“…G4 structures have gained profound attention as they harbor various biological functions. Putative G4 forming sequences are present in the telomeric region, the promoter region of various protooncogenes, and the untranslated region of mRNAs and are observed in the immunoglobulin switch regions. , Due to their dynamic nature, these structures can sample parallel, hybrid (3 + 1), and antiparallel topologies depending on the type and size of the loop, glycosyl dihedral angle, nucleotide chain length, and nature of metal ions. , The human telomeric G4 sequence exhibits polymorphism across parallel, hybrid (3 + 1), and antiparallel topologies modulated by metal ions and molecular crowding agents . On the other hand, putative G4 forming sequences at the promoter regions ( c-MYC , c-KIT , BCL-2 , VEGF , HIF-1 α, PDGF , RET, etc.)…”