Structural characterization of sulfated galactofucan from Undaria pinnatifida and its effect on type 2 diabetic mice

Ke, Songze; Zhang, Bo; Yu, Yanlei; Wang, Sijia; Jin, Weihua; Wu, Jian; Chen, Jianwei; Zhang, Huawei; Wei, Bin; Wang, Hong

doi:10.1007/s00343-021-1307-3

Cited by 3 publications

(2 citation statements)

References 44 publications

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“…Sulfated polysaccharides derived from the brown seaweed Undaria pinnatifida (e.g., sulfated galactofucan) mitigated insulin resistance, improved glucose tolerance and dyslipidemia, and reduced hepatic steatosis and damage to pancreatic islets, liver, and kidney. Such improvements were associated with changes to the intestinal microbiota [142,145,146]. In diabetic mice, the hypoglycemic effect of polysaccharides from Laminaria japonica was observed together with increased insulin and lipid levels in serum [140,141], while an unidentified polysaccharide from the red algae Gracilaria lemaneiformis, alleviating hyperglycaemia and pancreas and kidney tissue damage, likely acts thanks to its antioxidant effects [143].…”

Section: Pre-clinical Studies On Marine Compounds For T2dm Treatmentmentioning

confidence: 99%

Marine Compounds and Age-Related Diseases: The Path from Pre-Clinical Research to Approved Drugs for the Treatment of Cardiovascular Diseases and Diabetes

Giuliani,

Bigossi,

Lai

et al. 2024

Marine Drugs

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Ageing represents a main risk factor for several pathologies. Among them, cardiovascular diseases (CVD) and type 2 diabetes mellitus (T2DM) are predominant in the elderly population and often require prolonged use of multiple drugs due to their chronic nature and the high proportion of co-morbidities. Hence, research is constantly looking for novel, effective molecules to treat CVD and T2DM with minimal side effects. Marine active compounds, holding a great diversity of chemical structures and biological properties, represent interesting therapeutic candidates to treat these age-related diseases. This review summarizes the current state of research on marine compounds for the treatment of CVD and T2DM, from pre-clinical studies to clinical investigations and approved drugs, highlighting the potential of marine compounds in the development of new therapies, together with the limitations in translating pre-clinical results into human application.

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Section: Pre-clinical Studies On Marine Compounds For T2dm Treatmentmentioning

confidence: 99%

Marine Compounds and Age-Related Diseases: The Path from Pre-Clinical Research to Approved Drugs for the Treatment of Cardiovascular Diseases and Diabetes

Giuliani,

Bigossi,

Lai

et al. 2024

Marine Drugs

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“…Lactobacillus is a widely recognized probiotic, and several species of the genus have been shown to lower and control blood glucose levels, enhance antioxidant capacity, exert anti-inflammatory effect, and prevent organ damage (52)(53)(54). Candidatus_Saccharimonas is an acid-producing bacterium that has an important role in maintaining intestinal pH (55). Ruminococcaceae UCG-005 can enhance the production of short-chain fatty acids, which in turn regulates the expression of Bax and Bcl-2 in islets, thereby alleviating islet damage (56,57).…”

Section: B Amentioning

confidence: 99%

Integrated 16S rRNA sequencing and nontargeted metabolomics analysis to reveal the mechanisms of Yu-Ye Tang on type 2 diabetes mellitus rats

Ma,

Sun,

Wang

et al. 2023

Front. Endocrinol.

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IntroductionYu–Ye Tang (YYT) is a classical formula widely used in treatment of type 2 diabetes mellitus (T2DM). However, the specific mechanism of YYT in treating T2DM is not clear.MethodsThe aim of this study was to investigate the therapeutic effect of YYT on T2DM by establishing a rat model of T2DM. The mechanism of action of YYT was also explored through investigating gut microbiota and serum metabolites.ResultsThe results indicated YYT had significant therapeutic effects on T2DM. Moreover, YYT could increase the abundance of Lactobacillus, Candidatus_Saccharimonas, UCG-005, Bacteroides and Blautia while decrease the abundance of and Allobaculum and Desulfovibrio in gut microbiota of T2DM rats. Nontargeted metabolomics analysis showed YYT treatment could regulate arachidonic acid metabolism, alanine, aspartate and glutamate metabolism, arginine and proline metabolism, glycerophospholipid metabolism, pentose and glucuronate interconversions, phenylalanine metabolism, steroid hormone biosynthesis, terpenoid backbone biosynthesis, tryptophan metabolism, and tyrosine metabolism in T2DM rats.DiscussionIn conclusion, our research showed that YYT has a wide range of therapeutic effects on T2DM rats, including antioxidative and anti-inflammatory effects. Furthermore, YYT corrected the altered gut microbiota and serum metabolites in T2DM rats. This study suggests that YYT may have a therapeutic impact on T2DM by regulating gut microbiota and modulating tryptophan and glycerophospholipid metabolism, which are potential key pathways in treating T2DM.

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Mechanisms of recalcitrant fucoidan breakdown in marine Planctomycetota

Pérez-Cruz,

Moraleda-Montoya,

Liébana

et al. 2024

Nat Commun

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Marine brown algae produce the highly recalcitrant polysaccharide fucoidan, contributing to long-term oceanic carbon storage and climate regulation. Fucoidan is degraded by specialized heterotrophic bacteria, which promote ecosystem function and global carbon turnover using largely uncharacterized mechanisms. Here, we isolate and study two Planctomycetota strains from the microbiome associated with the alga Fucus spiralis , which grow efficiently on chemically diverse fucoidans. One of the strains appears to internalize the polymer, while the other strain degrades it extracellularly. Multi-omic approaches show that fucoidan breakdown is mediated by the expression of divergent polysaccharide utilization loci, and endo-fucanases of family GH168 are strongly upregulated during fucoidan digestion. Enzymatic assays and structural biology studies reveal how GH168 endo-fucanases degrade various fucoidan cores from brown algae, assisted by auxiliary hydrolytic enzymes. Overall, our results provide insights into fucoidan processing mechanisms in macroalgal-associated bacteria.

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Structural characterization of sulfated galactofucan from Undaria pinnatifida and its effect on type 2 diabetic mice

Cited by 3 publications

References 44 publications

Marine Compounds and Age-Related Diseases: The Path from Pre-Clinical Research to Approved Drugs for the Treatment of Cardiovascular Diseases and Diabetes

Marine Compounds and Age-Related Diseases: The Path from Pre-Clinical Research to Approved Drugs for the Treatment of Cardiovascular Diseases and Diabetes

Integrated 16S rRNA sequencing and nontargeted metabolomics analysis to reveal the mechanisms of Yu-Ye Tang on type 2 diabetes mellitus rats

Mechanisms of recalcitrant fucoidan breakdown in marine Planctomycetota

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