“…The remaining 5 studies were clinical research ( 18 , 53 – 56 ), comprising randomized controlled trial ( 53 ) and retrospective cohort studies ( 18 , 54 – 56 ). 17 studies were conducted in the United States ( 28 , 30 , 34 , 35 , 38 , 42 , 45 , 49 , 50 , 56 ), 8 in China ( 19 , 23 – 26 , 31 , 48 ), 7 in Europe ( 20 – 22 , 29 , 36 , 37 , 41 ), 4 in Japan ( 39 , 40 , 46 , 47 ), 2 in India ( 32 , 51 ), and 1 across three countries, namely United States, Argentina, and Puerto Rico ( 53 ). A summary of the main characteristics of each individual study is outlined in Tables 1 , 2 .…”