Structural Neuroimaging of Hippocampus and Amygdala Subregions in Posttraumatic Stress Disorder: A Scoping Review

Ben‐Zion, Ziv; Korem, Nachshon; Fine, Naomi B.; Katz, Sophia; Siddhanta, Megha; Funaro, Melissa; Duek, Or; Spiller, Tobias R.; Danböck, Sarah K.; Levy, Ifat; Harpaz‐Rotem, Ilan

doi:10.1016/j.bpsgos.2023.07.001

Cited by 6 publications

(1 citation statement)

References 141 publications

(302 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The conflicting reports of increased amygdala activity and reduced volumetric data is consistent with previous findings in PTSD ( 33 ), and may be partly explained by a lack of distinction between regional changes in specific amygdala nuclei and those of the whole amygdala ( 21 ). A recent scoping review of structural neuroimaging studies examining hippocampus and amygdala subregions in adults with PTSD reported that only 5 of the 21 eligible studies focused on volume changes in the amygdala, highlighting the anatomical complexity and methodological challenges of establishing structural changes in this brain region ( 34 ). Functional neuroimaging, alternatively, may hold greater promise in understanding the role of the amygdala in PTSD pathophysiology ( 35 ).…”

Section: Observationsmentioning

confidence: 99%

Post-traumatic stress disorder: the role of the amygdala and potential therapeutic interventions – a review

Davis,

Hamner

2024

Front. Psychiatry

View full text Add to dashboard Cite

IntroductionPost-traumatic stress disorder (PTSD) is a psychiatric disorder triggered by exposure to a life-threatening or sexually violent traumatic event, and is characterized by symptoms involving intrusive re-experiencing, persistent avoidance of associated stimuli, emotional and cognitive disturbances, and hyperarousal for long periods after the trauma has occurred. These debilitating symptoms induce occupational and social impairments that contribute to a significant clinical burden for PTSD patients, and substantial socioeconomic costs, reaching approximately $20,000 dollars per individual with PTSD each year in the US. Despite increased translational research focus in the field of PTSD, the development of novel, effective pharmacotherapies for its treatment remains an important unmet clinical need.ObservationsIn this review, we summarize the evidence implicating dysfunctional activity of the amygdala in the pathophysiology of PTSD. We identify the transient receptor potential canonical (TRPC) ion channels as promising drug targets given their distribution in the amygdala, and evidence from animal studies demonstrating their role in fear response modulation. We discuss the evidence-based pharmacotherapy and psychotherapy treatment approaches for PTSD.DiscussionIn view of the prevalence and economic burden associated with PTSD, further investigation is warranted into novel treatment approaches based on our knowledge of the involvement of brain circuitry and the role of the amygdala in PTSD, as well as the potential added value of combined pharmacotherapy and psychotherapy to better manage PTSD symptoms.

show abstract

Section: Observationsmentioning

confidence: 99%

Post-traumatic stress disorder: the role of the amygdala and potential therapeutic interventions – a review

Davis,

Hamner

2024

Front. Psychiatry

View full text Add to dashboard Cite

show abstract

Neuroimaging-based variability in subtyping biomarkers for psychiatric heterogeneity

Wen,

Hammoud,

Siegel

et al. 2024

Mol Psychiatry

View full text Add to dashboard Cite

Functional Domains of Substance Use and their Implications to Trauma: A Systematic Review of Neuroimaging Studies

Hinojosa,

Sitar,

Zhao

et al. 2024

Chronic Stress

View full text Add to dashboard Cite

Substance use disorder (SUD) is a significant health problem, and trauma exposure is a known risk factor for the escalation of substance use. However, the shared neural mechanisms through which trauma is associated with substance use are still unknown. Therefore, we systematically review neuroimaging studies focusing on three domains that may contribute to the overlapping mechanisms of SUD and trauma—reward salience, negative emotionality, and inhibition. Using PRISMA guidelines, we identified 45 studies utilizing tasks measuring these domains in alcohol, tobacco, and cannabis use groups. Greater reward, lesser regulation of inhibitory processes, and mixed findings of negative emotionality processes in individuals who use substances versus controls were found. Specifically, greater orbitofrontal cortex, ventral tegmental area, striatum, amygdala, and hippocampal activation was found in response to reward-related tasks, and reduced activation was found in the inferior frontal gyrus and hippocampus in response to inhibition-related tasks. Importantly, no studies in trauma-exposed individuals met our review criteria. Future studies examining the role of trauma-related factors are needed, and more studies should explore inhibition- and negative-emotionality domains in individuals who use substances to uncover clinically significant alterations in these domains that place an individual at greater risk for developing a SUD.

show abstract

Structural Neuroimaging of Hippocampus and Amygdala Subregions in Posttraumatic Stress Disorder: A Scoping Review

Cited by 6 publications

References 141 publications

Post-traumatic stress disorder: the role of the amygdala and potential therapeutic interventions – a review

Post-traumatic stress disorder: the role of the amygdala and potential therapeutic interventions – a review

Neuroimaging-based variability in subtyping biomarkers for psychiatric heterogeneity

Functional Domains of Substance Use and their Implications to Trauma: A Systematic Review of Neuroimaging Studies

Contact Info

Product

Resources

About