A pressure vessel is a container that holds gases or liquids at a pressure significantly different from the ambient pressure. The nozzles were essential for inlet and outlet of liquid. A pressure vessel analysis is critical for its proper operation. In the present work, aspects have been considered regarding position and orientation of nozzles according to stress and deformation obtained. The whole objective is to use FEA simulation, and determine the best design solution. Two different type of nozzles viz. radial and tangential were incorporated. Different number of nozzles and different inclination angle of nozzle were also incorporated to study the effect of nozzle geometry. However, design of pressure vessels is based on solvent extraction process. It is observed that radial nozzle induced higher stress values as compared to tangential nozzle. However, as inclination angle increases, maximum stress values are increasing for pressure vessel with tangential nozzle as compared to radial nozzle.