Structural differences between the alkali-extracted water-soluble cell wall polysaccharides from mycelial and yeast phases of the pathogenic dimorphic fungus Paracoccidioides brasiliensis

Ahrazem, Oussama; Prieto, Alicia; San-Blas, Gioconda; Leal, Juan; Jiménez‐Barbero, Jesús; Bernabé, Manuel

doi:10.1093/glycob/cwg069

Cited by 27 publications

(17 citation statements)

References 30 publications

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“…1) and its structure can be determined. The α‐mannan cores from some of the polysaccharides investigated have been studied, and they display fairly similar structures, always containing a main chain of α‐(1→6)‐ d ‐mannose units more or less substituted by α‐mannose side chains (Prieto et al , 1997, 2001, 2002; Leal & Bernabé, 1998; Ahrazem et al , 1999, 2000a, b, 2003a; Domenech et al , 1999, 2002; Pereyra et al , 2003; Gómez‐Miranda et al , 2004). They resemble those described for some mannans from yeast mannoproteins (Fleet, 1991), which could suggest that they are a relic of the ancestral wall polysaccharide of the Ascomycota .…”

Section: Cell Wall Heteromannans (F1ss)mentioning

confidence: 99%

An assessment of fungal wall heteromannans as a phylogenetically informative character in ascomycetes

et al. 2010

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The fungal wall contains a small proportion of alkali-extractable water-soluble heteromannans (F1SS). They are the glycidic moiety of glycoproteins that have important roles in the biology of fungi. A considerable number of these polysaccharides has been described, differing in composition or linkage types. Their structure is similar in all species of a well-delimited genus, and teleomorphs and their corresponding anamorphs. Therefore, these polysaccharides have been used as chemotaxonomic markers at the genus level. Here we review cases where they have been found to resolve relationships around the genus level, and assess their phylogenetic informativeness in the delineation of taxa at family and higher ranks in the ascomycetes by comparison with molecular trees. Generally, the correlation is extremely good, from the species to the class level, though there are some divergences. In particular, comparisons suggest that the concept of the Sordariomycetes may eventually require revision as more molecular data become available. An analysis of the different chemical structures of these polysaccharides can lead to the proposal and testing of phylogenetic hypotheses, in a parallel manner to those generated from molecular trees. These molecules serve as an independent character similar to morphological or molecular characters.

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Section: Cell Wall Heteromannans (F1ss)mentioning

confidence: 99%

An assessment of fungal wall heteromannans as a phylogenetically informative character in ascomycetes

et al. 2010

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“…7 The fact that D-Galf is essential for the survival or virulence of various pathogenic bacteria, 8,9 but is absent in higher eukaryotes, prompted investigation on its biosynthetic pathways. 9,10 Therefore, the synthesis of oligosaccharides and conjugates containing D-Galf units 11 as tools in glycobiology is an area of active research.…”

Section: Introductionmentioning

confidence: 99%

Facile Synthesis of per-O-tert-Butyldimethylsilyl-β-d-galactofuranose and Efficient Glycosylation via the Galactofuranosyl Iodide

Baldoni

Marino

2009

J. Org. Chem.

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The synthesis of crystalline per-O-TBS-beta-D-galactofuranose (4beta) as a new precursor of D-Gal f units is described. Anomeric iodination by reaction with TMSI followed by in situ coupling with simple alcohols and a wide variety of glycosyl acceptors, in the absence of a promoter, was employed as a new efficient glycosylation method for the assembly of D-galactofuranosyl moieties with high beta-stereoselectivity. Under the mild conditions of this reaction labile protective groups, like acetals, and furanosyl linkages are preserved.

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“…The galactomannan backbone has long α-1,6-Man p chains, which in hyphae are mostly decorated with α-1,6-Man p -α-1,2-Gal f ramifications (Ahrazem et al, 2003). In yeasts, these are minor structures, while β-1,6-Gal f -α-1,2-Man p and α-1,2-Man p prevail.…”

mentioning

confidence: 99%

The Paracoccidioides Cell Wall: Past and Present Layers Toward Understanding Interaction with the Host

Puccia¹,

Vallejo²,

Matsuo³

et al. 2011

Front. Microbio.

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The cell wall of pathogenic fungi plays import roles in the interaction with the host, so that its composition and structure may determine the course of infection. Here we present an overview of the current and past knowledge on the cell wall constituents of Paracoccidioides brasiliensis and P. lutzii. These are temperature-dependent dimorphic fungi that cause paracoccidioidomycosis, a systemic granulomatous, and debilitating disease. Focus is given on cell wall carbohydrate and protein contents, their immune-stimulatory features, adhesion properties, drug target characteristics, and morphological phase specificity. We offer a journey toward the future understanding of the dynamic nature of the cell wall and of the changes that may occur when the fungus infects the human host.

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Structural differences between the alkali-extracted water-soluble cell wall polysaccharides from mycelial and yeast phases of the pathogenic dimorphic fungus Paracoccidioides brasiliensis

Cited by 27 publications

References 30 publications

An assessment of fungal wall heteromannans as a phylogenetically informative character in ascomycetes

An assessment of fungal wall heteromannans as a phylogenetically informative character in ascomycetes

Facile Synthesis of per-O-tert-Butyldimethylsilyl-β-d-galactofuranose and Efficient Glycosylation via the Galactofuranosyl Iodide

The Paracoccidioides Cell Wall: Past and Present Layers Toward Understanding Interaction with the Host

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