Structural covariance of amygdala subregions is associated with trait aggression and endogenous testosterone in healthy individuals

Göttlich, Martin; Buades-Rotger, Macià; Wiechert, Juliana; Beyer, Frederike; Krämer, Ulrike M.

doi:10.1016/j.neuropsychologia.2021.108113

Cited by 6 publications

(2 citation statements)

References 84 publications

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“…Secondly, men and women have distinct hormone levels and thought processes, which may potentially have an effect on the occurrence of violent conduct. According to certain research, testosterone plays a complex role in social interaction in humans, and also promotes violence [ 74 ]. By changing the link between brain activity and the “threshold” for aggression, sex hormones promote persistent aggressive behavior [ 75 ].…”

Section: Discussionmentioning

confidence: 99%

The Predictive Value of Monocyte/High-Density Lipoprotein Ratio (MHR) and Positive Symptom Scores for Aggression in Patients with Schizophrenia

Cheng

Zhang

et al. 2023

Medicina

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Background and Objectives: Schizophrenia with aggression often has an inflammatory abnormality. The monocyte/high-density lipoprotein ratio (MHR), neutrophil/high-density lipoprotein ratio (NHR), platelet/high-density lipoprotein ratio (PHR) and lymphocyte/high-density lipoprotein ratio (LHR) have lately been examined as novel markers for the inflammatory response. The objective of this study was to assess the relationship between these new inflammatory biomarkers and aggression in schizophrenia patients. Materials and Methods: We enrolled 214 schizophrenia inpatients in our cross-sectional analysis. They were divided into the aggressive group (n = 94) and the non-aggressive group (n = 120) according to the Modified Overt Aggression Scale (MOAS). The severity of schizophrenia was assessed using the Positive and Negative Syndrome Scale (PANSS). The numbers of platelets (PLT), neutrophils (NEU), lymphocytes (LYM), monocytes (MON) and the high-density lipoprotein (HDL) content from subjects were recorded. The NHR, PHR, MHR and LHR were calculated. We analyzed the differences between those indexes in these two groups, and further searched for the correlation between inflammatory markers and aggression. Results: Patients with aggression had higher positive symptom scores (p = 0.002). The values of PLT, MON, MHR and PHR in the aggressive group were considerably higher (p < 0.05). The NHR (r = 0.289, p < 0.01), LHR (r = 0.213, p < 0.05) and MHR (r = 0.238, p < 0.05) values of aggressive schizophrenia patients were positively correlated with the total weighted scores of the MOAS. A higher MHR (β = 1.529, OR = 4.616, p = 0.026) and positive symptom scores (β = 0.071, OR = 1.047, p = 0.007) were significant predictors of aggression in schizophrenia patients. Conclusions: The MHR and the positive symptom scores may be predictors of aggressive behavior in schizophrenia patients. The MHR, a cheap and simple test, may be useful as a clinical tool for risk stratification, and it may direct doctors’ prevention and treatment plans in the course of ordinary clinical care.

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Section: Discussionmentioning

confidence: 99%

The Predictive Value of Monocyte/High-Density Lipoprotein Ratio (MHR) and Positive Symptom Scores for Aggression in Patients with Schizophrenia

Cheng

Zhang

et al. 2023

Medicina

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“…Aggressive behavior in response to provocations is associated with neural reactivity in the amygdala, dorsal striatum, insula, and prefrontal areas (Skibsted et al, 2017), and individual differences in their reactivity may underlie individual differences in aggression. Aggressive individuals show enhanced structural covariance between amygdala and insula, but lower covariance between amygdala and dorsolateral prefrontal cortex (Göttlich et al, 2022). In light of the data discussed above on the involvement of vMPFC in the processing of self‐relevant information, it is interesting to note that this region appears to play a special role in the regulation of social‐reactive aggression (Lotze et al, 2007), and its transcranial direct current stimulation (tDCS) decreases outbursts of anger during interpersonal provocations, an effect more pronounced in participants with a greater tendency to use suppression as an emotion‐regulation strategy (Gilam et al, 2018; Gilam, 2021).…”

Section: Introductionmentioning

confidence: 99%

Representational similarity analysis of self‐ versus other‐processing: Effect of trait aggressiveness

Knyazev,

Savostyanov,

Bocharov

et al. 2024

Aggressive Behavior

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In this study, using the self/other adjective judgment task, we aimed to explore how people perceive themselves in comparison to various other people, including friends, strangers, and those they dislike. Next, using representational similarity analysis, we sought to elucidate how these perceptual similarities and differences are represented in brain activity and how aggressiveness is related to these representations. Behavioral ratings show that, on average, people tend to consider themselves more like their friends than neutral strangers, and least like people they dislike. This pattern of similarity is positively correlated with neural representation in social and cognitive circuits of the brain and negatively correlated with neural representation in emotional centers that may represent emotional arousal associated with various social objects. Aggressiveness seems to predispose a person to a pattern of behavior that is the opposite of the average pattern, that is, a tendency to think of oneself as less like one's friends and more like one's enemies. This corresponds to an increase in the similarity of the behavioral representation with the representation in the emotional centers and a decrease in its similarity with the representation in the social and cognitive centers. This can be seen as evidence that in individuals prone to aggression, behavior in the social environment may depend to a greater extent on the representation of social objects in the emotional rather than social and cognitive brain circuits.

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Occurrence, analysis and removal of pesticides, hormones, pharmaceuticals, and other contaminants in soil and water streams for the past two decades: a review

Kanan

Moyet²,

Obeideen³

et al. 2022

Res Chem Intermed

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Structural covariance of amygdala subregions is associated with trait aggression and endogenous testosterone in healthy individuals

Cited by 6 publications

References 84 publications

The Predictive Value of Monocyte/High-Density Lipoprotein Ratio (MHR) and Positive Symptom Scores for Aggression in Patients with Schizophrenia

The Predictive Value of Monocyte/High-Density Lipoprotein Ratio (MHR) and Positive Symptom Scores for Aggression in Patients with Schizophrenia

Representational similarity analysis of self‐ versus other‐processing: Effect of trait aggressiveness

Occurrence, analysis and removal of pesticides, hormones, pharmaceuticals, and other contaminants in soil and water streams for the past two decades: a review

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