2021
DOI: 10.1107/s205979832100509x
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Structural insights into the interaction of papain-like protease 2 from the alphacoronavirus porcine epidemic diarrhea virus and ubiquitin

Abstract: Porcine epidemic diarrhea is a devastating porcine disease that is caused by the alphacoronavirus porcine epidemic diarrhea virus (PEDV). Like other members of the Coronaviridae family, PEDV encodes a multifunctional papain-like protease 2 (PLP2) that has the ability to process the coronavirus viral polyprotein to aid in RNA replication and antagonize the host innate immune response through cleavage of the regulatory proteins ubiquitin (Ub) and/or interferon-stimulated gene product 15 (ISG15) (deubiquitination… Show more

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Cited by 7 publications
(7 citation statements)
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“…[35] Preferences for isopeptidase over peptidase activity, [36] polyubiquitin chains over ISG15 or monoubiquitin, [37] and K48 over K63 ubiquitin linkages [38] also vary between viral lineages. [39,40] The distantly related foot-and-mouth disease virus (FMDV) leader protease even has irreversible deISGylating activity by leaving ISG15's C-terminal diglycine on its target lysine. [41] It is fair to assume, however, that cleavages predicted by all three sets of models can occur in many infections no matter viral lineage.…”
Section: Resultsmentioning
confidence: 99%
“…[35] Preferences for isopeptidase over peptidase activity, [36] polyubiquitin chains over ISG15 or monoubiquitin, [37] and K48 over K63 ubiquitin linkages [38] also vary between viral lineages. [39,40] The distantly related foot-and-mouth disease virus (FMDV) leader protease even has irreversible deISGylating activity by leaving ISG15's C-terminal diglycine on its target lysine. [41] It is fair to assume, however, that cleavages predicted by all three sets of models can occur in many infections no matter viral lineage.…”
Section: Resultsmentioning
confidence: 99%
“…The PL pro of the coronavirus in Nidovirales proteases, in addition to 3CL pro , have multiple cleavage sites on the viral polyprotein and act as deubiquitinases (DUBs) [ 55 , 56 , 57 ]. HCoV-OC43, HCoV-HKU1, HCoV-229E, HCoV-NL63, and CCoV-HuPn-2018 express two PL pro (PLP1 and PLP2) [ 58 ]. PLP2 has the same function as PL pro in other coronaviruses [ 55 , 56 , 57 ].…”
Section: Resultsmentioning
confidence: 99%
“…In addition, other researchers revealed the enzyme catalytic center of several coronavirus replicative enzymes. The enzyme catalytic centers of nsp3 are C1729, H1888, D1901, and W1730 ( Durie et al, 2021 ). Residues H41 and C144 are key amino acids of the activity of nsp5 ( Wang D et al, 2016 ).…”
Section: Discussionmentioning
confidence: 99%