The current pandemic has caused extraordinary and long-lasting work demands on nurses. Nurses spend more time accomplishing various responsibilities, including providing nursing care to patients, attending to the needs of the patient's family, and performing administrative functions. Nurses work tirelessly during their shifts, enduring faulty work environment conditions, inadequate protective resources, and situations that challenge them emotionally and mentally (Alsolais et al., 2021; WHO, 2020a). A previous study reported that nurses' professional quality of life is affected by their work experiences and conditions during this pandemic (Inocian et al., 2021).These situations for nurses have placed their well-being at work at risk. Nurses' self-efficacy to perform and execute at different levels in response to care for COVID-19 has likely decreased as compared to non-pandemic situations. Thus, they are putting their well-being at work at risk. Taking care of nurses' well-being directly affects their ability to fully serve their patients because negative well-being in the workplace brings consequences in areas such as performance, absenteeism, and staff turnover (WHO, 2020a). Although wellbeing is considered important for nurses, the relationship between self-efficacy among nurses during challenging situations, such as the COVID-19 pandemic, has rarely been assessed. The underlying mechanism of this relationship, especially during a pandemic, needs to be understood. Addressing the self-efficacy and overall wellbeing at work requires understanding the nature and extent of the effects of pandemics to ensure that effective interventions can be used to guarantee the optimum levels of nurses' well-being at work.Having optimum well-being at work among nurses and other healthcare workers is critical to ensuring the provision of high-quality and