Structural modification of poly(2-hydroxyethyl methacrylate)–silica hybrids utilizing 3-methacryloxypropyltrimethoxysilane

Costa, Ricardo O.R.; Vasconcelos, Wander L.

doi:10.1016/s0022-3093(02)01008-6

Cited by 40 publications

(22 citation statements)

References 14 publications

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“…The general increase in T g and the gradual shift to high temperatures of its associated mechanical relaxation (Fig. 3.12, p. 58) with increasing silica contents has been observed previously by other authors [109] , and points to the restriction of polymer chains mobility as they become more intertwined with the rigid silica network, resulting in a reinforcing effect. The compressive elastic modulus of the nanocomposites (Fig.…”

Section: Characterization Of P(ema-co-hea)/sio 2 Nanocompositessupporting

confidence: 77%

“…Silica reduces the thermal stability of the nanocomposites, thus shifting the thermogravimetric curves to lower temperatures, but not reaching the PEMA decomposition profile, which starts to decompose at 210ºC. This loss of thermal stability of the silica hybrids was also observed by Costa et al [109] in PHEMA/SiO 2 composites, who explained it on the basis of a decrease in hydrogen-bonding among copolymer chains promoted by the presence of silica. Other authors [89,111] observed the opposite effect and attributed it to a good homogeneity due to nanoscale mixing and to relatively strong heterogeneous hydrogen bonds tethering silica and polymer chains.…”

Section: Characterization Of P(ema-co-hea)/sio 2 Nanocompositesmentioning

confidence: 54%

“…Polymers that have been hybridized with this purpose include poly(ε-caprolactone) [103][104][105][106] , poly(2-hydroxyethyl methacrylate) [89][90][91][107][108][109][110][111][112] , poly(2-hydroxyethyl acrylate) [113] , poly(methyl methacrylate) [92,114] , poly(butyl acrylate) [115] , poly(ethylene oxide) [116,117] , poly(ethylene oxide-co-epichlorhydrin) [118] , polyimide [119] , polyamide 6,6 [120] , poly(vinyl acetate) [121] , or poly(vinyl alcohol) [122] .…”

Section: Polymer/silica Nanohybrids Obtained By Sol-gel Processmentioning

confidence: 99%

“…The resulting spectra after this substraction have been depicted in the 1400-600 cm -1 range in Figure 3.3. The peaks appearing at 1060-1100 and 800 cm -1 are attributed to the Si-O-Si asymmetric and symmetric stretching vibration, respectively, and the peak at 950 cm -1 is characteristic of the Si-OH stretching vibration of the silica phase [90,91,104,108,109,111,122,143] . Their intensities increase proportionally to the silica content.…”

Section: X-ray Diffraction (Xrd)mentioning

confidence: 99%

“…hybrids, the intensity of the peaks at 1060-1100 and 950 cm -1 attributed to Si-O-Si and Si-OH bonds of the silica phase, respectively [90,104,108,109,112,122,145] , decrease with the immersion time in SBF, until FTIR cannot detect the original surface. It occurs similarly with the rest of the hybrids.…”

Section: Fourier-transform Infrared Analysismentioning

confidence: 99%

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P(EMA-co-HEA)/SiO2 hybrid nanocomposites for guided dentin tissue regeneration: structure, characterization and bioactivity.

Vallés-Lluch¹

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Section: Characterization Of P(ema-co-hea)/sio 2 Nanocompositessupporting

confidence: 77%

Section: Characterization Of P(ema-co-hea)/sio 2 Nanocompositesmentioning

confidence: 54%

Section: Polymer/silica Nanohybrids Obtained By Sol-gel Processmentioning

confidence: 99%

Section: X-ray Diffraction (Xrd)mentioning

confidence: 99%

Section: Fourier-transform Infrared Analysismentioning

confidence: 99%

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P(EMA-co-HEA)/SiO2 hybrid nanocomposites for guided dentin tissue regeneration: structure, characterization and bioactivity.

