Structural control of self-assembled peptide nanostructures to develop peptide vesicles for photodynamic therapy of cancer

Kwon, Soo hyun; Lee, Donghyun; Kim, Hyoseok; Jung, Youjin; Koo, Heebeom; Lim, Yong‐beom

doi:10.1016/j.mtbio.2022.100337

Cited by 9 publications

(10 citation statements)

References 38 publications

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“…[3] More specifically, they exhibit unique attributes such as hydrogen bonding potential, inherent chirality from amino acids, polymorphism [4] and conformational rigidity stemming from peptide bonds. [3] Furthermore, peptides can be derived naturally or synthetically, and examples include recombinant hormones, antimicrobial peptides, antibodies, and recombinant enzymes, [5] in addition to the possibilities for incorporating nonnatural amino acids to diversify the chemistry further. [6] Despite significant advancements in drug development, there are still many barriers for precision medicine.…”

Section: Introductionmentioning

confidence: 99%

“…About 10 % of the drugs in the pharmaceutical market are peptide or protein drugs including 485 entries for peptide drugs in DrugBank [2] and 239 entries in THPdb of FDA‐approved peptide drugs [1] . Peptide and protein drugs have significant potential in diverse applications, ranging from sensing and catalysis to therapeutics due to their biocompatibility, flexibility in design through amino acid sequence variations, and unique molecular topologies [3] . More specifically, they exhibit unique attributes such as hydrogen bonding potential, inherent chirality from amino acids, polymorphism [4] and conformational rigidity stemming from peptide bonds [3] .…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic Peptides, Proteins and their Nanostructures for Drug Delivery and Precision Medicine

Kim,

Taslakjian,

Kim

et al. 2024

ChemBioChem

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Peptide and protein nanostructures with tunable structural features, multifunctionality, biocompatibility and biomolecular recognition capacity enable development of efficient targeted drug delivery tools for precision medicine applications. In this review article, we present various techniques employed for the synthesis and self‐assembly of peptides and proteins into nanostructures. We discuss design strategies utilized to enhance their stability, drug‐loading capacity, and controlled release properties, in addition to the mechanisms by which peptide nanostructures interact with target cells, including receptor‐mediated endocytosis and cell‐penetrating capabilities. We also explore the potential of peptide and protein nanostructures for precision medicine, focusing on applications in personalized therapies and disease‐specific targeting for diagnostics and therapeutics in diseases such as cancer.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Therapeutic Peptides, Proteins and their Nanostructures for Drug Delivery and Precision Medicine

Kim,

Taslakjian,

Kim

et al. 2024

ChemBioChem

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“…23 In the last two decades, a plethora of studies on molecular self-assembly have led to a deeper understanding of the basic principles and established the relationship between the structure and function of self-assembled systems. In situ selfassembly based on peptides has been widely discussed, [24][25][26][27] but this method is not limited to peptides, as other nanomaterials such as polymers, 28 small molecule prodrugs, 29 inorganic metals, 30 and nucleic acids 31,32 can also self-assemble. In this review, we discuss the principles of self-assembly of various nanomaterials in different microenvironments in the body, their applications, and the advantages of in situ self-assembly in drug delivery and disease diagnosis and treatment.…”

Section: Introductionmentioning

confidence: 99%

In situ stimulus-responsive self-assembled nanomaterials for drug delivery and disease treatment

Yan¹,

Liu²,

Zhao³

et al. 2023

Mater. Horiz.

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“…It has been demonstrated that self-assembled peptides with nanostructures have greater stability and performance, as well as enthralling biological effects, in comparison to standard self-assembled peptides. − The main route of cellular uptake of these peptide-based nanostructures is through endocytosis, but it is severely affected by enzymatic degradation and lysosomal entrapment. , When the nanoparticle’s surface was modified with peptides, they successfully assisted the nanoparticles in intracellular escape. Dipeptides with small molecular weight (Try-Phe) can be used to synthesize dipeptide nanoparticles, which can be self-assembled through ion chelation reactions (Zinc ion chelation reactions) .…”

Section: Introductionmentioning

confidence: 99%

Advances in Peptide-Decorated Targeted Drug Delivery: Exploring Therapeutic Potential and Nanocarrier Strategies

Buddhiraju,

Yadav,

Dey

et al. 2023

ACS Appl. Bio Mater.

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Peptides are ideal biologicals for targeted drug delivery and have also been increasingly employed as theranostic tools in treating various diseases, including cancer, with minimal or no side effects. Owing to their receptor-specificity, peptidemediated drug delivery aids in targeted drug delivery with better pharmacological biodistribution. Nanostructured self-assembled peptides and peptide−drug conjugates demonstrate enhanced stability and performance and captivating biological effects in comparison with conventional peptides. Moreover, they serve as valuable tools for establishing interfaces between drug carriers and biological systems, enabling the traversal of multiple biological barriers encountered by peptide−drug conjugates on their journeys to their intended targets. Peptide-based drugs play a pivotal role in the field of medicine and hold great promise for addressing a wide range of complex diseases such as cancer and autoimmune disorders. Nanotechnology has revolutionized the fields of medicine, biomedical engineering, biotechnology, and engineering sciences over the past two decades. With the help of nanotechnology, better delivery of peptides to the target site could be achieved by exploiting the small size, increased surface area, and passive targeting ability of the nanocarrier. Furthermore, nanocarriers also ensure safe delivery of the peptide moieties to the target site, protecting them from degradation. Nanobased peptide delivery systems would be of significant importance in the near future for the successful targeted and efficient delivery of peptides. This review focuses on peptide−drug conjugates and nanoparticle-mediated self-assembled peptide delivery systems in cancer therapeutics.

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Structural control of self-assembled peptide nanostructures to develop peptide vesicles for photodynamic therapy of cancer

Cited by 9 publications

References 38 publications

Therapeutic Peptides, Proteins and their Nanostructures for Drug Delivery and Precision Medicine

Therapeutic Peptides, Proteins and their Nanostructures for Drug Delivery and Precision Medicine

In situ stimulus-responsive self-assembled nanomaterials for drug delivery and disease treatment

Advances in Peptide-Decorated Targeted Drug Delivery: Exploring Therapeutic Potential and Nanocarrier Strategies

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