Structural Control of Poly(Methyl Methacrylate)-<i>g</i>-poly(Lactic Acid) Graft Copolymers by Atom Transfer Radical Polymerization (ATRP)

Shinoda, Hosei; Matyjaszewski, Krzysztof

doi:10.1021/ma0105791

Cited by 182 publications

(149 citation statements)

References 43 publications

Supporting

Mentioning

143

Contrasting

Unclassified

Order By: Relevance

“…This radical can fragment either to an active chain radical (1) or a new radical resulting from the leaving group of the RAFTagent. These radicals can react with the monomer to form new propagation radicals (5). The equilibrium between the dormant polymeric RAFT species (6) and (7) and the P n .…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Reversible Addition-Fragmentation Chain Transfer Polymerization on different Synthesizer Platforms

et al. 2005

View full text Add to dashboard Cite

The reproducibility for different automated synthesizers was investigated on the basis of the reversible addition-fragmentation chain transfer (RAFT) polymerization of methyl methacrylate. Besides the reproducibility within one synthesizer and the comparability between different synthesizers also the effect of different reaction volumes (up-scaling) was investigated and compared to conventional lab experiment.

show abstract

Section: Resultsmentioning

confidence: 99%

“…combs [5], stars [6], block copolymers [7] or other architectures which are not readily synthesized using other methodologies) [8,9] with very narrow polydispersity indices. NMP and ATRP are reversible termination based polymerizations, whereas RAFT polymerizations achieve their controlled character with reversible chain transfer [10].…”

Section: Introductionmentioning

confidence: 99%

Reversible Addition-Fragmentation Chain Transfer Polymerization on different Synthesizer Platforms

et al. 2005

View full text Add to dashboard Cite

show abstract

“…1 H NMR, 13 C NMR, and 31 P NMR spectra were recorded on a Bruker Avance 400 NMR spectrophotometer (Billerica, MA), with DMSO-d 6 as the solvent. The thermal stability of the samples were measured by thermogravimetric analysis using Perkin-Elmer Instruments with a heating rate of 20°C per minute under a nitrogen atmosphere from 25°C to 900°C.…”

Section: Synthesis Of Phema-g-(pla-dppe) Copolymermentioning

confidence: 99%

“…Compared with PHEMA (Supplementary Figure S1A), the 13 C NMR spectra of the PHEMA-PLA copolymer (Supplementary Figure S1B) show that the signals at about 160-175 ppm were attributed to the C=O group carbon peak of PLA. The signals at approximately 64 and 69 ppm were assigned to the -CH group carbon peak of the PLA moiety located at the terminal groups and repeat units in the chain.…”

Section: Supplementary Details On Copolymer Synthesis and Characterizmentioning

confidence: 99%

“…[5][6][7][8][9] However, the mechanical properties of PHEMA hydrogels do not fit the requirements for many structural applications. Therefore, amphiphilic polymers consisting of PHEMA and biodegradable polyesters, ie, poly(L-lactide) (PLLA), 10,11 poly(D,L-lactide), [12][13][14] poly(glycolic acid), poly(ε-caprolactone), 15,16 and polystyrene, have been synthesized. 17 These copolymers can be obtained through ring-opening polymerization, atom transfer radical polymerization, 11,18,19 A 2 B 2 PCl/acrylate miktoarm polymers, 20 or use of a protective group, eg, a trimethylsilyl moiety.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Construction of paclitaxel-loaded poly (2-hydroxyethyl methacrylate)-g-poly (lactide)- 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine copolymer nanoparticle delivery system and evaluation of its anticancer activity

Ma¹,

Wang²,

Jin³

et al. 2012

IJN

View full text Add to dashboard Cite

Background:There is an urgent need to develop drug-loaded biocompatible nanoscale packages with improved therapeutic efficacy for effective clinical treatment. To address this need, a novel poly (2-hydroxyethyl methacrylate)-poly (lactide)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine [PHEMA-g-(PLA-DPPE)] copolymer was designed and synthesized to enable these nanoparticles to be pH responsive under pathological conditions. Methods: The structural properties and thermal stability of the copolymer was measured and confirmed by Fourier transform infrare d spectroscopy, nuclear magnetic resonance, and thermogravimetric analysis. In order to evaluate its feasibility as a drug carrier, paclitaxel-loaded PHEMA-g-(PLA-DPPE) nanoparticles were prepared using the emulsion-solvent evaporation method. Results:The PHEMA-g-(PLA-DPPE) nanoparticles could be efficiently loaded with paclitaxel and controlled to release the drug gradually and effectively. In vitro release experiments demonstrated that drug release was faster at pH 5.0 than at pH 7.4. The anticancer activity of the PHEMA-g-(PLA-DPPE) nanoparticles was measured in breast cancer MCF-7 cells in vivo and in vitro. In comparison with the free drug, the paclitaxel-loaded PHEMA-g-(PLA-DPPE) nanoparticles could induce more significant tumor regression. Conclusion: This study indicates that PHEMA-g-(PLA-DPPE) nanoparticles are promising carriers for hydrophobic drugs. This system can passively target cancer tissue and release drugs in a controllable manner, as determined by the pH value of the area in which the drug accumulates.

show abstract

Copolymerization

Barner‐Kowollik¹,

Coote²,

Davis³

et al. 2004

Encyclopedia of Polymer Science and Technology

View full text Add to dashboard Cite

This article is primarily concerned with chain copolymerization. Chain copolymerization is important as it allows a wide array of functional molecules to be designed and incorporated into polymeric materials. The article starts with a general description of free‐radical copolymerization and the models that have been applied to facilitate mechanistic understanding. In recent years it has become evident that the reaction mechanism involved in free‐radical copolymerization propagation is appreciably more complicated than originally postulated in the terminal model developed back in the 1940s. For the simple prediction of composition the terminal model, although fairly crude, provides an adequate method in many instances. However, problems arise when it is used to study absolute rate coefficients (cross‐propagation rate coefficients) or when it is used to predict other quantities such as average propagation rates or sequence distribution. After consideration of copolymerization models, the article progresses to discuss the newly emerging field of controlled/living radical copolymerization, and the novel materials that can be made using these highly versatile synthetic methods. There is brief coverage of ionic chain copolymerization and cross‐linking copolymerization.

show abstract

Structural Control of Poly(Methyl Methacrylate)-g-poly(Lactic Acid) Graft Copolymers by Atom Transfer Radical Polymerization (ATRP)

Cited by 182 publications

References 43 publications

Reversible Addition-Fragmentation Chain Transfer Polymerization on different Synthesizer Platforms

Reversible Addition-Fragmentation Chain Transfer Polymerization on different Synthesizer Platforms

Construction of paclitaxel-loaded poly (2-hydroxyethyl methacrylate)-g-poly (lactide)- 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine copolymer nanoparticle delivery system and evaluation of its anticancer activity

Copolymerization

Contact Info

Product

Resources

About