Structural Features of Sulfated Glucuronomannan Oligosaccharides and Their Antioxidant Activity

Abstract

Glucuronomannan oligosaccharides (Gs) were derived from fucoidan, which was extracted from the brown alga Sargassum thunbergii. Sulfated glucuronomannan oligosaccharides (SGs) were obtained by the sulfation of Gs. NMR techniques were used to reveal that the order of sulfation was Man-C6 > Man-C4 > Man-C1R > GlcA-C3 > Man-C3 > GlcA-C2. Finally, the antioxidant activities (hydroxyl radical scavenging activity, superoxide radical scavenging activity, reducing power and DPPH radical scavenging activity) of Gs and SGs were determined. The findings showed that the higher the degree of polymerization, the better the activity, except for the hydroxyl radical scavenging activity. In addition, the higher the sulfate content, the lower the activities for the reducing power and DPPH radical scavenging activity. Opposite results were found for the superoxide radical scavenging activity. Finally, compared with fucoidan, most Gs and SGs had higher antioxidant activity, suggesting that they might be good candidates for antioxidants.

Preparation and Neuroprotective Activity of Glucuronomannan Oligosaccharides in an MPTP-Induced Parkinson’s Model

“…Results of HPLC analysis confirmed that GM1, GM2, GM3 and GM4 were relatively pure. Their structures were previously elucidated [ 21 , 22 ]. These glucuronomannan oligosaccharides were composed of a repeating disaccharide unit of 4-linked gluconic acid (GlcA) and 2-linked mannose (Man).…”

Biological Activities of Fucoidan and the Factors Mediating Its Therapeutic Effects: A Review of Recent Studies

“…Several factors determine the antioxidant activity of fucoidan, including concentration, Mw, the degree of sulphation, substitution groups and their positions, type of sugar, and glycosidation branching [59,60,61]. It has been shown that components isolated from brown algae exhibit ROS scavenging activity in a concentration-dependent manner [62].…”

Inhibition of SARS-CoV-2 Virus Entry by the Crude Polysaccharides of Seaweeds and Abalone Viscera In Vitro

“…SPSJ is a highly branched, partially acetylated, sulfated galactofucan, built up of (1→3)-α-L-fucose residues, while SPUP is a partially acetylated, highly sulfated galactofucan consisting of (1→3)- or (1→3); (1→4)-α- l -fucose residues [ 30 ]. Meanwhile, SPSH is established to consist mostly of the repeating → 3-α- l -Fuc p (2SO 3 − )-1 → 4-α- l -Fuc p (2,3SO 3 − )-1 → fragment with insertions of the →3-α- l -Fuc p (2,4SO 3 − )-1 → fragment and unsulfated side chains with the α-L-Fuc p -1 → 2-α- l -Fuc p -1 → structure connected to the main one at C4 of the monosaccharide residue [ 31 ]. SPCF is composed of highly sulfated 3-linked β- d -galactopyranose and β- l -arabinopyranose residues [ 32 ].…”