Structural investigation of a novel rhamnoglucogalactan isolated from the fruiting bodies of the fungus Hericium erinaceus

Jia, Lian-meng; Liu, Liu; Dong, Qun; Fang, Jing

doi:10.1016/j.carres.2004.07.027

Cited by 50 publications

(29 citation statements)

References 9 publications

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“…In this field, a β-(1→3)-linked D-glucan with single unit glucosyl branches attached at O-6 of every third backbone residue has been isolated from Hericium erinaceus [51]. Heteropolysaccharides have been also isolated from this mushroom; thus, an α-(1→6)-linked D-galactopyranosyl with rhamnose and glucose branches at O-2 has been described [52]. A linear water-insoluble β-(1→3)-D-glucan have been extracted from the fruit body of Ganoderma lucidum [53], as well as a water-soluble (1→6)-linked glucan with (1→4) branches at O-4 [54], or a heteropolysaccharide composed of 1,4-linked α-D-glucopyranosyl and 1,6-linked β-D-galactopyranosyl residues with branches at O-6 of glucose and O-2 of galactose residues [55].…”

Section: Structural Features Of Polysaccharides Occurring In Mushroomsmentioning

confidence: 99%

Structural Features and Healthy Properties of Polysaccharides Occurring in Mushrooms

2012

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Abstract:Polysaccharides from mushrooms have attracted a great deal of attention due to the many healthy benefits they have demonstrated, such as immunomodulation, anticancer activity, prevention and treatment of cardiovascular diseases, antiviral and antimicrobial effects, among others. Isolation and purification of polysaccharides commonly involve several steps, and different techniques are actually available in order to increase extraction yield and purity. Studies have demonstrated that the molecular structure and arrangement significantly influence the biological activity; therefore, there is a wide range of analytical techniques for the elucidation of chemical structures. Different polysaccharides have been isolated from mushrooms, most of them consisting of β-linked glucans, such as lentinan from Lentinus edodes, pleuran from Pleurotus species, schizophyllan from Schizophyllum commune, calocyban from Calocybe indica, or ganoderan and ganopoly from Ganoderma lucidum. This article reviews the main methods of polysaccharide isolation and structural characterization, as well as some of the most important polysaccharides isolated from mushrooms and the healthy benefits they provide.

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Section: Structural Features Of Polysaccharides Occurring In Mushroomsmentioning

confidence: 99%

Structural Features and Healthy Properties of Polysaccharides Occurring in Mushrooms

2012

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“…The constituents of H. erinaceum have been previously investigated and shown to contain aromatic compounds, [2][3][4][5] fatty acids, 6) sterols 7) and polysaccharides. 8) Some aromatic compounds, including hericenone A (3), were found to have significant cytotoxicity against HeLa cells 2) and stimulating activity of the synthesis of the nerve growth factor. 3) In a continuation of our investigation of chemical constituents from mushrooms, we describe here the isolation and structural elucidation of two new aromatic compounds, erinacerins A (1) and B (2), together with a known compound (3) from the fruiting bodies of H. erinaceum.…”

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Two New Aromatic Compounds from Hericium erinaceum (BULL.: FR.) PERS.

2005

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“…Many of these studies have focused on the activation of NK cells and demonstrated positive results [14,15] . Furthermore, polysaccharides found in various mushrooms have recently attracted attention due to their NK cell-related immune-activating properties [16][17][18][19] . Hericium erinaceum is a widely cultivated edible mushroom and has been used in several Asian countries to treat various human diseases.…”

Section: Introductionmentioning

confidence: 99%

Soluble components of Hericium erinaceum induce NK cell activation via production of interleukin-12 in mice splenocytes

Yim

Shin

Son

et al. 2007

Acta Pharmacologica Sinica

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Aim: To investigate the immunoregulatory functions of water extracts of Hericium erinaceum (WEHE) focusing on natural killer (NK) cell-based anticancer activities. Methods: Mouse splenocytes or purely isolated NK cells were stimulated with 1-100 mg/L WEHE for 24 h followed by co-culture with 51 Cr-labled Yac-1 cells for 4 h, then NK cell-derived cytolytic activity was measured using a radio-release assay. Neutralizing antibodies against mouse interleukin-12 (IL-12) were added into the WEHE-stimulated splenocytes, thereafter, cytotoxicity was measured to examine the involvement of IL-12. RT-PCR and ELISA analyses were performed to confirm the induction of transcription and the translation of IL-12 and interferongamma (IFN-gamma) in the WEHE-treated splenocytes. Results: WEHE enhanced the cytolytic activity of total splenocytes towards Yac-1 cells in a dose-dependent manner. However, this activation was not observed when the NK cells isolated from the splenocytes were treated with WEHE. Furthermore, the treatment with antibodies against IL-12 abolished the effect of WEHE on splenocyte-derived cytolytic activity. RT-PCR and ELISA analyses showed the induction of IL-12 and IFN-gamma in the WEHE-treated splenocytes. Conclusion: WEHE indirectly activates the cytolytic ability of NK cells via the induction of IL-12 in total splenocytes, and possibly via other immuno-mediators or cellular components.

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Structural investigation of a novel rhamnoglucogalactan isolated from the fruiting bodies of the fungus Hericium erinaceus

Cited by 50 publications

References 9 publications

Structural Features and Healthy Properties of Polysaccharides Occurring in Mushrooms

Structural Features and Healthy Properties of Polysaccharides Occurring in Mushrooms

Two New Aromatic Compounds from Hericium erinaceum (BULL.: FR.) PERS.

Soluble components of Hericium erinaceum induce NK cell activation via production of interleukin-12 in mice splenocytes

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