Structural-Mechanical and Biochemical Functions of Classical Cadherins at Cellular Junctions: A Review and Some Hypotheses

Tiwari, Prince; Mrigwani, Arpita; Kaur, Harpreet; Kaila, Pallavi; Kumar, Rajendra; Guptasarma, Purnananda

doi:10.1007/978-981-13-3065-0_9

Cited by 20 publications

(19 citation statements)

References 162 publications

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“…Cadherins are a superfamily of more than 100 Ca 2+ ‐dependent cell–cell adhesion molecules (Angst, Marcozzi, & Magee, 2001; Gul, Hulpiau, Saeys, & van Roy, 2017; Kemler, Ozawa, & Ringwald, 1989; Koch, Bozic, Pertz, & Engel, 1999; Nollet, Kools, & van Roy, 2000; Yagi & Takeichi, 2000). These transmembrane glycoproteins (Figure 3) have many important roles in cell–cell contact and cell signaling during tissue morphogenesis and also in the maintenance of tissue homeostasis (Gallin, 1998; Gumbiner, 1996; Leckband & Sivasankar, 2012; Maitre & Heisenberg, 2013; Mohamet, Hawkins, & Ward, 2011; Niessen, Leckband, & Yap, 2011; Takeichi, 1995, 1988; Tiwari et al 2018). Three classical cadherin groups that are named for their tissue distribution and function include epithelial cadherin (E‐cadherin), neural cadherin (N‐cadherin), and placental cadherin (P‐cadherin; Moore, Radice, Dominis, & Kemler, 1999).…”

Section: Families Of Adhesion Moleculesmentioning

confidence: 99%

Adhesion molecules in gamete transport, fertilization, early embryonic development, and implantation—role in establishing a pregnancy in cattle: A review

D’Occhio

Campanile

Zicarelli

et al. 2020

Molecular Reproduction Devel

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Cell–cell adhesion molecules have critically important roles in the early events of reproduction including gamete transport, sperm–oocyte interaction, embryonic development, and implantation. Major adhesion molecules involved in reproduction include cadherins, integrins, and disintegrin and metalloprotease domain‐containing (ADAM) proteins. ADAMs on the surface of sperm adhere to integrins on the oocyte in the initial stages of sperm–oocyte interaction and fusion. Cadherins act in early embryos to organize the inner cell mass and trophectoderm. The trophoblast and uterine endometrial epithelium variously express cadherins, integrins, trophinin, and selectin, which achieve apposition and attachment between the elongating conceptus and uterine epithelium before implantation. An overview of the major cell–cell adhesion molecules is presented and this is followed by examples of how adhesion molecules help shape early reproductive events. The argument is made that a deeper understanding of adhesion molecules and reproduction will inform new strategies that improve embryo survival and increase the efficiency of natural mating and assisted breeding in cattle.

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Section: Families Of Adhesion Moleculesmentioning

confidence: 99%

Adhesion molecules in gamete transport, fertilization, early embryonic development, and implantation—role in establishing a pregnancy in cattle: A review

D’Occhio

Campanile

Zicarelli

et al. 2020

Molecular Reproduction Devel

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“…The classical cadherin family is comprised of various proteins, including E-cadherin, Ncadherin and P-cadherin, all of which are required for normal cell-cell adhesion. A number of studies has shown that deregulation and abnormal expression of classical cadherins may result in aberrant adherent junctions, eventually contributing to the initiation and progression of malignancies [27]. More importantly, cadherin switches (referred to as switches from E-cadherin to P-cadherin or E-cadherin to N-cadherin) have been regarded as key hallmarks of EMT [28] and to be involved in TGF-β signaling-induced EMT [29].…”

Section: Discussionmentioning

confidence: 99%

WNT1, a target of miR-34a, promotes cervical squamous cell carcinoma proliferation and invasion by induction of an E-P cadherin switch via the WNT/β-catenin pathway

Guo

et al. 2020

Cell Oncol.

