Structural characterization of calcium glycinate, magnesium glycinate and zinc glycinate

Abstract

Metal glycinate chelates are formed by glycine and metal compounds through chemical reactions. Calcium glycinate, magnesium glycinate and zinc glycinate are kinds of new-type and ideal nutrient supplements, which have satisfactory physico-chemical properties and bioactivities. They are important for prophylaxis and treat metal de¯ciency. The structural characterization shows that the metal ion is bonded to the amino and carboxyl group to form two¯ve-membered rings. This paper mainly studies the structure characterization of the metal chelated glycinates by their solubility, infrared spectrum, thermal analysis, mass spectrometry, polycrystal di®rac-tion, the metal contents and glycine contents of calcium glycinate, magnesium glycinate and zinc glycinate.

Targeted Codelivery of Prodigiosin and Simvastatin Using Smart BioMOF: Functionalization by Recombinant Anti-VEGFR1 scFv

“…In this study, we synthesized a non-toxic Ca-based BioMOF, which is named Ca-Gly. As shown in Figure 1 , Ca 2+ coordinates with the carboxyl (-COOH) and amino (-NH 2 ) groups of glycine ( Yin et al, 2017 ). Water molecules are also present in the crystal lattice and the Ca 2+ ions are associated with the oxygen of water.…”

Synthesis and Chemical and Biological Evaluation of a Glycine Tripeptide Chelate of Magnesium

“…The uncomplexed HG3 exhibited three singlets at 4.044, 3.914 and 3.786 ppm, whereas the MgG3 complex showed an observable shift for each of the proton peaks at 3.967, 3.747, 3.4077, respectively (Figure 2.1.2. Structural Characterization of MgG 3 via 1 H-NMR and 2D 1 H/ 13 C HSQC/HMBC NMR It is well established, in the literature, that divalent metal amino acid chelates exhibit ligand chelation predominantly through the carboxylic acid hydroxyl group and the nearest amine (e.g., glycine and glutamate) [43,44], but entropically-favored tri-and tetradentate complexes will occur primarily (e.g., aspartate) [44]. Ligand chelation to magnesium typically results in an observable shift of the proton signals adjacent to the Lewis bases of the free ligand that participate in coordination, as a consequence of the electropositive character of the metal [47][48][49].…”

“…The aqueous solubilities (g/100 mL) at room temperature, acid/base chemistry, molecular weight, and percent magnesium composition of common magnesium supplements. The naturally occurring glycine peptide trimer, triglycine (IUPAC: 2-[[2-[(2aminoacetyl) amino]acetyl]amino]acetic acid-HG 3 : not to be confused with trisglycine, three individual glycine monomers bound to a metal ion) [41], isolated from the Ackee (Blighia sapida) seed in 1968 by Fowden et al [42], was chosen as the magnesium chelate ligand by virtue of several significant characteristics, namely, multiple Lewis base moieties that give rise to entropically favored binding (bidentate, tridentate, or tetradentate), extensive hydrogen bond donors/acceptors-when both free and complexed-offering inherent stability [43], well-understood coordination chemistry through the carboxylic acid moiety [44], weakly acidic character [37]; and evidence indicating a higher achievable plasma concentration than both its monomer and dimer progenitors [45].…”

Effect of Vacancy Defects and Hydroxyl on the Adsorption of Glycine on Mg(0001): A First-Principles Study

“…A single carbon molecule is linked to an amino and a carboxyl group, making it the simplest amino acid among all amino acids [23,24]. The investigation of the surface structure and properties of Gly and biomaterials is not only a significant subject in the fields of life sciences and medicine but also a crucial scientific matter in the domains of chemistry, materials science, and the pharmaceutical industry [25][26][27][28][29][30]. Kumar et al optimized the adsorption geometries of Gly and suggested covalent bonding between N and O atoms of the molecules and the surface Cu-atoms [24].…”