Structural features and complement fixing activity of polysaccharides from Codonopsis pilosula Nannf. var. modesta L.T.Shen roots

Zou, Yuanfeng; Chen, Xingfu; Malterud, Karl Egil; Rise, Frode; Barsett, Hilde; Inngjerdingen, Kari Tvete; Michaelsen, Terje E.; Paulsen, Berit Smestad

doi:10.1016/j.carbpol.2014.07.036

Cited by 70 publications

(62 citation statements)

References 34 publications

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“…Peak at 80.3 ppm and 70.1 in low magnetic field appeared to come from C-3 and C6 resonance of Residue-B, respectively (Yang et al, 2016). On the contrary, three signals of 64.1, 62.9 and 63.9 at high magnetic filed seemed to unsubstituted C-6 of Residue A, C and C-5 of Residue D, respectively (Yan et al, 2013;Zou et a., 2014).…”

Section: Structural Identification Of the Polysaccharidementioning

confidence: 94%

“…The signal of substituted C-4 of Residues A had moved downfield to 80.9 ppm (Zou et al, 2014). Peak at 80.3 ppm and 70.1 in low magnetic field appeared to come from C-3 and C6 resonance of Residue-B, respectively (Yang et al, 2016).…”

Section: Structural Identification Of the Polysaccharidementioning

confidence: 98%

“…In the 13 C NMR spectrum of SP1, the peaks at 107.3, 103.6, 100.1 and 109.4 ppm attributed to the anomeric carbons of Residue A, B, C and D, respectively (Yan et al, 2013;Yang et al, 2016;Zou et al, 2014). The signal of substituted C-4 of Residues A had moved downfield to 80.9 ppm (Zou et al, 2014).…”

Section: Structural Identification Of the Polysaccharidementioning

confidence: 99%

See 2 more Smart Citations

A polysaccharide from Huaier induced apoptosis in MCF-7 breast cancer cells via down-regulation of MTDH protein

Luo

Xiong

et al. 2016

Carbohydrate Polymers

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Section: Structural Identification Of the Polysaccharidementioning

confidence: 94%

Section: Structural Identification Of the Polysaccharidementioning

confidence: 98%

See 1 more Smart Citation

A polysaccharide from Huaier induced apoptosis in MCF-7 breast cancer cells via down-regulation of MTDH protein

Luo

Xiong

et al. 2016

Carbohydrate Polymers

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“…Although BC is a typical herbal preparation and exhibits satisfactory efficacy for treating vitiligo, there are few investigations targeting the therapeutic material basis .On the basis of Chinese medicine theory, the BC prescription was designed to treat vitiligo by resolving Qi deficiency and blood stasis . It is well known that Codonopsis Pilosula , and Astragali Radix are often used as Qi invigorators ; Angelicae Sinensis Radix , Radix Paeoniae Rubra , and Atractylodes Macrocephala Rhizoma are often prescribed as blood circulation activators . In this study, we detected multiple chemicals of above‐mentioned herbs, which might be the active constituents of BC in treating vitiligo.…”

Section: Resultsmentioning

confidence: 81%

Identification of chemical components in Baidianling Capsule based on gas chromatography–mass spectrometry and high‐performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry

Wang

Chen

Wang

et al. 2017

J of Separation Science

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Baidianling Capsule, which is made from 16 Chinese herbs, has been widely used for treating vitiligo clinically. In this study, the sensitive and rapid method has been developed for the analysis of chemical components in Baidianling Capsule by gas chromatography-mass spectrometry in combination with retention indices and high-performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry. Firstly, a total of 110 potential volatile compounds obtained from different extraction procedures including alkanes, alkenes, alkynes, ketones, ethers, aldehydes, alcohols, phenols, organic acids, esters, furans, pyrrole, acid amides, heterocycles, and oxides were detected from Baidianling Capsule by gas chromatography-mass spectrometry, of which 75 were identified by mass spectrometry in combination with the retention index. Then, a total of 124 components were tentatively identified by high-performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry. Fifteen constituents from Baidianling Capsule were accurately identified by comparing the retention times with those of reference compounds, others were identified by comparing the retention times and mass spectrometry data, as well as retrieving the reference literature. This study provides a practical strategy for rapidly screening and identifying the multiple constituents of a complex traditional Chinese medicine.

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“…Recently, more and more attention has been paid to the study of polysaccharides from Radix Codonopsis. Several such polysaccharides are obtained from Radix Codonopsis and some exhibit potential bioactivities [ 2 , 3 , 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Structure Features and Anti-Gastric Ulcer Effects of Inulin-Type Fructan CP-A from the Roots of Codonopsis pilosula (Franch.) Nannf.

Wang

Zhu

et al. 2017

Molecules

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Radix Codonopsis has been used in traditional Chinese medicine for strengthening the immune system, improving poor gastrointestinal function, treating gastric ulcers and chronic gastritis and so on. In the present study, an inulin-type fructan CP-A was obtained from the roots of Codonopsis pilosula (Franch.) Nannf. and its structure was confirmed by MS and NMR as (2 → 1) linked-β-d-fructofuranose. The protective effects of CP-A against ethanol-induced acute gastric ulcer in rats were intensively investigated. A Lacy assay demonstrated that CP-A-treated group (50 mg/kg) showed the gastric damage level 1, which was similar to the positive control group, while the model group exhibited the gastric damage level 3. The Guth assay demonstrated that the mucosa ulcer index for CP-A groups at the doses of 50 mg/kg and 25 mg/kg significantly decreased compared with that in the model group (p < 0.05). Meanwhile, CP-A significantly increased the activities of SOD and GSH-Px, and decreased the contents of MDA and NO, and the activity of MPO in gastric tissue in a dose-dependent manner (p < 0.05). The present research reported for the first time that inulin-type fructan CP-A were likely the potential component in Radix Codonopsis for treatment of acute gastric ulcers.

show abstract

Structural features and complement fixing activity of polysaccharides from Codonopsis pilosula Nannf. var. modesta L.T.Shen roots

Cited by 70 publications

References 34 publications

A polysaccharide from Huaier induced apoptosis in MCF-7 breast cancer cells via down-regulation of MTDH protein

A polysaccharide from Huaier induced apoptosis in MCF-7 breast cancer cells via down-regulation of MTDH protein

Identification of chemical components in Baidianling Capsule based on gas chromatography–mass spectrometry and high‐performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry

Structure Features and Anti-Gastric Ulcer Effects of Inulin-Type Fructan CP-A from the Roots of Codonopsis pilosula (Franch.) Nannf.

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