2022
DOI: 10.3892/wasj.2022.175
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Structural models for the design of novel antiviral agents against Spondweni virus helicase

Abstract: Spondweni virus (SPONV), a possible emerging virus, is a member of the Flaviviridae virus family, of the genus Flavivirus and belongs to a serogroup with the Zika virus. The latest epidemic of Zika fever, which broke out in the Western Hemisphere, warns about the risk of the corresponding urban epidemic potential of SPONV and calls for the design of anti-SPONV therapies. Previous studies have demonstrated that viral RNA helicases represent promising pharmacological targets for antiviral drugs/inhibitors, as th… Show more

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