Structural characterization of ultra-stable higher-ordered aggregates generated by novel guanine-rich DNA sequences

Biyani, Manish; Nishigaki, Koichi

doi:10.1016/j.gene.2005.05.041

Cited by 30 publications

(27 citation statements)

References 29 publications

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“…b) Bimolecular diagonally‐looped G‐quadruplex topology. c) A possible oligomeric assembly similar to the hypothetical structure of “G‐lego” as postulated by Nishigaki et al12…”

Section: Introductionmentioning

confidence: 70%

“…Later, they demonstrated that a duplex with intervening G‐rich domains in the center could fold into quadruplexes by bending the overall duplex into a “pinched” state;10 Mirkin and co‐workers clustered gold nanoparticles on the basis of numerous G‐quadruplex interactions;11 Nishigaki and co‐workers found higher‐ordered G‐quadruplex aggregate structures, which they called “G‐lego” (Figure 1c). 12 G‐wires and frayed wires are also high‐molecular‐weight quadruplex constructs with the feature of being resistant to denaturing conditions 13, 14…”

Section: Introductionmentioning

confidence: 99%

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DNA Minicircles Connected via G‐Quadruplex Interaction Modules

Gonçalves¹,

Schmidt²,

Koeppel³

et al. 2010

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G-quadruplexes are becoming reliable alternative interaction modules for the construction of DNA nanoarchitectures due to their prompt inducibility by salts. In this Full Paper, we report the design and synthesis of two different DNA minicircles equipped with G-rich appendixes that can self-hybridize into a G-quadruplex, which acts as a DNA recruiter and glue. Both minicircles, one containing a hairpin-like G-rich region and the other an open tuning-fork-like G-rich region, have the potential to form DNA G-nanoconstructs but only the tuning-fork minicircle does so. Incubation of the tuning-fork minicircle with Na(+) and Ni(2+) results in the formation of minicircle dimers, while K(+) and Sr(2+) unexpectedly induce the formation of multimers. Moreover, a catenated DNA nanoconstruct is obtained when the components of the hairpin minicircle are incubated with K(+) or Na(+) and assembled in a stepwise sequence. All nanoconstructs are visualized by atomic force microscopy.

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“…b) Bimolecular diagonally‐looped G‐quadruplex topology. c) A possible oligomeric assembly similar to the hypothetical structure of “G‐lego” as postulated by Nishigaki et al12…”

Section: Introductionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

DNA Minicircles Connected via G‐Quadruplex Interaction Modules

Gonçalves¹,

Schmidt²,

Koeppel³

et al. 2010

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“…and efficacy of ODNs. Various DNA superstructures such as Gquartets and G-wires display increased stability in vitro relative to double and single stranded DNA structures; however, there have been few studies of their stability or delivery in vivo [37,38]. DNA FW are a self-aggregating form of DNA with two distinct structural domains (Fig.…”

Section: Discussionmentioning

confidence: 99%

In vivo disposition and stability of DNA frayed wires in mice

Yanze

Macgregor

et al. 2006

International Journal of Biological Macromolecules

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“…In contrast, CCCCGG repeats did not form phase transitions, suggesting that not all xtrRNA will possess these properties. Interestingly, guanine-rich nucleic acids are less soluble than other nucleic acids and appear to be intrinsically aggregate-prone apart from protein, especially when packing into quartets or higher-order quadruplex structures [21, 89, 179]. The disruption of membrane-free organelles, which are abundant in the nucleus, is linked to disease [198, 228, 272].…”

Section: Structure Protein Interactions and Localization Of Xtrrnamentioning

confidence: 99%

RNA biology of disease-associated microsatellite repeat expansions

Rohilla

Gagnon

2017

acta neuropathol commun

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Microsatellites, or simple tandem repeat sequences, occur naturally in the human genome and have important roles in genome evolution and function. However, the expansion of microsatellites is associated with over two dozen neurological diseases. A common denominator among the majority of these disorders is the expression of expanded tandem repeat-containing RNA, referred to as xtrRNA in this review, which can mediate molecular disease pathology in multiple ways. This review focuses on the potential impact that simple tandem repeat expansions can have on the biology and metabolism of RNA that contain them and underscores important gaps in understanding. Merging the molecular biology of repeat expansion disorders with the current understanding of RNA biology, including splicing, transcription, transport, turnover and translation, will help clarify mechanisms of disease and improve therapeutic development.

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Structural characterization of ultra-stable higher-ordered aggregates generated by novel guanine-rich DNA sequences

Cited by 30 publications

References 29 publications

DNA Minicircles Connected via G‐Quadruplex Interaction Modules

DNA Minicircles Connected via G‐Quadruplex Interaction Modules

In vivo disposition and stability of DNA frayed wires in mice

RNA biology of disease-associated microsatellite repeat expansions

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