Structural characterization of chitosan and oxidized carboxymethyl cellulose based freeze-dried films

Abstract

The conversion of dihydroxyl groups to dialdehyde by periodate oxidation is a useful method widely used in derivatization of cellulose. Periodate oxidation is a highly specific reaction to convert 1,2-dihydroxyl groups to paired aldehyde groups without significant side reactions. This reaction cleaves the C2-C3 bond; the resulting compound is the dialdehyde cellulose (DAC). These aldehyde groups of carboxymethyl cellulose interact with amino group of chitosan and their interaction results in the formation Schiff's base with enhanced properties of both the polymers, i.e., of chitosan and carboxymethyl cellulose. Interaction of chitosan and oxidized carboxymethyl cellulose (OCMC) has been carried out with three combinations, i.e., 5, 10, and 15 wt% OCMC with rest of chitosan in 2% lactic acid solution. This new compound is covalently crosslinked which has been analyzed by various techniques like FTIR, TGA, XRD, and SEM.

Preparation and Characterization of Acid Resistant Double Cross-Linked Hydrogel for Potential Biomedical Applications

“…The second stage of weight loss ranged from 100 to 200 °C, which was owing to the loss of CO 2 from polysaccharide. This result also revealed the formation of aldehyde groups in polysaccharide . Due to the removal of a small portion of the incomplete reaction of furan, DN hydrogel sample showed a slight weight loss in the initial stage.…”

“…This result also revealed the formation of aldehyde groups in polysaccharide. 48 Due to the removal of a small portion of the incomplete reaction of furan, DN hydrogel sample showed a slight weight loss in the initial stage. In addition, the thermal stability of the sample was usually known by examining the maximum degradation temperature (T max ).…”

“…Finally, 1 mL of DMEM was added into each well, and the cells (1 × 10 5 cells/well) were cultured at 37 °C with 5% CO 2 . The medium was changed every 12 h. After a period of incubation (12,24,48, or 72 h), the harvested cells were stained using a fluorescence double-staining kit QIA76 (EMD Millipore, United States), and the cell viability was measured by MTT assay. Finally, a fluorescent microcopy was utilized to observe the morphology, distribution, and viability of the cells.…”

Study on microcrystalline cellulose/chitosan blend foam gel material

“…Chemical cross-linking refers to a permanent connection formed by covalent bonds between polymers, commonly improving the mechanical properties of polymers. Overall, conventional water-absorbing materials are synthesized in the presence of cross-linking agents (e.g., acrylic acid, acrylamide, glutaraldehyde, polyethylene glycol, potassium persulfate and tripolyphosphoric acid) [12][13][14][15]. Via the chemical cross-linking, permanent connection can be developed by covalent between polymers, generally improving the mechanical properties of materials.…”

Physico-Chemical Studies of Chitosan Derivatives and Optimization of Reaction Conditions using RSM Design

“…in many fields such as tissue engineering, biomedicine, waste water treatment, functional membrane and flocculation. Chitosan also finds its application in novel drug delivery as mucoadhesive, peptide and gene delivery, and oral enhancer have also been reported [5,6]. It is also used in cosmetics, agriculture and biomaterials and in particular, excellent activity as a wound healing accelerator combined with antibacterial capability and good tissue compatibility of chitosan made it become an excellent wound dressing materials.…”