Structural elucidation of stress degradation products of ampicillin sodium by liquid chromatography/hybrid triple quadrupole linear ion trap mass spectrometry and liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry

Li, Tao; Xu, Xuanlin; Fu, Shanlin; Zhang, Juan; Zhang, Kerong; Wang, Shuang; Zhao, Mingwei; Ding, Weijing; Wang, Qiao

doi:10.1002/rcm.6970

Cited by 19 publications

(2 citation statements)

References 18 publications

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“…It is likely that the newly-formed carboxylic acid is highly reactive and either fragments to form the new compounds, as shown, or follows the pathway to the formation of the diketopiperazine. If the carboxylic acid is released as CO2, this could explain for the large signal at 259.0899 m/z, which has been observed as a fragment in previous MS studies in the literature [57]. All of this work can be summarized by the pathway shown in Figure 8.…”

Section: Mechanism Of Plasma Degradationmentioning

confidence: 56%

Mechanism of Ampicillin Degradation by Non-Thermal Plasma Treatment with FE-DBD

Smith

Adams

2017

Plasma

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This research focused on determining the effectiveness of non-thermal atmospheric pressure plasma as an alternative to advanced oxidation processes (AOP) for antibiotic removal in solution. For this study, 20 mM (6.988 g/L) solutions of ampicillin were treated with a floating electrode dielectric barrier discharge (FE-DBD) plasma for varying treatment times. The treated solutions were analyzed primarily using mass spectrometry (MS) and nuclear magnetic resonance spectroscopy (NMR). The preliminary product formed was Ampicillin Sulfoxide, however, many more species are formed as plasma treatment time is increased. Ampicillin was completely eliminated after five minutes of air-plasma treatment. The primary mechanism of ampicillin degradation by plasma treatment is investigated in this study.

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Section: Mechanism Of Plasma Degradationmentioning

confidence: 56%

Mechanism of Ampicillin Degradation by Non-Thermal Plasma Treatment with FE-DBD

Smith

Adams

2017

Plasma

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“…The explanation for these discordant results is not straightforward. Several works have aimed to characterize the degradation products of ampicillin by using different forced conditions (acidic and alkaline hydrolysis, hot, photolytic, and humid stress conditions) [ 52 ]. Acids, diketopiperazines, and dimers/trimers of AMP are some of the characterized degradation compounds.…”

Section: Discussionmentioning

confidence: 99%

Ampicillin Stability in a Portable Elastomeric Infusion Pump: A Step Forward in Outpatient Parenteral Antimicrobial Therapy

et al. 2023

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Outpatient parenteral antimicrobial therapy (OPAT) with continuous infusion pumps is postulated as a very promising solution to treat complicated infections, such as endocarditis or osteomyelitis, that require patients to stay in hospital during extended periods of time, thus reducing their quality of life and increasing the risk of complications. However, stability studies of drugs in elastomeric devices are scarce, which limits their use in OPAT. Therefore, we evaluated the stability of ampicillin in sodium chloride 0.9% at two different concentrations, 50 and 15 mg/mL, in an elastomeric infusion pump when stored in the refrigerator and subsequently in real-life conditions at two different temperatures, 25 and 32 °C, with and without the use of a cooling device. The 15 mg/mL ampicillin is stable for up to 72 h under refrigeration, allowing subsequent dosing at 25 °C for 24 h with and without a cooling device, but at 32 °C its concentration drops below 90% after 8 h. In contrast, 50 mg/mL ampicillin only remains stable for the first 24 h under refrigeration, and subsequent administration at room temperature is not possible, even with the use of a cooling system. Our data support that 15 mg/mL AMP is suitable for use in OPAT if the volume and rate of infusion are tailored to the dosage needs of antimicrobial treatments.

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Theoretical insights into the reaction mechanism and kinetics of ampicillin degradation with hydroxyl radical

Aydogdu

Hatipoğlu

2023

J Mol Model

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Structural elucidation of stress degradation products of ampicillin sodium by liquid chromatography/hybrid triple quadrupole linear ion trap mass spectrometry and liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry

Cited by 19 publications

References 18 publications

Mechanism of Ampicillin Degradation by Non-Thermal Plasma Treatment with FE-DBD

Mechanism of Ampicillin Degradation by Non-Thermal Plasma Treatment with FE-DBD

Ampicillin Stability in a Portable Elastomeric Infusion Pump: A Step Forward in Outpatient Parenteral Antimicrobial Therapy

Theoretical insights into the reaction mechanism and kinetics of ampicillin degradation with hydroxyl radical

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