Structural investigation and steric stabilisation of Guerbet glycolipid-based cubosomes and hexosomes using triblock polyethylene oxide-polypropylene oxide-polyethylene oxide copolymers

Zahid, N. Idayu; Salim, Malinda; Liew, Chia Yen; Boyd, Ben J.; Hashim, Roslan

doi:10.1016/j.colsurfa.2022.129212

Cited by 6 publications

(4 citation statements)

References 62 publications

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“…Similarly, it was reported that the morphology of galactose–oleic hexosomes was maintained upon dispersion with F127 . Meanwhile, owing to the self-assembling properties of the nonionic triblock copolymers, an increase in negative curvature was reported for Guerbet glycolipid-based LLCNs which occurred even in systems containing low concentrations of Pluronics L64 and F68, i.e., nonionic surfactants having shorter chain lengths of PPO . Further, the internal hexagonal (H 2 ) conformation of SPC/citrem was not altered by Gem and TQ coencapsulation in predetermined molar concentrations.…”

Section: Discussionmentioning

confidence: 76%

“…56 Meanwhile, owing to the selfassembling properties of the nonionic triblock copolymers, an increase in negative curvature was reported for Guerbet glycolipid-based LLCNs which occurred even in systems containing low concentrations of Pluronics L64 and F68, i.e., nonionic surfactants having shorter chain lengths of PPO. 57 Further, the internal hexagonal (H 2 ) conformation of SPC/ citrem was not altered by Gem and TQ coencapsulation in predetermined molar concentrations. However, variations from the previously reported structure pertaining to SPC/citrem LLCNs (SPC/citrem in 1:1 ratio) may be attributed to batchto-batch variability in composition, as lipid/emulsifier composition has been known to influence the internal structure and hydrodynamic particle size.…”

Section: Discussionmentioning

confidence: 93%

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Coencapsulation of Gemcitabine and Thymoquinone in Citrem–Phosphatidylcholine Hexosome Nanocarriers Improves In Vitro Cellular Uptake in Breast Cancer Cells

Loo,

Zahid,

Madheswaran

et al. 2023

Mol. Pharmaceutics

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Lyotropic liquid crystalline nanoassemblies (LLCNs) are internally self-assembled (ISA)-somes formed by amphiphilic molecules in a mixture comprising a lipid, stabilizer, and/or surfactant and aqueous media/dispersant. LLCNs are unique nanoassemblies with versatile applications in a wide range of biomedical functions. However, they comprise a nanosystem that is yet to be fully explored for targeted systemic treatment of breast cancer. In this study, LLCNs proposed for gemcitabine and thymoquinone (Gem-TQ) co-delivery were prepared from soy phosphatidylcholine (SPC), phytantriol (PHYT), or glycerol monostearate (MYVR) in optimized ratios containing a component of citric and fatty acid ester-based emulsifier (Grinsted citrem) or a triblock copolymer, Pluronic F127 (F127). Hydrodynamic particle sizes determined were below 400 nm (ranged between 96 and 365 nm), and the series of nanoformulations displayed negative surface charge. Nonlamellar phases identified by small-angle X-ray scattering (SAXS) profiles comprise the hexagonal, cubic, and micellar phases. In addition, high entrapment efficiency that accounted for 98.3 ± 0.1% of Gem and 99.5 ± 0.1% of TQ encapsulated was demonstrated by the coloaded nanocarrier system, SPC/citrem/Gem-TQ hexosomes. Low cytotoxicity of SPC-citrem hexosomes was demonstrated in MCF10A cells consistent with hemo- and biocompatibility observed in zebrafish (Danio rerio) embryos for up to 96 h postfertilization (hpf). SPC/citrem/Gem-TQ hexosomes demonstrated IC50 of 24.7 ± 4.2 μM in MCF7 breast cancer cells following a 24 h treatment period with the moderately synergistic interaction between Gem and TQ retained (CI = 0.84). Taken together, biocompatible SPC/citrem/Gem-TQ hexosomes can be further developed as a multifunctional therapeutic nanodelivery approach, plausible for targeting breast cancer cells by incorporation of targeting ligands.

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 93%

Coencapsulation of Gemcitabine and Thymoquinone in Citrem–Phosphatidylcholine Hexosome Nanocarriers Improves In Vitro Cellular Uptake in Breast Cancer Cells

Loo,

Zahid,

Madheswaran

et al. 2023

Mol. Pharmaceutics

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“…In addition, it provides detailed structural analysis and physical information of the sample including the dimensions, lattice type, and surface-to-volume ratio, with the size ranging from 1 to 100 nm [ 61 ]. Moreover, the absolute position of the Bragg peaks enables the calculation of the average lattice parameter,

, of the matrices, from the corresponding interplanar spacing,

(

, where

refers to the scattering vector), using the proper scattering law for the phase structure [ 64 ]. Comparing the obtained Bragg peaks with databases allows the determination of the internal structure of nanoparticles since every phase has a typical peak ratio.…”

Section: Characterization Techniquesmentioning

confidence: 99%

“…using the proper scattering law for the phase structure [64]. Comparing the obtained Bragg peaks with databases allows the determination of the internal structure of nanoparticles since every phase has a typical peak ratio.…”

Section: Characterization Techniquesmentioning

confidence: 99%

Recent Advances in the Development of Liquid Crystalline Nanoparticles as Drug Delivery Systems

Leu,

Teoh,

Ling

et al. 2023

Pharmaceutics

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Due to their distinctive structural features, lyotropic nonlamellar liquid crystalline nanoparticles (LCNPs), such as cubosomes and hexosomes, are considered effective drug delivery systems. Cubosomes have a lipid bilayer that makes a membrane lattice with two water channels that are intertwined. Hexosomes are inverse hexagonal phases made of an infinite number of hexagonal lattices that are tightly connected with water channels. These nanostructures are often stabilized by surfactants. The structure’s membrane has a much larger surface area than that of other lipid nanoparticles, which makes it possible to load therapeutic molecules. In addition, the composition of mesophases can be modified by pore diameters, thus influencing drug release. Much research has been conducted in recent years to improve their preparation and characterization, as well as to control drug release and improve the efficacy of loaded bioactive chemicals. This article reviews current advances in LCNP technology that permit their application, as well as design ideas for revolutionary biomedical applications. Furthermore, we have provided a summary of the application of LCNPs based on the administration routes, including the pharmacokinetic modulation property.

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Performance of alkyl β-D-maltosides in molecular self-assembly and formation of oil-in-water nanoemulsions as drug delivery systems

Nordin

Ahmad

Salim

et al. 2023

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Structural investigation and steric stabilisation of Guerbet glycolipid-based cubosomes and hexosomes using triblock polyethylene oxide-polypropylene oxide-polyethylene oxide copolymers

Cited by 6 publications

References 62 publications

Coencapsulation of Gemcitabine and Thymoquinone in Citrem–Phosphatidylcholine Hexosome Nanocarriers Improves In Vitro Cellular Uptake in Breast Cancer Cells

Coencapsulation of Gemcitabine and Thymoquinone in Citrem–Phosphatidylcholine Hexosome Nanocarriers Improves In Vitro Cellular Uptake in Breast Cancer Cells

Recent Advances in the Development of Liquid Crystalline Nanoparticles as Drug Delivery Systems

Performance of alkyl β-D-maltosides in molecular self-assembly and formation of oil-in-water nanoemulsions as drug delivery systems

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