Structural determination of abutilins A and B, new flavonoids from <i>Abutilon pakistanicum</i>, by 1D and 2D NMR spectroscopy

Ali, Bakhat; Imran, Muhammad; Hussain, Riaz; Ahmed, Zaheer; Malik, Abdul

doi:10.1002/mrc.2546

Cited by 10 publications

(6 citation statements)

References 17 publications

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“…( m / z 503→461) and the hexose fragment ( m / z 461→299). The existence of several O -acetyl-hexosides of chrysoeriol, including 7- O -(6′′- O -acetyl)glucoside from Sideritis lanata L. (Lamiaceae) [47], 4′- O -(2′′- O -acetyl)glucoside (abutilin A) from Abutilon pakistanicum Jafri and Ali (Malvaceae) [48] and 4′- O -(6′′- O -acetyl) glucoside from Onobrychis viciifolia Scop. (Leguminosae) [43], is known.…”

Section: Resultsmentioning

confidence: 99%

Caffeoylquinic Acids and Flavonoids of Fringed Sagewort (Artemisia frigida Willd.): HPLC-DAD-ESI-QQQ-MS Profile, HPLC-DAD Quantification, in Vitro Digestion Stability, and Antioxidant Capacity

et al. 2019

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Fringed sagewort (Artemisia frigida Willd., Compositae family) is a well-known medicinal plant in Asian medical systems. Fifty-nine hydroxycinnamates and flavonoids have been found in A. frigida herbs of Siberian origin by high-performance liquid chromatography with diode array and electrospray triple quadrupole mass detection (HPLC-DAD-ESI-QQQ-MS). Their structures were determined after mass fragmentation analysis as caffeoylquinic acids, flavone O-/C-glycosides, flavones, and flavonol aglycones. Most of the discovered components were described in A. frigida for the first time. It was shown that flavonoids with different types of substitution have chemotaxonomic significance for species of Artemisia subsection Frigidae (section Absinthium). After HPLC-DAD quantification of 16 major phenolics in 21 Siberian populations of A. frigida and subsequent principal component analysis, we found substantial variation in the selected compounds, suggesting the existence of two geographical groups of A. frigida. The antioxidant activity of A. frigida herbal tea was determined using 2,2-diphenyl-1-picrylhydrazyl free radical (DPPH•) and hydrophilic/lipophilic oxygen radical absorbance capacity (ORAC) assays and DPPH•-HPLC profiling, revealing it to be high. The effect of digestive media on the phenolic profile and antioxidant capacity of A. frigida herbal tea was assessed under simulated gastrointestinal digestion. We found a minor reduction in caffeoylquinic acid content and ORAC values, but remaining levels were satisfactory for antioxidant protection. These results suggest that A. frigida and its food derivate herbal tea could be recommended as new plant antioxidants rich in phenolics.

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Section: Resultsmentioning

confidence: 99%

Caffeoylquinic Acids and Flavonoids of Fringed Sagewort (Artemisia frigida Willd.): HPLC-DAD-ESI-QQQ-MS Profile, HPLC-DAD Quantification, in Vitro Digestion Stability, and Antioxidant Capacity

et al. 2019

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“…A. indicum Chrysoeriol-7-O-β-glupyranoside [19] Flowers A. indicum Apigenin-7-O-β-glupyranoside [20] Whole plant A. pannosum Apigenin-7-O-β-D(6''-p-coumaroyl) glucopyranoside [134] Whole plant A. pakistanicum 5,7,4'-Trihydroxy-3'-methoxy flavone-4'-O-β-D-(2"-O-acetyl) glucopyranoside [28] Whole plant A. pakistanicum Scutellarein-4'-O-α-L- […”

Section: Flowers Leavesmentioning

confidence: 99%

Phytochemistry and pharmacological activities of genus Abutilon: a review (1972-2015)

