Structural dynamics of tween-based microemulsions for antimuscarinic drug mirabegron

Nazar, Muhammad Faizan; Mujeed, Ayesha; Siddique, Muhammad Yasir; Zafar, Muhammad Nadeem; Saleem, M. A.; Khan, Asad Muhammad; Ashfaq, Muhammad; Sumrra, Sajjad Hussain; Zubair, Muhammad

doi:10.1007/s00396-020-04603-w

Cited by 18 publications

(12 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The electrolyte resistances estimated from the Cole–Cole plots were roughly 500, 600, and 700 Ω in the BME solutions with W/O BME values of 94/6, 77/23, and 40/60, respectively (Figure S4). These values are of almost the same order as those of other BMEs in previous reports. , Although these values were slightly large compared with that of 1 M NaNO 3 aqueous solution (water phase) (300 Ω), they are sufficiently low for electrochemical measurements.…”

Section: Resultssupporting

confidence: 83%

See 1 more Smart Citation

Lipophilic Vitamin E Diffusion through Bicontinuous Microemulsions

et al. 2021

View full text Add to dashboard Cite

We studied the diffusion properties of lipophilic vitamin E (VE) through bicontinuous microemulsions (BME) using both electrochemical and fluorescence correlation spectroscopy (FCS) measurements. We investigated the effect of different composition ratios of micro-water and micro-oil phases in BMEs (W/O BME ). When we employed the BME with a lower W/O BME value of 40/60 (oil-rich BME) as an electrolyte solution, we obtained a larger current response from VE at a fluorinated nanocarbon film electrode. Further voltammetric studies revealed that a higher VE diffusion coefficient was observed in the oil-rich BME. The FCS results also exhibited faster diffusion through the oil-rich BME, which played a significant role in accelerating the VE diffusion probably due to the widening of the micro-oil phase pathway in the BME. Moreover, the effect of increasing the VE diffusion was pronounced at the interface between the electrode surface and the BME solution. These results indicate that controlling the conditions of the BME as the measurement electrolyte is very effective for achieving superior electrochemical measurements in a BME.

show abstract

Section: Resultssupporting

confidence: 83%

“…These values are of almost the same order as those of other BMEs in previous reports. 22,23 Although these values were slightly large compared with that of 1 M NaNO 3 aqueous solution (water phase) (300 Ω), they are sufficiently low for electrochemical measurements.…”

Section: T H Imentioning

confidence: 94%

Lipophilic Vitamin E Diffusion through Bicontinuous Microemulsions

et al. 2021

View full text Add to dashboard Cite

show abstract

“…This is because the size of the BME structure is below the diffraction limit of light, although Nazar and co-workers successfully observed the BME structure (typically around 100 nm) with an optical microscope. 17,18 Nevertheless, the fluorescent images exhibited fluorescent signals based on both calcein and Nile red.…”

Section: Resultsmentioning

confidence: 99%

Lipophilic probe behavior in microemulsions evaluated by fluorescence correlation spectroscopy

et al. 2022

View full text Add to dashboard Cite

We evaluated the dispersion and diffusion of fluorescent-labeled lipophilic vitamin E (VE) in microemulsions (MEs) including water-in-oil (W/O) type ME, oil-in-water (O/W) type ME and bicontinuous ME (BME), by using fluorescence correlation spectroscopy (FCS). We prepared a fluorescent ATTO 488 or BODIPY group labeled VE (VE-ATTO or VE-BODIPY). VE-ATTO possesses lipophilic and hydrophilic parts, while VE-BODIPY consists solely of the lipophilic part. The VE-ATTO dissolved in heptane solution as an oil phase, appeared hot pink in color due to the solvatochromism effect under room light and almost no fluorescent signal, which was unlike the VE-ATTO dissolved in ME solutions and all the VE-BODIPY solutions (typical fluorescent green color). The FCS measurement rapidly proved that VE-BODIPY diffuses faster than VE-ATTO. This is presumably because the "surfactant-like" VE-ATTO is localized and trapped at the micro-water/micro-oil interface of the MEs, while the VE-BODIPY exists in the ME phase and macro-oil phase with good dispersion. These results demonstrate that FCS is a powerful tool for the rapid evaluation of the lipophilic probe behavior in heterogeneous ME solutions.

show abstract

“…Formulation A, which contains ethanol as a co-surfactant, yields a smaller droplet size with tiny size distribution, 46 while formulation B contains 1-propanol as a co-surfactant and produces bigger droplet size with dense size distribution. Droplets of small particle size provide a large surface area, which is responsible for enhanced distribution deeply into skin and higher mobility.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Enhanced delivery of lipophilic, hydrophilic, and amphiphilic drugs can be achieved through μE formulation. − The main advantages of μE formulations are considered to be the ingestion of a large amount and an enormous increase in the solubilization of the drug. The μE formulation also plays a critical role in the stability and absence of aggregation of the drug, which further corresponds to the steady-state release of the drug. − …”

Section: Introductionmentioning

confidence: 99%

Microemulsified Gel Formulations for Topical Delivery of Clotrimazole: Structural and In Vitro Evaluation

et al. 2021

Self Cite

View full text Add to dashboard Cite

Microemulsified gels (μEGs) with fascinating functions have become indispensable as topical drug delivery systems due to their structural flexibility, high stability, and facile manufacturing process. Topical administration is an attractive alternative to traditional methods because of advantages such as noninvasive administration, bypassing first-pass metabolism, and improving patient compliance. In this article, we report on the new formulations of microemulsion-based gels suitable for topical pharmaceutical applications using biocompatible and ecological ingredients. For this, two biocompatible μE formulations comprising clove oil/Brij-35/water/ethanol (formulation A) and clove oil/Brij-35/water/1-propanol (formulation B) were developed to encapsulate and improve the load of an antimycotic drug, Clotrimazole (CTZ), and further gelatinized to control the release of CTZ through skin barriers. By delimiting the pseudo-ternary phase diagram, optimum μE formulations with clove oil (∼15%) and Brij-35 (∼30%) were developed, keeping constant surfactant/co-surfactant ratio (1:1), to upheld 2.0 wt % CTZ. The as-developed formulations were further converted into smart gels by adding 2.0 wt % carboxymethyl cellulose (CMC) as a cross-linker to adhere to the controlled release of CTZ through complex skin barriers. Electron micrographs show a fine, monodispersed collection of CTZ-μE nanodroplets (∼60 nm), which did not coalesce even after gelation, forming spherical CTZ-μEG (∼90 nm). However, the maturity of CTZ nanodroplets observed by dynamic light scattering suggests the affinity of CTZ for the nonpolar microenvironment, which was further supported by the peak-to-peak correlation of Fourier transform infrared (FTIR) analysis and fluorescence measurement. In addition, HPLC analysis showed that the in vitro permeation release of CTZ-μEG from rabbit skin in the ethanolic phosphate buffer (pH = 7.4) was significantly increased by >98% within 6.0 h. This indicates the sustained release of CTZ in μEBG and the improvement in transdermal therapeutic efficacy of CTZ over its traditional topical formulations.

show abstract

Structural dynamics of tween-based microemulsions for antimuscarinic drug mirabegron

Cited by 18 publications

References 51 publications

Lipophilic Vitamin E Diffusion through Bicontinuous Microemulsions

Lipophilic Vitamin E Diffusion through Bicontinuous Microemulsions

Lipophilic probe behavior in microemulsions evaluated by fluorescence correlation spectroscopy

Microemulsified Gel Formulations for Topical Delivery of Clotrimazole: Structural and In Vitro Evaluation

Contact Info

Product

Resources

About