stimulate TLR4 – a receptor for pathogens – and activate the immune system. These results indicate that polysaccharides in starfish mucus have a positive effect on growth and immunity in fish.

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