Structural characterization of polysaccharides from Zizyphus jujuba and evaluation of antioxidant activity

Chang, S.C.; Hsu, Bo‐Yang; Chen, B.H.

doi:10.1016/j.ijbiomac.2010.06.010

Cited by 154 publications

(88 citation statements)

References 30 publications

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“…The herb exerts inhibitory activity against histamine release and AChE and cyclooxygenase I and II inhibitory activity. Flavonoids present exert antioxidant properties [103] Cis-9-octadecenamide (oleamide), a compound extracted from jujube is reported to have high effect on the activation of acetylcholine transferase (34.1%) in the in vitro CONCLUSION which leads to the increase in acetylcholine level and improves mild to moderate cognitive functions, learning and memory, motor coordination and behavioral disorders [104].…”

Section: Zizyphus Jujubementioning

confidence: 99%

Herbal Medicines as Neuroprotective Agent: A Mechanistic Approach

Roy

Awasthi

2017

Int J Pharm Pharm Sci

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Neurodegeneration refers to a condition of neuronal death occurring as a result of progressive disease of long-term and is becoming a major health problem in the 21st century. Neurons degenerated are not replaced resulting in a cognitive loss, many neurodegenerative disorders, such as schizophrenia, depression, Alzheimer's disease (AD), dementia, cerebrovascular impairment, seizure disorders, head injury, parkinsonism. The common pathology of neurodegeneration includes deposition of misfolded proteins such as amyloid-β (Aβ) in Alzheimer's disease, α-synuclein in Parkinson's disease (PD), transactive response DNA-binding protein 43 (TDP-43) in dementia. Neuroprotection refers to the strategies and possible mechanisms that are able to protect the central nervous system (CNS) against neuronal injury and neurodegenerative disorders. The past decade has witnessed an intense interest in herbal plants having long-term health-promoting or medicinal qualities. Comprehensive research and discovery have demonstrated that natural products, medicinal herbs, plant extracts, and their metabolites, have great potential as the neuroprotective agent. Although the precise mechanisms of action of herbal drugs have yet to be determined, some of them have been shown to prevent formation of betaamyloid plaques, promote nerve growth, some inhibit acetylcholinesterase (AChE) enzyme and malondialdehyde (MDA) formation in brain while other exhibits antioxidant activity by increasing the level of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx). Thus the herbal plants can be a valuable source of the drug against neurodegenerative disorders which will require high-throughput screening. This review will highlight the role of herbal plants and their phytoconstituents against neurodegenerative diseases and other related disorders, focusing on their mechanism of action and therapeutic potential.

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Section: Zizyphus Jujubementioning

confidence: 99%

Herbal Medicines as Neuroprotective Agent: A Mechanistic Approach

Roy

Awasthi

2017

Int J Pharm Pharm Sci

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“…By summarizing all the results in the literature reports, it can be concluded that the extraction of jujube polysaccharides is usually conducted by 80-95 % ethanol with refluxing for removal of lipids, proteins, monosaccharides, or pigments (Zhao et al 2006a;Wang et al 2012a;Li et al 2013), followed by hot water (80-100 C) extraction, precipitation with 75-95 % ethanol, centrifugation or filtration, and freeze-drying (Zhao et al 2006a;Chang et al 2010;Wang et al 2012a;Li et al 2013). In addition, some more new methods, such as application of enzyme, sonication, and flocculation for polysaccharide extraction, have been developed, which are described below.…”

Section: Extraction Of Jujube Polysaccharidesmentioning

confidence: 99%

“…Thus, the extraction efficiency of polysaccharides can be affected by variety and volume of solvent as well as extraction time and temperature (Li et al 2007b). In a study dealing with the extraction of jujube polysaccharides in Taiwan, Chang et al (2010) used 75 mL of hot water (90 C) for extraction for 6 h, followed by precipitate removal by centrifugation, collection of supernatant for concentration, addition of 95 % ethanol for polysaccharide precipitation for 5 h at 4 C, protein hydrolysis by proteinase, dialysis, and column chromatography for fractionation into neutral and acidic polysaccharides. Several similar methods were also used by some other authors ).…”

