Structural-functional changes in the proventriculus of poultry infected with transmissive viral proventriculitis

Kotsyumbas, G. I.; Zhyla, M. I.; Tyshkivska, A. M.; Kalinina, O. S.; Khmil, E. P.; Shkil, M. I.; Mysiv, O. V.; Tyshkivsky, M. Y.

doi:10.15421/022326

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…На сьогодні спостерігається чітка тенденція до зростання асортименту ветеринарних препаратів і кормових добавок на світовому та вітчизняному ринках. Значна зацікавленість підприємств, особливо тих, що вирощують птицю, є у препаратах, які володіють антибактеріальними властивостями, загальностимулюючою дією, не мають періоду каренції та в подальшому не спричиняють негативного впливу на продукцію тваринного походження (Berezovskyi, 2000;Havryliuk, 2007Havryliuk, , 2008Bushuieva, 2013;Kotsyumbas et al, 2023).…”

Section: вступunclassified

Evaluation morphofunctional state of broiler chickens body's under the applica-tion of various doses of Combiiod

Zhyla,

Pyatnychko,

Kotsyumbas

et al. 2024

SMLNUVMB

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One of the key and mandatory prerequisites for the creation and approbation of new veterinary preparations, both in the context of national legislation and the requirements of the International Community for Registration of Veterinary Medicines, is clinical studies in compliance with the provisions of “Good clinical practice” (GCP). This primarily concerns medicines with a new substance, pharmacology, and efficiency, which have not yet been studied. The technology of growing poultry requires the use of veterinary drugs not only for the prevention of infectious diseases but also for the improvement of metabolic functions and correction of the body’s resistance. One of the priority tasks is to ensure the complete work of the digestive system since it depends on the body's absorption of the nutrients required for the growth of poultry. Among poultry farms, there is considerable interest in drugs with antibacterial, general stimulating action, and coccidiostatics, especially those that do not have an elimination period. The company “Brovafarma” LLC has developed a new form of drug based on Povidone-iodine and sodium selenite for oral use of poultry for the treatment and prevention of diseases caused by bacteria, viruses, myxomycetes, protozoa organisms sensitive to iodine, and for metabolic disorders. That is why the purpose of our experimental studies was to study the safety of a new veterinary drug “Combiiod”, a “solution for oral use”, for healthy broiler chickens. According to the results of the study, it was found that the feeding of the drug “Combiiod” chickens-broiler at a therapeutic dose (0.2 ml per 1 liter of water) and in 5 multiple therapeutic doses (1.0 ml per 1 liter of water) within 5 days for two courses with weekly interval was well tolerated by the experimental poultry, did not cause death and violation of the morphofunctional state of broiler chickens bodies. In the blood of broiler chickens, which received the drug “Combiiod” at the therapeutic dose, most studied morphological and biochemical indicators were within the physiological values for this type of poultry. They did not differ significantly from the indicators of the control group. In the serum of poultry, which used 5 multiple therapeutic doses, a significant decrease in the content of erythrocytes, hemoglobin, and uric acid and an increase in the activity of alanine aminotransferase (ALT), alkaline phosphatase (ALP), and the content of bile acids were revealed. Analyzing the coefficients of individual internal organs and mass of broiler chickens, no significant difference in indicators between experimental and control groups has been noted. Pathomorphological examination has not established a violation of the morphofunctional state of broiler chickens ’ bodies, which received a therapeutic dose. Histological changes in the structure of the kidneys, liver, and heart, which were reversed, were found in the poultry that received 5 multiple therapeutic doses of the drug.

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Section: вступunclassified

Evaluation morphofunctional state of broiler chickens body's under the applica-tion of various doses of Combiiod

Zhyla,

Pyatnychko,

Kotsyumbas

et al. 2024

SMLNUVMB

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“…Keywords: BROILER CHICKENS, PASTEURELLOSIS, SUPERPYRIN, CLINICAL TRIALS, HEMATOLOGICAL, BIOCHEMICAL PARAMETERS OF BLOOD Сучасне птахівництво -динамічна галузь тваринництва, яка займає важливе місце в забезпеченні населення високоякісними дієтичними продуктами харчування та характеризується швидкими темпами відтворення поголів'я. Проте, у зв'язку з інтенсивним веденням галузі, птиця стає все більш чутливою до захворювань як вірусної, так і бактеріальної етіології (Mazurkiewicz & Wieliczko, 2019;Kotsyumbas et al, 2023). Серед бактеріальних захворювань, пастерельоз птиці (холера, геморагічна септицемія), може досить швидко розповсюджуватися поміж поголів'ям різного виду птиці та спричиняти серйозні втрати для птахогосподаств.…”

Section: Efficiency Of the Drug Superpyrin In The Complex Application...unclassified

Efficiency of the Drug Superpyrin in the Complex Application in the Treatment of Broiler Chickens

Kotsyumbas,

Pyatnychko,

Stetsko

et al. 2024

SCIVP

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The article presents the results of the study of the efficiency and safety of the drug Superpyrin, a powder for oral use, as a means of symptomatic therapy in the treatment of acute respiratory infections in broiler chickens. The active substances of the drug are acetylsalicylic, ascorbic and citric acids. The experiment was conducted on broiler chickens with clinical signs of bacterial disease – pasteurellosis. The diagnosis was made on the basis of clinical signs of the disease, the results of pathological and anatomical autopsy of dead chickens and the results of bacteriological examination of pat-material. Experimental and control groups of broiler chickens received the antimicrobial drug Doxycycline hyclate at a dose of 20 mg per kg of body weight per day orally with drinking water for 5 consecutive days. In addition to antimicrobial therapy, chickens-broiler of the experimental group received the test drug Superpyrin orally with drinking water at a dose of 1 g per 1 liter of water for 3 days. From the beginning of the treatment to the 14th day, the clinical state of the poultry of both groups was monitored, namely, the presence of adverse reactions, negative phenomena and body weight gain. Before the treatment and on the 10th day after the last administration of the drug Superpyrin, morphological and biochemical parameters of the chickens’ blood were examined. Hematological studies were conducted according to generally accepted methods, and biochemical – with the help of a semi-automatic biochemical analyzer Humalyzer 3000, using test-kits from the company Human. The obtained results were processed statistically. The results of a clinical study showed that the drug Superpyrin, a powder for oral use, in the recommended dosage, is an effective means for symptomatic therapy in the treatment of acute respiratory poultry disease of bacterial etiology. In the experimental group of chickens, the poultry mortality decreased, the treatment efficiency increased and body weight gains increased. No adverse reactions were recorded in poultry of the experimental group during the administration of the Superpyrin.

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Structural-functional changes in the proventriculus of poultry infected with transmissive viral proventriculitis

Cited by 2 publications

References 22 publications

Evaluation morphofunctional state of broiler chickens body's under the applica-tion of various doses of Combiiod

Evaluation morphofunctional state of broiler chickens body's under the applica-tion of various doses of Combiiod

Efficiency of the Drug Superpyrin in the Complex Application in the Treatment of Broiler Chickens

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