Structural diversity and applications of lipopeptide biosurfactants as biocontrol agents against phytopathogens: A review

Sani, Asma; Qin, Wan-Qi; Li, Jia-Yi; Liu, Yi-Fan; Zhou, Lei; Yang, Shi-Zhong; Mu, Bo-Zhong

doi:10.1016/j.micres.2023.127518

Cited by 13 publications

(7 citation statements)

References 86 publications

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“…Altering the surfactin homologue composition in B. subtilis Q1 by overexpressing the glutamine synthetase gene glnA further supports this view. Lipopeptides have structural diversity and broad functional capabilities, allowing them to be used in a variety of applications [ 35 ]. Cyclic lipopeptides such as surfactin, iturin, fengycin and lichenysin, which have a similar structure, have shown their best activity in industrial, environmental and medical applications [ 36 – 38 ].…”

Section: Discussionmentioning

confidence: 99%

Regulation mechanism and bioactivity characteristic of surfactin homologues with C14 and C15 fatty acid chains

Su,

Gao,

et al. 2024

Microb Cell Fact

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Background Surfactin, a green lipopeptide bio-surfactant, exhibits excellent surface, hemolytic, antibacterial, and emulsifying activities. However, a lack of clear understanding of the synthesis regulation mechanism of surfactin homologue components has hindered the customized production of surfactin products with different biological activities. Results In this study, exogenous valine and 2-methylbutyric acid supplementation significantly facilitated the production of C14–C15 surfactin proportions (up to 75% or more), with a positive correlation between the homologue proportion and fortified concentration. Subsequently, the branched-chain amino acid degradation pathway and the glutamate synthesis pathway are identified as critical pathways in regulating C14–C15 surfactin synthesis by transcriptome analysis. Overexpression of genes bkdAB and glnA resulted in a 1.4-fold and 1.3-fold increase in C14 surfactin, respectively. Finally, the C14-rich surfactin was observed to significantly enhance emulsification activity, achieving an EI24 exceeding 60% against hexadecane, while simultaneously reducing hemolytic activity. Conversely, the C15-rich surfactin demonstrated an increase in both hemolytic and antibacterial activities. Conclusion This study presents the first evidence of a potential connection between surfactin homologue synthesis and the conversion of glutamate and glutamine, providing a theoretical basis for targeting the synthesis regulation and structure–activity relationships of surfactin and other lipopeptide compounds. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Regulation mechanism and bioactivity characteristic of surfactin homologues with C14 and C15 fatty acid chains

Su,

Gao,

et al. 2024

Microb Cell Fact

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“…Fengycin consists of cyclic decapeptides linked to a β-hydroxy fatty acid chain through an inner ester bond. It contains a number of variants, including fengycin A and B [ 84 ]. The most common Pseudomonas lipopeptides include viscosin, amphisin, tolaasin, and syringomycin.…”

Section: Surfactant Classificationsmentioning

confidence: 99%

The Physicochemical and Functional Properties of Biosurfactants: A Review

Dini,

Bekhit,

Roohinejad

et al. 2024

Molecules

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Surfactants, also known as surface-active agents, have emerged as an important class of compounds with a wide range of applications. However, the use of chemical-derived surfactants must be restricted due to their potential adverse impact on the ecosystem and the health of human and other living organisms. In the past few years, there has been a growing inclination towards natural-derived alternatives, particularly microbial surfactants, as substitutes for synthetic or chemical-based counterparts. Microbial biosurfactants are abundantly found in bacterial species, predominantly Bacillus spp. and Pseudomonas spp. The chemical structures of biosurfactants involve the complexation of lipids with carbohydrates (glycolipoproteins and glycolipids), peptides (lipopeptides), and phosphates (phospholipids). Lipopeptides, in particular, have been the subject of extensive research due to their versatile properties, including emulsifying, antimicrobial, anticancer, and anti-inflammatory properties. This review provides an update on research progress in the classification of surfactants. Furthermore, it explores various bacterial biosurfactants and their functionalities, along with their advantages over synthetic surfactants. Finally, the potential applications of these biosurfactants in many industries and insights into future research directions are discussed.

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“…Lipopeptides can modify the hydrophobicity of surfaces, making them more hydrophobic, and they interact with some mineral surfaces, making them valuable in various industrial applications, including the detergent, cosmetics, cleaning products and metallurgy industries [144][145][146][147][148][149][150][151].…”

Section: Lipopeptidesmentioning

confidence: 99%

Biosurfactants: An Overview of Their Properties, Production, and Application in Mineral Flotation

Simões,

da Silva,

de Souza

et al. 2024

Resources

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The quest for sustainable mining processes has directed research towards environmentally friendly alternatives to conventional beneficiation practices, with biosurfactants emerging as a viable option due to their lower environmental impact. This study reviews the application of biosurfactants as bioreagents in mineral flotation, exploring their production, their mechanisms of action, and the sustainability benefits they offer. Methods include a decade-long text mining analysis of relevant literature, utilizing software tools like Zotero on platforms like Web of Science to extract and analyze data. The results underscore the growing interest in biosurfactants over the last ten years, highlighting their increasing relevance in industrial applications such as mineral flotation, where they replace synthetic surfactants. Particularly, biosurfactants have shown effectiveness in enhancing the froth flotation process, leading to more efficient mineral recovery while mitigating environmental harm. In conclusion, the adoption of biosurfactants in mineral processing not only aligns with sustainability goals but also demonstrates potential improvements in operational efficiency, offering a dual benefit of environmental protection and enhanced resource recovery.

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Structural diversity and applications of lipopeptide biosurfactants as biocontrol agents against phytopathogens: A review

Cited by 13 publications

References 86 publications

Regulation mechanism and bioactivity characteristic of surfactin homologues with C14 and C15 fatty acid chains

Regulation mechanism and bioactivity characteristic of surfactin homologues with C14 and C15 fatty acid chains

The Physicochemical and Functional Properties of Biosurfactants: A Review

Biosurfactants: An Overview of Their Properties, Production, and Application in Mineral Flotation

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