Structural damage in rheumatoid arthritis assessed by musculoskeletal ultrasound: A systematic literature review by the Structural Joint Damage Task Force of the OMERACT Ultrasound Working Group

Gessl, Irina; Bálint, Péter; Filippucci, Emilio; Keen, Helen; Pineda, Carlos; Terslev, Lene; Wildner, Brigitte; D'Agostino, Maria Antonietta; Mandl, Péter

doi:10.1016/j.semarthrit.2021.02.010

Cited by 7 publications

(3 citation statements)

References 128 publications

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“…To date, systematic literature reviews of ultrasonographic cartilage assessment in RA have included studies conducted by the OMERACT US WG for the development of a semiquantitative US scoring system [ 17 ] and assessment of the evidence for the use of US in structural joint damage in patients with RA [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…To date, cartilage evaluation using US has mainly been performed by quantitative evaluation based on thickness measurement and by binary evaluation based on the presence or absence of cartilage damage or graded semi-quantitative evaluation. However, in previous studies [ 5 ], the evaluation methods varied, and it is unclear which method is valid and valuable. Data are also lacking on their distinguishing abilities from other cartilage-damaging diseases, such as osteoarthritis (OA) and their usefulness as a monitoring tool in patients with RA.…”

Section: Introductionmentioning

confidence: 99%

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Cartilage evaluation by ultrasonography in patients with rheumatoid arthritis: a scoping review

2023

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Background This study aimed to provide an overview of ultrasonographic cartilage evaluation in patients with rheumatoid arthritis (RA) and identify research gaps in the utilization of cartilage evaluation. Methods The study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guidelines. A systematic literature search of the PubMed, Embase, and Cochrane Library databases was conducted for articles published up to July 2022 using the search term variations of “cartilage,” “ultrasonography,” and “rheumatoid arthritis.” Studies that included patients with RA who underwent cartilage evaluation by ultrasonography were selected. Articles published in languages other than English and about juvenile idiopathic arthritis were excluded. Results Twenty-nine articles were identified. Most were cross-sectional studies (86%), mainly involving the metacarpophalangeal (55%) and knee (34%) joints. Assessments were performed using quantitative, binary, and semi-quantitative methods in 15, 10, and 15 studies, respectively. Reliability assessments were conducted in 10 studies, which showed feasible reliability but were limited to the finger joints. The validity assessment was validated in one study each that compared cartilage thickness measurements with cadaveric specimens and histological and semi-quantitative methods with surgical specimens, respectively. Comparisons with conventional radiography were also performed in six studies, which showed significant correlations. However, there was heterogeneity in the examination and assessment methods, and no adequate longitudinal evaluation was conducted. Conclusion This review highlights the need for further research and validation of ultrasonographic cartilage assessment in patients with RA.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cartilage evaluation by ultrasonography in patients with rheumatoid arthritis: a scoping review

2023

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“…Apart from the relatively small sample size, we have only imaged the bilateral hand joints although the wrists and the small joints of the hands (e.g. MCPJs and PIPJs) are among the most commonly affected joint sites in patients with RA [31][32][33] . In our study, both thermal and ultrasound imaging were studied in relation to patients' RA disease activity states at a single time-point using a cross-sectional study design.…”

Section: P-valuementioning

confidence: 99%

Receiver operating characteristic analysis using a novel combined thermal and ultrasound imaging for assessment of disease activity in rheumatoid arthritis

Tan

Hong

et al. 2022

Sci Rep

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We aim to determine whether combined thermal and ultrasound (CTUS) imaging can identify rheumatoid arthritis (RA) patients with at least moderate disease activity (DAS28 > 3.2). Temperature differences of maximum (Tmax), average (Tavg) and minimum (Tmin) temperatures from a control temperature at 22 joints (bilateral hands) were summed up to derive the respective MAX, AVG and MIN per patient. MAX (PD), AVG (PD) and MIN (PD) are CTUS results derived by multiplying MAX, AVG and MIN by a factor of 2 when a patient’s total ultrasound power Doppler (PD) joint inflammation score > median score, which otherwise remained unchanged. Receiver operating characteristic (ROC) analysis was used to determine whether CTUS imaging can identify patients with DAS28 > 3.2. In this cross-sectional study, 814 joints were imaged among 37 RA patients (mean disease duration, 31 months). CTUS (but not single modality) imaging parameters were all significantly greater comparing patients with DAS28 > 3.2 versus those with DAS28 ≤ 3.2 (all P < 0.01). Area under the ROC curves (AUCs) using cut-off levels of ≥ 94.5, ≥ 64.6 and ≥ 42.3 in identifying patients with DAS28 > 3.2 were 0.73 , 0.76 and 0.76 for MAX (PD), AVG (PD) and MIN (PD), respectively (with sensitivity ranging from 58 to 61% and specificity all 100%). The use of CTUS in detecting a greater severity of joint inflammation among patients with at least moderate disease activity (DAS28 > 3.2) appears promising and will require further validation in independent RA cohorts.

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MUW researcher of the month

2023

Wien Klin Wochenschr

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Structural damage in rheumatoid arthritis assessed by musculoskeletal ultrasound: A systematic literature review by the Structural Joint Damage Task Force of the OMERACT Ultrasound Working Group

Cited by 7 publications

References 128 publications

Cartilage evaluation by ultrasonography in patients with rheumatoid arthritis: a scoping review

Cartilage evaluation by ultrasonography in patients with rheumatoid arthritis: a scoping review

Receiver operating characteristic analysis using a novel combined thermal and ultrasound imaging for assessment of disease activity in rheumatoid arthritis

MUW researcher of the month

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