Section: Hot Water Extraction and Ethanol Precipitationmentioning

confidence: 99%

Functional components in Zizyphus with emphasis on polysaccharides

Kao

Chen

2014

Polysaccharides

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Zizyphus jujuba (Chinese jujube), mainly distributed in the subtropical regions of Asia, has been cultivated for over 4,000 years and used as food, food additive, flavor, as well as traditional Chinese herb, as it possesses analeptic, palliative, and antibechic functions. The fruit of jujube is quite popular due to high nutritional value and presence of many functional components, in which polysaccharide is the most important one. Polysaccharides, being essential constituents of all living organisms, are naturally occurring polymers of aldoses and ketoses linked together through glycosidic linkages. In recent years, polysaccharides of plant origin have emerged as a vital class of bioactive nature products; however, there is a lack of information regarding analysis and biological activity of jujube polysaccharides. Moreover, the composition of polysaccharides in jujube may vary with different species, growth environment, cultivar variety, and extraction and separation methods, which in turn may affect the overall biological activity. The objective of this manuscript is to review the current status associated with jujube polysaccharide, including nutritional and functional components; methods of extraction, purification, separation, identification, and quantitation; as well as biological activity.

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“…Moreover, it has been reported that the antibacterial activity of polysaccharide might depend on its monosaccharide composition, molecular weight and structure of the polymeric backbone [21][22][23]. The relatively higher molecular mass seemed to increase the antibacterial activities [24]. Our data showed that the molecular weight distribution of POL3 was 108kd and higher than that of POL1b and POL2b (shown in Table 1), moreover, the antibacterial activity of POL3 was stronger than other two fractions and the antibacterial effect on the microorganisms was the most effective.…”

Section: Discussionmentioning

confidence: 99%

Extraction, purification and antibacterial activity of polysaccharides from Purslane

Gu¹,

Shu²

2017

Proceedings of the 2017 6th International Conference on Energy, Environment and Sustainable Development (ICEESD 2017)

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Abstract. In this study, the polysaccharides from Purslane were extracted by ultrasonic method and its content was measured by the phenol-sulfuric acid method using glucose as the standard. The crude polysaccharides were collected and purified by DEAE-Cellulose anion-exchange and Sephadex gel-permeation chromatography. Three fractions were obtained and named POL1, POL2 and POL3, respectively. The molecular weights of these three fractions were measured by Sephadex using dextran standard curve. Escherichia coli, Acetic acid bacteria, Saccharomycetes and Aspergillus Niger were used to study the antibacterial activity of the polysaccharides. The results showed that molecular weights of POL1, POL2 and POL3 were 18Kd, 55kd and 108kd, respectively. The polysaccharides had inhibitory effect on microorganisms, and the inhibited order of microorganisms was: Saccharomycetes>Acetic acid bacteria>Aspergillus Niger>Escherichia coli. In addition, the order of antibacterial activities of these three fractions on microorganisms was: POL3>POL2b>POL1b. It could be concluded that three fractions were obtained by purification. These three fractions had inhibitory effect on Saccharomycetes, Acetic acid bacteria, Aspergillus Niger and Escherichia coli. The antibacterial activity of polysaccharides from Purslane against Saccharomycetes was the strongest, while the weakest against Escherichia coli. In addition, POL3 was found to be the most effective against the tested microorganisms among the three fractions.

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Structural characterization of polysaccharides from Zizyphus jujuba and evaluation of antioxidant activity

Cited by 154 publications

References 30 publications

Herbal Medicines as Neuroprotective Agent: A Mechanistic Approach

Herbal Medicines as Neuroprotective Agent: A Mechanistic Approach

Functional components in Zizyphus with emphasis on polysaccharides

Extraction, purification and antibacterial activity of polysaccharides from Purslane

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