2024
DOI: 10.1038/s41586-024-07458-1
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Structural insights into the cross-exon to cross-intron spliceosome switch

Zhenwei Zhang,
Vinay Kumar,
Olexandr Dybkov
et al.

Abstract: Early spliceosome assembly can occur through an intron-defined pathway, whereby U1 and U2 small nuclear ribonucleoprotein particles (snRNPs) assemble across the intron1. Alternatively, it can occur through an exon-defined pathway2–5, whereby U2 binds the branch site located upstream of the defined exon and U1 snRNP interacts with the 5′ splice site located directly downstream of it. The U4/U6.U5 tri-snRNP subsequently binds to produce a cross-intron (CI) or cross-exon (CE) pre-B complex, which is then converte… Show more

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Cited by 7 publications
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