Structural correlates of emotional response to electrical stimulation of the amygdala in subjects with PTSD

Avecillas-Chasín, Josué M; Justo, Monica; Levinson, S. Rock; Koek, Ralph J.; Krahl, Scott E.; Chen, James Wy.; Lee, Seung Jin; Langevin, Jean-Philippe; Bari, Ausaf

doi:10.1016/j.brs.2019.12.004

Cited by 7 publications

(8 citation statements)

References 10 publications

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“…Clinical interventions have demonstrated the role of the amygdala in several behavioral and psychiatric disorders 5 , 8 , 45 , 63 – 65 . The behavioral effects of these interventions have shed light on the understanding of the amygdala network and how modulation of specific subregions within this nuclear complex can produce a broad range of positive and negative clinical effects 63 , 64 , 66 – 69 . The resolution of the conventional imaging studies, however, does not allow us to recognize the specific points associated with different behavioral outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…Clinical interventions have demonstrated the role of the amygdala in several behavioral and psychiatric disorders 5,8,45,[63][64][65] . The behavioral effects of these interventions have shed light on the understanding of the amygdala network and how modulation of specific subregions within this nuclear complex can produce a broad range of positive and negative clinical effects 63,64,[66][67][68][69] . The resolution of the conventional imaging studies, however, does not allow us to recognize the specific points associated with different behavioral outcomes.…”

Section: Discussionmentioning

confidence: 99%

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Connectivity-based parcellation of the amygdala and identification of its main white matter connections

Avecillas-Chasín

Levinson

Kuhn

et al. 2023

Sci Rep

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The amygdala plays a role in emotion, learning, and memory and has been implicated in behavioral disorders. Better understanding of the amygdala circuitry is crucial to develop new therapies for these disorders. We used data from 200 healthy-subjects from the human connectome project. Using probabilistic tractography, we created population statistical maps of amygdala connectivity to brain regions involved in limbic, associative, memory, and reward circuits. Based on the amygdala connectivity with these regions, we applied k-means clustering to parcellate the amygdala into three clusters. The resultant clusters were averaged across all subjects and the main white-matter pathways of the amygdala from each averaged cluster were generated. Amygdala parcellation into three clusters showed a medial-to-lateral pattern. The medial cluster corresponded with the centromedial and cortical nuclei, the basal cluster with the basal nuclei and the lateral cluster with the lateral nuclei. The connectivity analysis revealed different white-matter pathways consistent with the anatomy of the amygdala circuit. This in vivo connectivity-based parcellation of the amygdala delineates three clusters of the amygdala in a mediolateral pattern based on its connectivity with brain areas involved in cognition, memory, emotion, and reward. The human amygdala circuit presented in this work provides the first step for personalized amygdala circuit mapping for patients with behavioral disorders.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Connectivity-based parcellation of the amygdala and identification of its main white matter connections

Avecillas-Chasín

Levinson

Kuhn

et al. 2023

Sci Rep

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“…Our findings may help to inform strategies and identify potential targets of neuromodulatory therapy. Our group previously reported an association between stimulation of the BN and hedonic emotions (e.g., happiness and euphoria) in PTSD patients (Avecillas-Chasin et al, 2020 ). This effect may be important to note with regards to future neuromodulatory therapies for addiction, especially given previous studies describing the increase in NAc dopamine release and relapse in drug-seeking behavior with non-specific BLA stimulation (Blaha et al, 1997 ; Floresco et al, 1998 ; Hayes et al, 2003 ; Li et al, 2018 ).…”

Section: Discussionmentioning

confidence: 82%

Amygdala Structural Connectivity Is Associated With Impulsive Choice and Difficulty Quitting Smoking

Bari

Sparks

Levinson

et al. 2020

Front. Behav. Neurosci.

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Introduction: The amygdala is known to play a role in mediating emotion and possibly addiction. We used probabilistic tractography (PT) to evaluate whether structural connectivity of the amygdala to the brain reward network is associated with impulsive choice and tobacco smoking. Methods: Diffusion and structural MRI scans were obtained from 197 healthy subjects (45 with a history of tobacco smoking) randomly sampled from the Human Connectome database. PT was performed to assess amygdala connectivity with several brain regions. Seed masks were generated, and statistical maps of amygdala connectivity were derived. Connectivity results were correlated with a subject performance both on a delayed discounting task and whether they met specified criteria for difficulty quitting smoking. Results: Amygdala connectivity was spatially segregated, with the strongest connectivity to the hippocampus, orbitofrontal cortex (OFC), and brainstem. Connectivity with the hippocampus was associated with preference for larger delayed rewards, whereas connectivity with the OFC, rostral anterior cingulate cortex (rACC), and insula were associated with preference for smaller immediate rewards. Greater nicotine dependence with difficulty quitting was associated with less hippocampal and greater brainstem connectivity. Scores on the Fagerstrom Test for Nicotine Dependence (FTND) correlated with rACC connectivity. Discussion: These findings highlight the importance of the amygdala-hippocampal-ACC network in the valuation of future rewards and substance dependence. These results will help to identify potential targets for neuromodulatory therapies for addiction and related disorders.

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“…The inputs to and outputs from the amygdala include ventral amygdalofugal pathway, stria terminalis, basal forebrain, temporal lobe structures, olfactory stria, thalamus, hypothalamus, striatum, and brain stem (Whalen and Phelps, 2009). To investigate the neural circuits involved in the various stimulation conditions, we have done an analysis of the volume of tissue activated (Avecillas-Chasin et al, 2019). It showed that the positive effects arise from stimulating the basal nucleus and associate with the ventral amydalofugal pathway.…”

Section: The Amygdala and Emotionsmentioning

confidence: 99%

Acute Effects and the Dreamy State Evoked by Deep Brain Electrical Stimulation of the Amygdala: Associations of the Amygdala in Human Dreaming, Consciousness, Emotions, and Creativity

Lai

Langevin

Koek

et al. 2020

Front. Hum. Neurosci.

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Acute DBS of Amygdala negative responses and 2-4 V stimulation showed inversely coupled positive and negative responses of the amygdala in either hemisphere which may imply hemispheric dominance of emotional valences without relation to handedness. Due to the unique and complex responses dependent on location and strength of stimulation, we advise that all patients receiving DBS of the amygdala undergo acute stimulation mapping in a monitored setting before selecting therapeutic parameters for chronic stimulation.

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Structural correlates of emotional response to electrical stimulation of the amygdala in subjects with PTSD

Cited by 7 publications

References 10 publications

Connectivity-based parcellation of the amygdala and identification of its main white matter connections

Connectivity-based parcellation of the amygdala and identification of its main white matter connections

Amygdala Structural Connectivity Is Associated With Impulsive Choice and Difficulty Quitting Smoking

Acute Effects and the Dreamy State Evoked by Deep Brain Electrical Stimulation of the Amygdala: Associations of the Amygdala in Human Dreaming, Consciousness, Emotions, and Creativity

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