2021
DOI: 10.3390/brainsci11081041
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Structural Connectivity Alterations in Operculo-Insular Epilepsy

Abstract: Operculo-insular epilepsy (OIE) is an under-recognized condition that can mimic temporal and extratemporal epilepsies. Previous studies have revealed structural connectivity changes in the epileptic network of focal epilepsy. However, most reports use the debated streamline-count to quantify ‘connectivity strength’ and rely on standard tracking algorithms. We propose a sophisticated cutting-edge method that is robust to crossing fibers, optimizes cortical coverage, and assigns an accurate microstructure-reflec… Show more

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Cited by 9 publications
(3 citation statements)
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“…IE is rarely limited to the insula and usually involves an extensive epileptogenic network encompassing peri‐sylvian regions and/or more distant cortical area. This is supported by a recent study revealing structural abnormalities (eg, reduced cortical thickness) extending far beyond the operculo‐insular region 85,86 . However, MRgLA and RFA can only target small volumes of brain and are limited by the vector direction of the probe 46,87 .…”
Section: Discussionmentioning
confidence: 59%
See 1 more Smart Citation
“…IE is rarely limited to the insula and usually involves an extensive epileptogenic network encompassing peri‐sylvian regions and/or more distant cortical area. This is supported by a recent study revealing structural abnormalities (eg, reduced cortical thickness) extending far beyond the operculo‐insular region 85,86 . However, MRgLA and RFA can only target small volumes of brain and are limited by the vector direction of the probe 46,87 .…”
Section: Discussionmentioning
confidence: 59%
“…This is supported by a recent study revealing structural abnormalities (eg, reduced cortical thickness) extending far beyond the operculo‐insular region. 85 , 86 However, MRgLA and RFA can only target small volumes of brain and are limited by the vector direction of the probe. 46 , 87 This may result in incomplete ablation of the EZ and explain seizure recurrence or persistence.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, some scholars have used fMRI to find structural connectivity changes in insular epilepsy. 72 Due to the complexity of insular epilepsy, it is often necessary to combine EEG/SEEG, fMRI, MEG, etc., in practical applications. 54 , 73 Given continuous development in auxiliary examination technology, EEG/fMRI has always been a hot topic and frontier in insular epilepsy research.…”
Section: Discussionmentioning
confidence: 99%