Structural characterization and molecular docking studies of biologically active platinum(II) and palladium(II) complexes of ferrocenyl Schiff bases

Synthesis, structural characterization, and in vitro biological activity studies of ternary metal complexes of 1,10‐phenanthroline and the anti‐inflammatory bromhexine drug

“…[17][18][19] The two bands in the spectra of the ternary complexes are moved to higher results, shifting the π-π* and n-π* and transition bands to, respectively, 213-275 and 262-391 nm. [17][18][19] Charge transfer may have caused the absorption bands in the spectra of the Cr(III) and Co(II) complexes at 416 and 391 nm, respectively, while the d-d transition of a metal ion can be explained by an absorption band in the Fe(III) complex at 507 nm. 20,21 There were three bands at 24,375, 21,770, and 14,738 cm À1 that could be seen in the Cr(III) complex's diffused reflectance spectrum.…”

“…An additional band seen at 373 nm is due to an electrical transition called n-π*, while the free 1,10-phenantholine had an absorption band at 289 nm that might be related to the pyridine and benzene ring π-π* transitions. [17][18][19] The two bands in the spectra of the ternary complexes are moved to higher results, shifting the π-π* and n-π* and transition bands to, respectively, 213-275 and 262-391 nm. [17][18][19] Charge transfer may have caused the absorption bands in the spectra of the Cr(III) and Co(II) complexes at 416 and 391 nm, respectively, while the d-d transition of a metal ion can be explained by an absorption band in the Fe(III) complex at 507 nm.…”

“…By studying anticancer activity difference against breast cancer (MCF-7 cell line) between using BHX with glycine and BHX with Phen mixed ligands and their transition metal complexes, it was found that [Cr(BHX)(Phen)(H 19 Also, the synthesized organometallic acetyl ferrocene imine ligand (HL) that was obtained by the direct condensation of 2-acetylferrocene with 2-aminothiophenol and its metal complexes of the first transition metal series was prepared, characterized, and screened as anticancer agents with different concentrations. It was observed that only Mn(II)-HL, Cu(II)-HL, Zn(II)-HL, and Cd(II)-HL complexes showed activity that showed IC 50 = 1.55 μg/mL, the latter compound was more reactive and could be recommended.…”

“…In four stages, the [Ni(BHX)(Phen)(H 2 O) 2 ]Cl 2 .6H 2 O complex's thermal deterioration occurred between 40 C and 1000 C. The first two phases were observed between 40 C and 320 C and correlated to the loss of seven water molecules (hydrated and coordinated), as well as one molecule of HCl, with a weight loss estimated at 19 Note: n* = number of decomposition steps. Abbreviations: BHX, bromhexine; Phen, 1,10-phenanthroline; TG, thermogravimetric analysis.…”

“…[Mn (BHX)(Phen)(H 2 O) 2 ]Cl 2 .2H 2 O had about 24 times activity than [Mn(BHX)(GLY) (H 2 O) 2 ]Cl complex, so 1,10-pheeneanthroline greatly increased the potency of anticancer effect than glycine amino acid 3. Fatma et al19 prepared two Schiff-based ligands and their Pt(II) and Pd(II) metal complexes and tested them against MCF-7 cell line. It was found that [Pd(L 2 )(H 2 O) Cl]ClÁ3H 2 O (IC 50 = 11.00 μg/mL), the lowest concentration from the tested compounds, was higher than [Mn (BHX)(Phen)(H 2 O) 2 ]Cl 2 .2H 2 O (IC 50 = 0.97 μg/mL), [Cu (BHX)(Phen)Cl(H 2 O)]Cl.H 2 O (IC 50 = 1.25 μg/mL), and [Cd(BHX)(Phen)(H 2 O) 2 ]Cl 2 .2H 2 O (IC 50 = 1.55 μg/mL).…”