Structural diversity and luminescence of zinc coordination polymers constructed by flexible ligands

Li, Rui; Li, Jiaqi; Liu, Yong-Yao; He, Xiang

doi:10.1016/j.molstruc.2023.135183

“…Due to these varieties, it accesses various arrangements, such as a great assortment of frameworks, from monodentate to hexadentate chelates [120]. As a result, it forms ligands with multiple zinc clusters containing two to four ions in the metal intra-sphere binding geometry [121] and frequently forms dimeric or polymeric species [64]. Their stereochemistry dominates, with octahedrons in solutions, tetrahedrons in proteins, and a few distorted trigonal bipyramidon examples [122].…”

Section: Copper and Zinc In Chelating Structuresmentioning

confidence: 99%

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Zaidi¹,

Miskon²

2023

Preprint

0

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Due to its built-up chemoresistance after prolonged usage, the demand for replacing platinum in metal-based drugs (MBD) is rising. The first MBD approved by the FDA for cancer therapy was cisplatin in 1978. Even after nearly four and a half decades of trials, there has been no significant improvement in osteosarcoma (OS) therapy. In fact, many MBD have been developed, but the chemoresistance problem raised by platinum remains unresolved. This motivates us to elucidate the possibilities of the copper and zinc (CuZn) combination to replace platinum in MBD. Thus, the anti-chemoresistance properties of CuZn and their physiological functions for OS therapy are highlighted. Herein, we summarise their chelators, main organic solvents, and ligand functions in their structures that are involved in anti-chemoresistance properties. Through this review, it is rational to discuss their ligands’ roles as biosensors in drug delivery systems. Hereafter, an in-depth understanding of their redox and photoactive function relationships is provided. The disadvantage is that the other functions of biosensors cannot be elaborated on here. As a result, this review is being developed, which is expected to intensify OS drugs with higher cure rates. Nonetheless, this advancement intends to solve the major chemoresistance obstacle towards clinical efficacy.

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“…Due to these varieties, it accesses various arrangements, such as a great assortment of frameworks, from monodentate to hexadentate chelates [ 115 ]. As a result, it forms ligands with multiple zinc clusters containing two to four ions in the metal intra-sphere-binding geometry [ 116 ] and frequently forms dimeric or polymeric species [ 61 ]. Their stereochemistry dominates, with octahedrons in solutions, tetrahedrons in proteins, and a few distorted trigonal bipyramidon examples [ 117 ].…”

Section: Copper Zinc and Cuzn Structures In Anti-chemoresistancementioning

confidence: 99%

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Zaidi

¹

,

Miskon

²

2023

Molecules

17

0

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Due to its built-up chemoresistance after prolonged usage, the demand for replacing platinum in metal-based drugs (MBD) is rising. The first MBD approved by the FDA for cancer therapy was cisplatin in 1978. Even after nearly four and a half decades of trials, there has been no significant improvement in osteosarcoma (OS) therapy. In fact, many MBD have been developed, but the chemoresistance problem raised by platinum remains unresolved. This motivates us to elucidate the possibilities of the copper and zinc (CuZn) combination to replace platinum in MBD. Thus, the anti-chemoresistance properties of CuZn and their physiological functions for OS therapy are highlighted. Herein, we summarise their chelators, main organic solvents, and ligand functions in their structures that are involved in anti-chemoresistance properties. Through this review, it is rational to discuss their ligands’ roles as biosensors in drug delivery systems. Hereafter, an in-depth understanding of their redox and photoactive function relationships is provided. The disadvantage is that the other functions of biosensors cannot be elaborated on here. As a result, this review is being developed, which is expected to intensify OS drugs with higher cure rates. Nonetheless, this advancement intends to solve the major chemoresistance obstacle towards clinical efficacy.

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“…Bestowing greater thermal stability compared to their organic counterparts, these materials become chameleons upon interaction with organic ligands. [16][17][18][19] Derived from the realm of natural amino acids, these chiral organic ligands bear functional groups, including amides, carboxylates, and aromatic rings, weaving intricate tapestries of hydrogen bonds or 𝜋-𝜋 stacking interactions. Simultaneously, they play dual roles as coordination sites to d 10 metal cations and as chromophores, including electronic transitions (𝜋-𝜋* and/or n-𝜋*) crucial for light-emitting materials.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Chiral d¹⁰‐Metal Coordination Polymers: Tunable Photoluminescence and Efficient Second‐Harmonic Generation with Circular Dichroic Response

Lee,

Cho,

Li

et al. 2023

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4

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A series of homochiral coordination polymers (HCPs), [M2(SIAP)2(bpy)2] [M(S)] and [M2(RIAP)2(bpy)2] [M(R)] (M = Zn or Cd, SIAP or RIAP = (S,S)‐ or (R,R)‐ 2,2′‐(isophthaloylbis(azanediyl))di‐propionic acid, bpy = 4,4′‐bipyridine), is successfully synthesized through solvothermal reactions, self‐assembling d10 metal cations, chiral dicarboxylic ligands, and π‐conjugated bipyridyl ligands. The HCPs crystallize in the extremely rare triclinic chiral space group, P1, and present 3D framework structures attributed to the strong intermolecular interactions, such as hydrogen bonds and π–π stacking. Due to the unique crystal structures, the title compounds reveal efficient photoluminescence emission across a broad visible range, with significant brightness and color tuning by varying the excitation wavelength. Moreover, they exhibit efficient phase‐matched second‐harmonic generation (SHG) with very high laser‐induced damage thresholds, essential for high‐power nonlinear optical (NLO) applications. Intriguingly, the title compounds exhibit a measurable contrast in the SHG response under right‐ and left‐handed circularly polarized excitation, thereby providing a unique case of SHG circular dichroism from the chiral centers of SIAP2− or RIAP2− ligand packed in the noncentrosymmetric environment. These exceptional attributes position these HCPs as promising candidates for multifunctional materials, with potential applications ranging from NLO devices to tailored luminescent systems with polarization control.

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Structural diversity and luminescence of zinc coordination polymers constructed by flexible ligands

Cited by 7 publications

References 32 publications

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Multifunctional Chiral d¹⁰‐Metal Coordination Polymers: Tunable Photoluminescence and Efficient Second‐Harmonic Generation with Circular Dichroic Response

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Structural diversity and luminescence of zinc coordination polymers constructed by flexible ligands

Cited by 7 publications

References 32 publications

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Multifunctional Chiral d10‐Metal Coordination Polymers: Tunable Photoluminescence and Efficient Second‐Harmonic Generation with Circular Dichroic Response

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Product

Resources

About

Multifunctional Chiral d¹⁰‐Metal Coordination Polymers: Tunable Photoluminescence and Efficient Second‐Harmonic Generation with Circular Dichroic Response