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Purpose Persistent infection with high-risk human papillomavirus (HR-HPV) is thought to play a prominent role in the initiation and progression of almost all cases of cervical cancer. Previously, we and others found that microRNA 34a (miR-34a) may be regulated by HR-HPV E6 to contribute to the development of cervical cancer. Here, we aimed to identify the oncogenic potential and clinical significance of a known miR-34a target, WNT1, in cervical squamous cell carcinoma (SCC) development and to investigate the associated mechanisms underlying cervical SCC cell proliferation and invasion. Methods WNT1 and miR-34a expression levels were assessed in primary cervical lesions using immunohistochemistry and qRT-PCR, respectively. The cellular effects and the expression of its associated genes were examined in cervical SCC-derived Siha and Caski cells after siRNA-WNT1 (downregulation) or miR-34a mimic (upregulation) treatment. A cervical SCC xenograft mouse model was used to investigate the in vivo effects of miR-34a overexpression. HPV-16 E6/E7 expression was inhibited by gene promoter siRNA targeting, after which the levels of miR-34a and WNT1 were examined. Results WNT1 protein upregulation was found to be associated with a poor prognosis in cervical SCC patients. In vitro assays in Siha and Caski cells revealed that WNT1 downregulation decreased cell proliferation and invasion, inhibited WNT/β-catenin activation and affected the expression of E-cadherin and P-cadherin. MiR-34a upregulation resulted in decreased WNT1 expression. An inverse correlation between miR-34a and WNT1 expression was also observed in primary cervical SCC tissues. In addition, we found that MiR-34a could regulate an E-cadherin to P-cadherin switch (E-P cadherin switch) to inhibit cell proliferation and tumorigenesis in vitro and in vivo via inactivation of the WNT1/β-catenin pathway. Finally, we found that decreased HPV-16 E6/E7 expression resulted in miR-34a upregulation and WNT1 downregulation in Siha and Caski cells. Conclusions From our results we conclude that WNT1, as a target of miR-34a, can promote cervical SCC cell proliferation and invasion by induction of an E-P cadherin switch via the WNT1/β-catenin pathway. Our results may provide new options for the treatment of patients with cervical SCC.Keywords Cervical squamous cell carcinoma . miR-34a . WNT1 . E-cadherin . P-cadherin . Cadherin switch Electronic supplementary material The online version of this article (https://doi.

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“…However, in the present study, GPNMB mRNA expression in the urinary sediment modified the slope of eGFR in T1D patients across time, maybe reflecting a compensatory mechanism of tissue repairing as kidney disease progresses. CDH6 or kidney cadherin belongs to the cadherin superfamily of cell surface glycoproteins essential to tissue development and to cell-cell adhesion (37). In a transcriptional analysis of human kidney organoids derived from pluripotent stem cells, CDH6 mRNA was identified as highly expressed in immature glomerular epithelial cells and reactivated in injured podocytes in chronic kidney diseases, including DKD.…”

Section: Discussionmentioning

confidence: 99%

Urinary Sediment Transcriptomic and Longitudinal Data to Investigate Renal Function Decline in Type 1 Diabetes

et al. 2020

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Structural-Mechanical and Biochemical Functions of Classical Cadherins at Cellular Junctions: A Review and Some Hypotheses

Cited by 20 publications

References 162 publications

Adhesion molecules in gamete transport, fertilization, early embryonic development, and implantation—role in establishing a pregnancy in cattle: A review

Adhesion molecules in gamete transport, fertilization, early embryonic development, and implantation—role in establishing a pregnancy in cattle: A review

WNT1, a target of miR-34a, promotes cervical squamous cell carcinoma proliferation and invasion by induction of an E-P cadherin switch via the WNT/β-catenin pathway

Urinary Sediment Transcriptomic and Longitudinal Data to Investigate Renal Function Decline in Type 1 Diabetes

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