2020
DOI: 10.3390/antibiotics9060278
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Structural Elucidation of Antibiotic TKR2999, an Antifungal Lipodepsipeptide Isolated from the Fungus Foliophoma fallens

Abstract: An antifungal lipodepsipeptide was obtained from cultures of the fungus Foliophoma fallens CF-236885. Its structure, elucidated by HRMS and NMR spectroscopy, contained Gly, Thr, Asn, β-Ala, Orn, Ala, two Ser residues, and 3-hydroxy-4-methylhexadecanoic acid. The absolute configuration of its amino acid residues was determined using Marfey’s analysis and J-based configuration analysis helped to establish the relative configuration of the 3-hydroxy-4-methylhexadecanoic acid moiety. A literature search retrieved … Show more

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“…(12 %) and Foliophoma fallens (8 %). This later species has been associated with leaf spots in olive trees (Crous and Groenewald, 2017), also displaying antifungal activity (Crespo et al, 2020). The Leotiomycetes sequences were almost exclusively from the causal agent of olive leprosy, Neofabraea vagabunda (12 %).…”
Section: Composition Of Fungal Endophytic Communities Among Olive Cultivarsmentioning
confidence: 99%
“…(12 %) and Foliophoma fallens (8 %). This later species has been associated with leaf spots in olive trees (Crous and Groenewald, 2017), also displaying antifungal activity (Crespo et al, 2020). The Leotiomycetes sequences were almost exclusively from the causal agent of olive leprosy, Neofabraea vagabunda (12 %).…”
Section: Composition Of Fungal Endophytic Communities Among Olive Cultivarsmentioning
confidence: 99%