Gomaa

Samy

Desoukey

et al. 2018

Journal of advanced Biomedical and Pharmaceutical Sciences

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Abutilon Miller is a genus belonging to family Malvaceae comprises about 150 species. The plants of this genus are annual or perennial herbs, shrubs or even small trees. It is native to the tropical and subtropical countries of America, Africa, Asia and Australia. The genus has a significant importance, which is attributed to valuable insoluble fibers obtained from different species of the genus such as Abutilon theophrasti and also due to several species grown as garden ornamental plants such as A. ochsenii and A. vitifolium. Reviewing the available literature on genus Abutilon revealed the presence of a diversity of secondary metabolites such as flavonoids, phenolic acids, sterols, triterpenes, quinones, coumarins, alkaloids, sphingolipids, megastigmanes, iridoids and others, which are responsible for its biological activities such as anti

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“…42 -7.38 (m, 3H), 6.51 (d, J = 15.9, 1H, H-α) and 13 2 Hz, H-2'), 6.9 (d, J = 8.3 Hz, H-5'), 6.8 (d, J = 2.2 Hz, H-8), 6.7 (s, H-3), 6.4 (d, J = 2.2 Hz, H-6) and signal appeared as doublet at d ppm 5.08 (d, J = 6.6 Hz, H-1'' of glucose) assignable for the anomeric proton of the sugar moiety and 13 C-NMR spectrum (DMSO-d 6 ). 13 3) [31].…”

Section: All Collected Fraction Was Investigated Individually By Tlc ...mentioning

confidence: 99%

Musa Acuminata Wastes as New Potential source of Anti-ulcerative Colitis Agents : Pharmacological and Metabolomics Profiles

Mohammed

Ibrahim

Abdelatif

et al. 2022

Preprint

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Musa acuminata is a popular fruit in the world. Non-food parts of the plant have been investigated for their antioxidant and anti-ulcerative colitis activity. Metabolomic approaches was found to be informative as a screening tool. It discovered different metabolites depending on statistical analysis. The antioxidant activity content was measured by colorimetric method. Seventy six investigated metabolites were observed. The identities of some of these markers were confirmed based on their MS2 fragmentation and NMR spectroscopy. These include: Cinnamic acid and its dimer 2-hydroxy-4-(4-methoxyphenyl)-1H-phenalen-1-one beside Gallic acid and flavonoids; Quercetin, Quercetin-3-O-β-D-glucoside, Luteolin-7-O-β-D-glucopyranoside. The leaves, pseudostem and fruit peels extracts were tested for their safety and their antiUlcerative-colitis efficacy in rats. Rats were classified into:Normal, Positive, prednisolone reference group , Musa extracts pretreated groups(250-500mg/kg) for two weeks followed by induction of Ulcerative-colitis by per-rectal infusion of 8% acetic acid. Macroscopic and microscopic examination were done. Inflammatory markers (ANCA, CRP and Ilβ6) were measured in sera. The extracts showed good antioxidant and anti-inflammatory activities as they ameliorated macroscopic and microscopic signs of Ulcerativecolitis and lowered the inflammatory markers compared to untreated group. Musa wastes can be a potential source of bioactive metabolites for industrial use and future employment as promising anti-Ulcerativecolitis food supplements.

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Structural determination of abutilins A and B, new flavonoids from Abutilon pakistanicum, by 1D and 2D NMR spectroscopy

Cited by 10 publications

References 17 publications

Caffeoylquinic Acids and Flavonoids of Fringed Sagewort (Artemisia frigida Willd.): HPLC-DAD-ESI-QQQ-MS Profile, HPLC-DAD Quantification, in Vitro Digestion Stability, and Antioxidant Capacity

Caffeoylquinic Acids and Flavonoids of Fringed Sagewort (Artemisia frigida Willd.): HPLC-DAD-ESI-QQQ-MS Profile, HPLC-DAD Quantification, in Vitro Digestion Stability, and Antioxidant Capacity

Phytochemistry and pharmacological activities of genus Abutilon: a review (1972-2015)

Musa Acuminata Wastes as New Potential source of Anti-ulcerative Colitis Agents : Pharmacological and Metabolomics Profiles

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