Structural characterization and immunoregulatory mechanism of a low-molecular-weight polysaccharide from lotus root

Sun, Ying; Zhang, Mengjie; Jiang, Xueyu; Peng, Kaidi; Yi, Yang; Meng, Yan; Wang, Hongxun

doi:10.1016/j.ijbiomac.2024.135957

International Journal of Biological Macromolecules

2024

DOI: 10.1016/j.ijbiomac.2024.135957

|View full text |Cite

Structural characterization and immunoregulatory mechanism of a low-molecular-weight polysaccharide from lotus root

Ying Sun,

Mengjie Zhang,

Xueyu Jiang

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Unraveling the web of defense: the crucial role of polysaccharides in immunity

Shen,

Zhao,

Wang

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

The great potential of polysaccharides in immunological regulation has recently been highlighted in pharmacological and clinical studies. Polysaccharides can trigger immunostimulatory responses through molecular identification, intra- and intercellular communication via direct or indirect interactions with the immune system. Various immunostimulatory polysaccharides or their derivative compounds interacts at cellular level to boost the immune system, including arabinogalactans, fucoidans, mannans, xylans, galactans, hyaluronans, fructans, pectin and arabinogalactans, etc. These natural polysaccharides are derived from various plants, animals and microbes. A unique structural diversity has been identified in polysaccharides, while monosaccharides and glucosidic bonds mainly confer diverse biological activities. These natural polysaccharides improve antioxidant capacity, reduce the production of pro-inflammatory mediators, strengthen the intestinal barrier, influence the composition of intestinal microbial populations and promote the synthesis of short-chain fatty acids. These natural polysaccharides are also known to reduce excessive inflammatory responses. It is crucial to develop polysaccharide-based immunomodulators that could be used to prevent or treat certain diseases. This review highlights the structural features, immunomodulatory properties, underlying immunomodulatory mechanisms of naturally occurring polysaccharides, and activities related to immune effects by elucidating a complex relationship between polysaccharides and immunity. In addition, the future of these molecules as potential immunomodulatory components that could transform pharmaceutical applications at clinical level will also be highlighted.

show abstract

Unraveling the web of defense: the crucial role of polysaccharides in immunity

Shen,

Zhao,

Wang

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Structural characterization and immunoregulatory mechanism of a low-molecular-weight polysaccharide from lotus root

Cited by 1 publication

References 34 publications

Unraveling the web of defense: the crucial role of polysaccharides in immunity

Unraveling the web of defense: the crucial role of polysaccharides in immunity

Contact Info

Product

Resources

About