Structural characterization, antifungal and cytotoxic profiles of quaternized heteropolysaccharide from Anadenanthera colubrina

Ribeiro, Fábio de Oliveira Silva; Araújo, Gisele Santos de; Mendes, Maria; Daboit, Tatiane Caroline; Brito, Lucas Moreira; Pessoa, Cláudia; Lima, Laís Ramos Monteiro de; Paula, Regina C.M. de; Bastos, Ruan Sousa; Rocha, Jefferson Almeida; Brito, Egil de; Oliveira, Thaísa Cardoso de; Oliveira, Antônia Carla de Jesus; Sobrinho, José Lamartine Soares; Leite, José de Souza de Almeida Roberto; Araújo, Alyne Rodrigues de; Silva, Durcilene Alves da

doi:10.1016/j.ijbiomac.2020.09.087

Cited by 18 publications

(4 citation statements)

References 63 publications

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“…The inclusion of quaternary ammonium compounds (QACs) in polymers can also represent a promising strategy for preparing antimicrobial materials. Many of these compounds have low toxicity, biocompatibility, and environmental stability [ 6 , 82 ]. Literature reports show that the biocidal activity of QACs is related to the length of the R (alkyl) chain,the greater this length, the greater the hydrophobicity that makes the compound compatible with the hydrophobic lipid bilayer of the microorganism's cytoplasmic membrane.…”

Section: Coating Strategies Using Polymeric Matricesmentioning

confidence: 99%

“…Generally, polymeric antimicrobial agents have the following advantages: (1) in general, they do not volatilize and are chemically stable; (2) the intended application temperature is the same as the storage; (3) its insolubility in water allows application in water disinfection processes; (4) the biomaterials do not permeate through the skin; (5) for the most part, their syntheses are easily controlled and economically viable [ 4 , 6 – 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Polymeric surfaces with biocidal action: challenges imposed by the SARS-CoV-2, technologies employed, and future perspectives

Castro

Costa

2021

J Polym Res

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The COVID-19 pandemic has demonstrated that hygiene habits reduce the spread of the SARS-CoV-2 virus on contaminated surfaces. In this context, compounds with biocidal properties can act as surface coatings, especially in hospital environments, a source of pathogenic microorganisms. Therefore, the purpose of this review was to report an overview of recent studies with biocidal agents, focusing on polymeric surface modification. Methods such as direct incorporation, direct deposition, and chemical deposition of the microbial agent on the polymeric surface and surface modification without a microbial agent were discussed. Despite several studies in the literature, antimicrobial materials still face challenges such as commercialization, material stability in post-processing, and guarantee of long cycles. Moreover, effectiveness, toxicity, and final cost must be balanced. We also discussed the concept of antiviral activity and the action mode of the materials. Inorganic, organic materials, nanocomposites, and biopolymers have been addressed as viral inhibitors of several diseases. Lastly, we explored the functional validation of polymeric surface through characterization techniques.

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Section: Coating Strategies Using Polymeric Matricesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polymeric surfaces with biocidal action: challenges imposed by the SARS-CoV-2, technologies employed, and future perspectives

Castro

Costa

2021

J Polym Res

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“…In the past, (3-chloro-2-hydroxypropyl)trimethylammonium chloride (CT-1), as one of the common quaternary ammonium compounds, has been investigated for constructing antimicrobial coatings because of the high cationic charge density in their structures. , However, it is rarely reported that CT-1 was applied in the field of photocatalysis as a modifier for regulating surface charge. The quaternary ammonium group can greatly attract the anionic groups via electrostatic attraction to improve the adsorption capacity of a quaternization substrate for anionic pollutants.…”

Section: Introductionmentioning

confidence: 99%

Regulating Alkyl Chain Length on Quaternization TiO₂ for Boosting Photocatalytic Performance: Synergism of Promoting Photogenerated Charge Separation and Improving Reactant Adsorption

Xie

Wang

Zhu

et al. 2022

ACS Appl. Mater. Interfaces

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To explore the effect of surface charge properties of a photocatalyst on photocatalytic activity, quaternization TiO2 particles with different alkyl chain lengths (CT-X/P25) are first synthesized to boost the photocatalytic activity. The effect of a quaternary ammonium group with different alkyl chain lengths on the photocatalytic activity of CT-X/P25 is investigated. Interestingly, the introduction of a quaternary ammonium group on CT-X/P25 not only contributes to improving the photodegradation efficiency of anionic dyes due to enhancing of adsorption capacity through electrostatic attraction, but also it can improve the photodegradation efficiency of cationic dyes. Therefore, there seems to be another factor affecting the photocatalytic activity. The results of photoelectric characterization show that the photogenerated charge separation of CT-X/P25 is greatly enhanced, which is beneficial to improve the photocatalytic activity. Simultaneously, the results show that the difference in the photocatalytic activity of CT-X/P25 is mainly related to the charge intensity of -N+(CH3)2- in the quaternary amine salt. According to X-ray photoelectron spectroscopy, the charge intensity of -N+(CH3)2- in CT-X/P25 gradually increases with the increase in alkyl chain lengths, which is conducive to promoting photogenerated charge separation and improving the adsorption for anionic dyes. The photocatalytic activity has been further enhanced due to the enhancement of this synergy. In summary, the quaternary ammonium salt-modified CT-X/P25 shows an excellent synergistic effect on the process of photodegradation of anionic dyes: promoting photogenerated charge separation and adsorption.

