Structural correlates of electrical remodeling in ventricular hypertrophy

Long‐term blockade of L/N‐type Ca2+channels by cilnidipine ameliorates repolarization abnormality of the canine hypertrophied heart

“…This is the first study to show a recovery from electrical remodelling in the volume‐overloaded hypertrophied heart (Peschar et al. , 2003; Reddy et al. , 2003; Schoenmakers et al.…”

“…A previous report has suggested that regression of structural and electrical remodelling should be considered clinically as an independent process for the prevention of the onset of lethal arrhythmias in the future (Peschar et al. , 2003), because regression of ventricular hypertrophy did not necessarily improve the electrical remodelling in the canine model of chronic atrioventricular block (Reddy et al. , 2003).…”

“…A previous report has suggested that regression of structural and electrical remodelling should be considered clinically as an independent process for the prevention of the onset of lethal arrhythmias in the future (Peschar et al, 2003), because regression of ventricular hypertrophy did not necessarily improve the electrical remodelling in the canine model of chronic atrioventricular block (Reddy et al, 2003). Although the electrical remodelling caused by volume overload is thought to be an irreversible phenomenon (Peschar et al, 2003), the present study successfully demonstrated that cilnidipine can shorten the ventricular repolarization period of the chronic atrioventricular block in this canine model.…”

“…Modulation of the pathophysiology of the electrical remodelling may become a new pharmacological strategy, an upstream therapy, to reduce the risk of lethal arrhythmias. However, the electrical remodelling in the hypertrophied heart caused by volume overload has been found to be refractory to pharmacological therapy with an angiotensin AT1 receptor blocker and to cardiac pacing, a non-pharmacological therapy (Peschar et al, 2003;Reddy et al, 2003;Schoenmakers et al, 2003).…”

Evaluation of left ventricular hypertrophy in patients requiring permanent pacing

“…Previous studies have shown that electrical remodelling associated with hypertrophy causes an increased frequency of ventricular ectopy and aberrant conduction [Reddy et al 2003;Xiao et al 1994]. More recent evidence suggests that severe hypertrophy is characterized by delayed conduction, resulting from an increase in junctional resistance [Bacharova et al 2009].…”