Structural features regulated photoluminescence intensity and cell internalization of carbon and graphene quantum dots for bioimaging

Choppadandi, Mounika; Guduru, Aditya Teja; Gondaliya, Piyush; Arya, Neha; Kalia, Kiran; Kumar, Hemant; Kapusetti, Govinda

doi:10.1016/j.msec.2021.112366

Cited by 39 publications

(14 citation statements)

References 85 publications

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“…The results demonstrated that N-CQDs and FA-NCQDs produced more chromatin damage than CB-CQDs, which have a lower toxicity. Additionally, the quantification analysis showed an increase in the number of cells associated with nuclear fragmentation, nuclear condensation, nuclear degradation, and rupture of the cell membrane, as shown in (Figures7 and 8)(Choppadandi et al, 2021;Karakoçak et al, 2020).…”

mentioning

confidence: 85%

Development and application of naturally derived, cost‐effective CQDs with cancer targeting potential

El-Borlsy

Hanafy

El‐Kemary

2023

Cell Biology International

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Carbon quantum dots (CQDs) derived from natural sources have obtained potential interest in biomedical imaging and therapy because of their excellent biocompatibility properties, which include water solubility, simple synthesis and low cytotoxicity. Here the cytotoxicity of ethylene‐diamine doped carbon quantum dots (N‐CQDs) delivered to breast cancer MCF‐7 cells was investigated. Folic acid was used to raise folate recognition and increase FA‐NCQD accumulation in the cells, then apoptosis was assayed using nuclear fragmentation, acridine orange labeling, fluorescence imaging, flow cytometry, and caspase 3 expression. The data show that functionalization of these CQDs, derived from a natural source, have potential application in eliminating cancer cells, as shown here for the invasive breast cancer cells, MCF‐7. This nano‐delivery system provides a novel target therapy possibility therapeutic approach for cancer cells.

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mentioning

confidence: 85%

Development and application of naturally derived, cost‐effective CQDs with cancer targeting potential

El-Borlsy

Hanafy

El‐Kemary

2023

Cell Biology International

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“…GQDs possess huge amounts of edge defects [101]. Recently, Choppadandi et al [86] revealed that the GQDs applied for bioimaging in his work showed zigzag edges as per the TEM and AFM analysis. Moreover, it has been reported that GQDs exhibit brighter PL due to the strong confined п electrons in the sp 2 clusters of crystalline carbon network followed by formation of zigzag or armchair edges, particle shape, functional groups, doping and defects.…”

Section: Other Defects Addition Of Heteroatoms/ Dopingmentioning

confidence: 98%

“…The in‐plane defects taking place during the synthesis process followed by the assimilation in sp 2 hexagons have not been reported, whereas GQDs possess huge amounts of edge defects [101]. Recently, Choppadandi et al [86] revealed that the GQDs applied for bioimaging in his work showed zigzag edges as per the TEM and AFM analysis.…”

Section: How Are Structural Defects Generatedmentioning

confidence: 99%

“…Moreover, it has been reported that GQDs exhibit brighter PL due to the strong confined п electrons in the sp 2 clusters of crystalline carbon network followed by formation of zigzag or armchair edges, particle shape, functional groups, doping and defects. They also stated that PL has initiated in GQDs owing to the intense edge defects and surface traps, other than quantum confinement effect [86].…”

Section: How Are Structural Defects Generatedmentioning

confidence: 99%

“…Originates from zigzag and armchair edges [76] TEM and AFM characterization [86] • Strong confined п electrons in the sp 2 clusters of crystalline carbon network followed by formation of zigzag or armchair edges, particle shape, functional groups, doping and defects…”

Section: Edge Defectsmentioning

confidence: 99%

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Structural defects in graphene quantum dots: A review

Rabeya

Mahalingam

Manap

et al. 2022

Int J of Quantum Chemistry

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Graphene quantum dots (GQDs) are known for their low toxicity, strong fluorescence, high surface area, large solubility, and tunable band gaps. However, the change in their properties depends on the preparation processes of GQDs. Thus, certain types of preparation lead to certain defects, such as surface defect, edge defects, Stone-Wales defect. These structural defects are responsible for hindering GQDs to possess their regular shape that affects the morphological properties of GQDs. Thus, the optical and electrical properties get affected. The GQDs, which are synthesized via acidic methods are generally more vulnerable to defects compared to those synthesized using eco-friendly methods. Thereby, the aim of this review is to discuss the causes of structural defects. Moreover, it focuses on how they affect the properties of GQDs and to what extent they affect them. The processes of regulating defects have been elucidated so that more efficient applications can be designed using GQDs with controlled amounts of defects.

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Heterogeneous Photocatalysis for Wastewater Treatment

Pouran,

Habibi‐Yangjeh

2024

Catalysis for a Sustainable Environment

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Structural features regulated photoluminescence intensity and cell internalization of carbon and graphene quantum dots for bioimaging

Cited by 39 publications

References 85 publications

Development and application of naturally derived, cost‐effective CQDs with cancer targeting potential

Development and application of naturally derived, cost‐effective CQDs with cancer targeting potential

Structural defects in graphene quantum dots: A review

Heterogeneous Photocatalysis for Wastewater Treatment

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