Structural elucidation and hypoglycemic effect of an inulin-type fructan extracted from <i>Stevia rebaudiana</i> roots

Tang, Zhiyan; Shao, Taili; Gao, Lan; Yuan, Ping; Ren, Zhengrui; Tian, Lei; Liu, Wei; Liu, Chunyan; Xu, Xianlei; Zhou, Xuan; Han, Jun Hyun; Wang, Guodong

doi:10.1039/d2fo03687h

Cited by 5 publications

(1 citation statement)

References 50 publications

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“…However, after 22 weeks of nutrition, a significant difference in perirenal fat mass and ratio between DM mice and DM-I mice was observed (Figure 1C,D). These findings are consistent with previous studies 12,13 and suggest that inulin supplementation reduces body weight and visceral fat in mice with high-fat diet-induced T2DM following STZ administration.…”

Section: ■ Resultssupporting

confidence: 93%

Inulin Inhibits the Inflammatory Response through Modulating Enteric Glial Cell Function in Type 2 Diabetic Mellitus Mice by Reshaping Intestinal Flora

Li,

Duan,

Wang

et al. 2023

ACS Omega

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Inulin, a commonly used dietary fiber supplement, is capable of modulating the gut microbiome. Chronic inflammation resulting from metabolic abnormalities and gut flora dysfunction plays a significant role in the development of type 2 diabetes mellitus (T2DM). Our research has demonstrated that inulin administration effectively reduced colonic inflammation in T2DM mice by inducing changes in the gut microbiota and increasing the concentration of butyric acid, which in turn modulated the function of enteric glial cells (EGCs). Experiments conducted on T2DM mice revealed that inulin administration led to an increase in the Bacteroidetes/Firmicutes ratio and the concentration of butyric acid in the colon. The anti-inflammatory effects of altered gastrointestinal flora and its metabolites were further confirmed through fecal microbiota transplantation. Butyric acid was found to inhibit the activation of the κB inhibitor kinase β/nuclear factor κB pathway, regulate the expression levels of interleukin-6 and tumor necrosis factor-α, suppress the abnormal activation of EGCs, and prevent the release of inflammatory factors by EGCs. Similar results were observed in vitro experiments with butyric acid. Our findings demonstrate that inulin, by influencing the intestinal flora, modifies the activity of EGCs to effectively reduce colonic inflammation in T2DM mice.

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Section: ■ Resultssupporting

confidence: 93%

Inulin Inhibits the Inflammatory Response through Modulating Enteric Glial Cell Function in Type 2 Diabetic Mellitus Mice by Reshaping Intestinal Flora

Li,

Duan,

Wang

et al. 2023

ACS Omega

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show abstract

Structural elucidation of an active polysaccharide from Radix Puerariae lobatae and its protection against acute alcoholic liver disease

Cao,

Wu,

Zhao

et al. 2024

Carbohydrate Polymers

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Benefits of Stevia rebaudian root inulin on mice health in long-term exposure study

Liu,

Wang,

Yang

et al. 2024

Journal of Functional Foods

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Structural elucidation and hypoglycemic effect of an inulin-type fructan extracted from Stevia rebaudiana roots

Abstract: Diabetes mellitus (DM) is a common chronic medical condition characterized by hyperglycemia resulting from abnormal insulin functionality, of which type 2 DM (T2DM) is the predominant form. An inulin-type fructan,...

Cited by 5 publications

References 50 publications

Inulin Inhibits the Inflammatory Response through Modulating Enteric Glial Cell Function in Type 2 Diabetic Mellitus Mice by Reshaping Intestinal Flora

Inulin Inhibits the Inflammatory Response through Modulating Enteric Glial Cell Function in Type 2 Diabetic Mellitus Mice by Reshaping Intestinal Flora

Structural elucidation of an active polysaccharide from Radix Puerariae lobatae and its protection against acute alcoholic liver disease

Benefits of Stevia rebaudian root inulin on mice health in long-term exposure study

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