Vallés-Lluch¹

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Preparation of silica‐filled poly(2‐hydroxymethyl methacrylate) nanocomposites cured by photoirradiation during the sol–gel process

Lin

Chen

et al. 2004

J of Applied Polymer Sci

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ABSTRACT:The sol-gel process was used to prepare a photosensitive inorganic-organic composite, silica/poly(2-hydroxymethyl methacrylate). Its nanoscale morphology was observed with field emission scanning electron microscopy at high magnifications (e.g., 160,000ϫ). The size of the particles in the nanocomposite synthesized under various preparation conditions fell in the range of 20 -50 nm. The effects of the pH, reactant composition, and solvent content in the reaction mixture on the thermal and mechanical properties of the nanocomposite were studied with thermogravimetric analysis, dynamic mechanical analysis, and thermomechanical analysis. The thermal stability of the synthesized nanocomposite could generally be improved by an increase in the molar ratio of the inorganic component, a reduction in the reaction pH, or an increase in the solvent content.

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Ten‐year follow‐up of a phase 2 study of dose‐intense paclitaxel with cisplatin and cyclophosphamide as initial therapy for poor‐prognosis, advanced‐stage epithelial ovarian cancer

Sarosy

Hussain

Seiden

et al. 2010

Cancer

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BACKGROUND:The objective of this study was to assess activity and toxicity in patients with newly diagnosed, advanced-stage epithelial ovarian cancer (EOC) who were receiving dose-intense paclitaxel, cyclophosphamide, cisplatin, and filgrastim delivered with a flexible dosing schedule. METHODS: Patients with stage III/IV EOC received cyclophosphamide 750 mg/m 2 , followed by a 24-hour infusion of paclitaxel 250 mg/m 2 and cisplatin 75 mg/m 2 on Day 2. Filgrastim began on Day 3 at 10 lg/kg daily for 9 days. Patients received 6 cycles of all drugs. Those who achieved a pathologic complete response or had microscopic residual disease at the conclusion of 6 cycles of therapy received an additional 2 to 4 cycles of paclitaxel with cyclophosphamide. Patients who had an objective response continued on cyclophosphamide and paclitaxel. RESULTS: Sixty-two patients were enrolled. Thirty-two of 62 patients had stage IIIC disease, and 26 of 62 patients had stage IV disease. According to an intent-to-treat analysis, 55 patients (89%) experienced a clinical complete remission. At a median potential follow-up of 11.4 years, the median progression-free survival was 18.9 months, and the median survival was 5.4 years. The most serious toxicity was grade 3/4 neutropenic fever (35%). Although all participants developed peripheral neuropathy, improvement in neuropathic symptoms began with the decrease or cessation of paclitaxel. CONCLUSIONS: The studied regimen yielded a high response rate and encouraging overall survival. The current data and those reported by the Japanese Gynecologic Oncology Group suggest that further study is warranted of dose-dense or dose-intense paclitaxel regimens in women with newly diagnosed, advanced-stage EOC.

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Structural modification of poly(2-hydroxyethyl methacrylate)–silica hybrids utilizing 3-methacryloxypropyltrimethoxysilane

Cited by 40 publications

References 14 publications

P(EMA-co-HEA)/SiO2 hybrid nanocomposites for guided dentin tissue regeneration: structure, characterization and bioactivity.

P(EMA-co-HEA)/SiO2 hybrid nanocomposites for guided dentin tissue regeneration: structure, characterization and bioactivity.

Preparation of silica‐filled poly(2‐hydroxymethyl methacrylate) nanocomposites cured by photoirradiation during the sol–gel process

Ten‐year follow‐up of a phase 2 study of dose‐intense paclitaxel with cisplatin and cyclophosphamide as initial therapy for poor‐prognosis, advanced‐stage epithelial ovarian cancer

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