Structural Connectivity Between Rostral Anterior Cingulate Cortex and Amygdala Predicts First Onset of Depressive Disorders in Adolescence

Jin, Jingwen; Delaparte, Lauren; Chen, Hung Wei; DeLorenzo, Christine; Klein, Daniel N.; Mohanty, Aprajita; Kotov, Roman

doi:10.1016/j.bpsc.2021.01.012

Cited by 5 publications

(4 citation statements)

References 53 publications

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“…However, only one study provides insight into the neurobiological mechanisms underlying the effects of dual taxation. 31 showed that EM during recall was associated with reduced activity in certain brain regions, such as less activation of the right amygdala and rostral anterior cingulate cortex (ACC), which serve as a central hub for cognitive and emotional networks [45,46]. This study suggests a neurobiological pathway -i.e., the reduced activity of the amygdala and ACC -which may help to understand how dual taxation during EMDR leads to less vivid and less emotional traumatic stimuli.…”

Section: Discussionmentioning

confidence: 79%

Can working memory account for EMDR efficacy in PTSD?

2022

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Background: Although eye movement desensitization and reprocessing (EMDR) has been shown to be effective in the treatment of PTSD for years, it remains controversial due to the lack of understanding of its mechanisms of action. We examined whether the working memory (WM) hypothesis –the competition for limited WM resources induced by the dual task attenuates the vividness and emotionality of the traumatic memory – would provide an explanation for the beneficial effect induced by bilateral stimulation. Methods: We followed the Prisma guidelines and identified 11 articles categorized in two types of designs: studies involving participants with current PTSD symptoms and participants without PTSD diagnosis. Results: Regardless of the types of studies, the results showed a reduction of vividness and emotionality in the recall of traumatic stimuli under a dual-task condition compared to a control condition, such as recall alone. However, two studies used a follow-up test to show that this effect does not seem to last long. Conclusion: Our results provide evidence for the WM hypothesis and suggest that recalling a traumatic memory while performing a secondary task would shift the individual’s attention away from the retrieval process and result in a reduction in vividness and emotionality, also associated with the reduction of symptoms.

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Section: Discussionmentioning

confidence: 79%

Can working memory account for EMDR efficacy in PTSD?

2022

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“…For example, a study from China found the functional connectivity between the Distal ACC and left DLPFC was impaired, while, it got normalized after 12-week antidepressant treatment [ 43 ]. Jin et al found aberrant structural connectivity between the rostral ACC and amygdala prospectively predates first onset of MDD [ 44 ]. Furthermore, Cheng et al found a unique orbitofrontal cortex-subgenual ACC circuit abnormality can serve as an important biomarker for identifying refractory MDD patients [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Integrated analysis of transcriptional changes in major depressive disorder: Insights from blood and anterior cingulate cortex

Zhong,

Chen,

Liu

et al. 2024

Heliyon

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“…to the amygdala, 75 is associated with the processing of emotional expressions 76 and its abnormalities have been associated with several psychiatric disorders. 77 Its exact function remains poorly understood, however, and deserves further investigation in the context of alcohol-related emotional disorders.…”

Section: Discussionmentioning

confidence: 99%

“…For future studies, it would be interesting to conduct a multishell diffusion or DTI study on the anatomical connections between the regions we have highlighted and the limbic regions, known as a hub of emotional processing. In particular, the uncinate fasciculus, a major tract connecting the rostral part of the prefrontal cortex (PFC) to the amygdala, 75 is associated with the processing of emotional expressions 76 and its abnormalities have been associated with several psychiatric disorders 77 . Its exact function remains poorly understood, however, and deserves further investigation in the context of alcohol‐related emotional disorders.…”

Section: Discussionmentioning

confidence: 99%

Links between psychopathological symptoms and cortical thickness in men with severe alcohol use disorder: A Magnetic Resonance Imaging study

Petit

Leclercq²,

Quoilin³

et al. 2023

Neuropsychopharm Rep

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BackgroundAnxiety and depression are psychopathological states frequently co‐occurring with severe alcohol use disorder (SAUD). These symptoms generally disappear with abstinence but may persist in some patients, increasing the relapse risk.MethodsThe cerebral cortex thickness of 94 male patients with SAUD was correlated with symptoms of depression and anxiety, both measured at the end (2–3 weeks) of the detoxification treatment. Cortical measures were obtained using surface‐based morphometry implemented with Freesurfer.ResultsDepressive symptoms were associated with reduced cortical thickness in the superior temporal gyrus of the right hemisphere. Anxiety level was correlated with lower cortical thickness in the rostral middle frontal region, inferior temporal region, and supramarginal, postcentral, superior temporal, and transverse temporal regions of the left hemisphere, as well as with a large cluster in the middle temporal region of the right hemisphere.ConclusionsAt the end of the detoxification stage, the intensity of depressive and anxiety symptoms is inversely associated with the cortical thickness of regions involved in emotions‐related processes, and the persistence of the symptoms could be explained by these brain deficits.

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Structural Connectivity Between Rostral Anterior Cingulate Cortex and Amygdala Predicts First Onset of Depressive Disorders in Adolescence

Cited by 5 publications

References 53 publications

Can working memory account for EMDR efficacy in PTSD?

Can working memory account for EMDR efficacy in PTSD?

Integrated analysis of transcriptional changes in major depressive disorder: Insights from blood and anterior cingulate cortex

Links between psychopathological symptoms and cortical thickness in men with severe alcohol use disorder: A Magnetic Resonance Imaging study

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