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“…analisaram as atividades anti-Staphylococcus aureus e antioxidantes de substâncias ativas presentes no extrato de acetato de etila das folhas de A. colubrina.Para o descritor "Angico Gum/Goma do Angico" foram encontrados apenas 5 artigos, sendo 1 publicação em 2017, 3 publicações 2020 e 1 publicação em 2021. Dentre os trabalhos encontrados, produziram derivados quaternizados da goma do angico e avaliaram o seu efeito anti-estafilocócico e sua toxicidades, constatando que os derivados que apresentam maior grau de substituição, possuem atividade antibacteriana mais efetiva Ribeiro et al, (2020). investigaram a atividade antifúngica e citotoxicidade, demonstrando que o polímero quaternizado de AG é um biomaterial bastante promissor para aplicações biotecnológicas Paula et al, (2017),.…”

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Prospecção cientifica e tecnológica da goma do cajueiro e goma do angico com ênfase em sistemas de liberação controlada de drogas

Santos¹,

Lima²,

Pires³

et al. 2022

RSD

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As limitações como instabilidade de bioativos em determinado meio ou processo, efeitos toxicológicos, dificuldades em solubilidade e permeabilidade, meia-vida curta, alta dosagem, bem como ação não especifica, levam a complicações no tratamento de diversas patologias. Desse modo, busca-se sistemas no qual a concentração terapêutica necessária do fármaco seja atingida de forma eficiente no local de ação, permanecendo-se constate durante o tempo de tratamento, diminuindo assim a quantidade de doses e efeitos colaterais. À vista disso, sistemas de liberação de bioativos a base de polímeros pode representar uma estratégia viável e promissora. Assim, este artigo objetivou identificar os principais estudos e aplicações tecnológicas desenvolvidas, dando ênfase a entrega controlada de drogas, em sites de publicações e depósitos de artigos, bem como patentes nacionais e internacionais. As seguintes palavras-chave: “Anadenanthera colubrina var. cebil (Griseb.) Altschul, “Anacardium occidentale”, “goma do angico/angico gum”, “goma do cajueiro/cashew gum” e “drug delivery” foram combinadas utilizando o operador booleano AND. Os artigos que envolvem as gomas do angico e cajueiro demonstram um extenso domínio de atividades biológicas, comprovando seu grande potencial para aplicações biotecnológicas. A prospecção tecnológica evidenciou que há um pequeno número de patentes depositadas se comparada com a publicação de artigos. Eenvolvendo os descritores “Anacardium occidentale” foram consedida um total de 98 patentes para a base mundial, e para o descritor “goma do cajueiro” um total de 36 patentes, sendo que não foram encontradas nenhuma patente para os descritores “Anadenanthera colubrina var. cebil (Griseb.) Altschul”, “goma do angico”, e as combinações “angico gum AND drug delivery” “cashew gum AND drug delivery”.

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Structural characterization, antifungal and cytotoxic profiles of quaternized heteropolysaccharide from Anadenanthera colubrina

Cited by 18 publications

References 63 publications

Polymeric surfaces with biocidal action: challenges imposed by the SARS-CoV-2, technologies employed, and future perspectives

Polymeric surfaces with biocidal action: challenges imposed by the SARS-CoV-2, technologies employed, and future perspectives

Regulating Alkyl Chain Length on Quaternization TiO₂ for Boosting Photocatalytic Performance: Synergism of Promoting Photogenerated Charge Separation and Improving Reactant Adsorption

Prospecção cientifica e tecnológica da goma do cajueiro e goma do angico com ênfase em sistemas de liberação controlada de drogas

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Structural characterization, antifungal and cytotoxic profiles of quaternized heteropolysaccharide from Anadenanthera colubrina

Cited by 18 publications

References 63 publications

Polymeric surfaces with biocidal action: challenges imposed by the SARS-CoV-2, technologies employed, and future perspectives

Polymeric surfaces with biocidal action: challenges imposed by the SARS-CoV-2, technologies employed, and future perspectives

Regulating Alkyl Chain Length on Quaternization TiO2 for Boosting Photocatalytic Performance: Synergism of Promoting Photogenerated Charge Separation and Improving Reactant Adsorption

Prospecção cientifica e tecnológica da goma do cajueiro e goma do angico com ênfase em sistemas de liberação controlada de drogas

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Product

Resources

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Regulating Alkyl Chain Length on Quaternization TiO₂ for Boosting Photocatalytic Performance: Synergism of Promoting Photogenerated Charge Separation and Improving Reactant Adsorption