Structural evaluation of three 2-phenylpyrazolo[4,3-c]quinolin-3-one monohydrates

Ferreira, Vı́tor F.; Leal, Kátia Zaccur; Lindgren, Eric B.; Oliveira, Mara Rita P. de; Souza, Maria C. B. V. de; Vasconcelos, Thatyana R. A.; Wardell, Jámes L.; Wardell, Solange M. S. V.; Yoneda, Julliane Diniz

doi:10.1016/j.molstruc.2013.08.032

Cited by 6 publications

(3 citation statements)

References 21 publications

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“…Although there are three tautomeric forms possible for such PQs, only the most stable tautomer in solution (keto tautomer shown in Scheme 1 ) was considered for the docking study 53 . The selection of the most favourable pose of each compound investigated was carried out by computing the total electrostatic and hydrophobic contributions of each pose to the interaction energy (IE).…”

Section: Resultsmentioning

confidence: 99%

Synthesis and preliminary structure-activity relationship study of 2-aryl-2H-pyrazolo[4,3-c]quinolin-3-ones as potential checkpoint kinase 1 (Chk1) inhibitors

Malvacio

Cuzzolin

Sturlese

et al. 2017

Journal of Enzyme Inhibition and Medicinal Chemistry

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The serine-threonine checkpoint kinase 1 (Chk1) plays a critical role in the cell cycle arrest in response to DNA damage. In the last decade, Chk1 inhibitors have emerged as a novel therapeutic strategy to potentiate the anti-tumour efficacy of cytotoxic chemotherapeutic agents. In the search for new Chk1 inhibitors, a congeneric series of 2-aryl-2 H-pyrazolo[4,3-c]quinolin-3-one (PQ) was evaluated by in-vitro and in-silico approaches for the first time. A total of 30 PQ structures were synthesised in good to excellent yields using conventional or microwave heating, highlighting that 14 of them are new chemical entities. Noteworthy, in this preliminary study two compounds 4e2 and 4h2 have shown a modest but significant reduction in the basal activity of the Chk1 kinase. Starting from these preliminary results, we have designed the second generation of analogous in this class and further studies are in progress in our laboratories.

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Section: Resultsmentioning

confidence: 99%

Synthesis and preliminary structure-activity relationship study of 2-aryl-2H-pyrazolo[4,3-c]quinolin-3-ones as potential checkpoint kinase 1 (Chk1) inhibitors

Malvacio

Cuzzolin

Sturlese

et al. 2017

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…One quinonoid derivatives; isotanshinoneⅡA was not previously reported in literature review as a component of STF ingredients. IsotanshinoneⅡA have demonstrated anti-inflammatory properties and are commonly used in Chinese herbal medicine as well as to remove blood stasis and [ 17 ]. One organic ester; dihydroxypropyl oleate was shown anti-inflammatory effect.…”

Section: Discussionmentioning

confidence: 99%

Metabolomic analysis of Thai Herbal Analgesic Formula based on ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry

Vannabhum

Ziangchin

Thepnorarat

et al. 2023

Heliyon

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“…there was shown in Chinese herbal medicine and used as remove blood stasis. Pharmacological effect of phytochemical group was shown anti-inflammation 40 . Organic esters group was identified as dihydroxypropyl oleate.…”

Section: Discussionmentioning

confidence: 99%

Untargeted Metabolomic Profiles of Thai Herbal Sahatsatara Formula by Mass Spectrometry

Ziangchin

Vannabhum

Thepnorarat

et al. 2021

Preprint

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Thai herbal Sahatsatara formula (STF) has been used for more than three decades to relieve musculoskeletal pain, numbness and anti-flatulence in Thai traditional medicine (TTM). STF composed of 21 ingredients. Black pepper is the major constituent in this formula. Previous studies revealed that piperine was used for quality control assessment of STF. However, only one biomarker is not enough to assure quality determination of the poly-herbal medicine. In this work we established untargeted metabolomic profiling of STF using Liquid Chromatography-Mass Spectrometry (LC-MS) and identification compounds with Traditional Chinese medicine (TCMs) library in UNIFI software. STF was extracted three concentrations. The untargeted metabolomics profiles of STF were represented A total of 21 natural products were detected in in all STF extract concentrations both positive and negative ionization modes Additionally, there were discovered new chemical markers for quality control. Moreover, the method was simplifying and reproducibility.

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Structural evaluation of three 2-phenylpyrazolo[4,3-c]quinolin-3-one monohydrates

Cited by 6 publications

References 21 publications

Synthesis and preliminary structure-activity relationship study of 2-aryl-2H-pyrazolo[4,3-c]quinolin-3-ones as potential checkpoint kinase 1 (Chk1) inhibitors

Synthesis and preliminary structure-activity relationship study of 2-aryl-2H-pyrazolo[4,3-c]quinolin-3-ones as potential checkpoint kinase 1 (Chk1) inhibitors

Metabolomic analysis of Thai Herbal Analgesic Formula based on ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry

Untargeted Metabolomic Profiles of Thai Herbal Sahatsatara Formula by Mass Spectrometry

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