Structural, optical characteristics and Anti-Cancer effect of Cd0.99Ni0.01O nanoparticles on human neuroblastoma and cervical cancer cell lines

Shalaby, M.S.; Kodous, Ahmad S.; Yousif, N.M.

doi:10.1016/j.inoche.2022.109583

Cited by 5 publications

(2 citation statements)

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“…To establish control, a solution comprising isopropanol and hydrochloric acid was employed, and its measurement was deducted from the recorded values of the other samples. The Equation (1) was employed to calculate the percentage of cell viability ( 25 – 28 ):…”

Section: Methodsmentioning

confidence: 99%

Hesperidin - loaded PVA/alginate hydrogel: targeting NFκB/iNOS/COX-2/TNF-α inflammatory signaling pathway

Kodous,

Abdel-Maksoud,

El-Tayeb

et al. 2024

Front. Immunol.

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IntroductionSkin injuries represent a prevalent form of physical trauma, necessitating effective therapeutic strategies to expedite the wound healing process. Hesperidin, a bioflavonoid naturally occurring in citrus fruits, exhibits a range of pharmacological attributes, including antimicrobial, antioxidant, anti-inflammatory, anticoagulant, and analgesic properties. The main objective of the study was to formulate a hydrogel with the intention of addressing skin conditions, particularly wound healing.MethodsThis research introduces a methodology for the fabrication of a membrane composed of a Polyvinyl alcohol - Sodium Alginate (PVA/A) blend, along with the inclusion of an anti-inflammatory agent, Hesperidin (H), which exhibits promising wound healing capabilities. A uniform layer of a homogeneous solution comprising PVA/A was cast. The process of crosslinking and the enhancement of hydrogel characteristics were achieved through the application of gamma irradiation at a dosage of 30 kGy. The membrane was immersed in a Hesperidin (H) solution, facilitating the permeation and absorption of the drug. The resultant system is designed to deliver H in a controlled and sustained manner, which is crucial for promoting efficient wound healing. The obtained PVA/AH hydrogel was evaluated for cytotoxicity, antioxidant and free radical scavenging activities, anti-inflammatory and membrane stability effect. In addition, its action on oxidative stress, and inflammatory markers was evaluated on BJ-1 human normal skin cell line.Results and DiscussionWe determined the effect of radical scavenging activity PVA/A (49 %) and PVA/AH (87%), the inhibition of Human red blood cell membrane hemolysis by PVA/AH (81.97 and 84.34 %), hypotonicity (83.68 and 76.48 %) and protein denaturation (83.17 and 85.8 %) as compared to 250 μg/ml diclofenac (Dic.) and aspirin (Asp.), respectively. Furthermore, gene expression analysis revealed an increased expression of genes associated with anti-oxidant and anti-inflammatory properties and downregulated TNFα, NFκB, iNOS, and COX2 by 67, 52, 58 and 60%, respectively, by PVA/AH hydrogel compared to LPS-stimulated BJ-1 cells. The advantages associated with Hesperidin can be ascribed to its antioxidant and anti-inflammatory attributes. The incorporation of Hesperidin into hydrogels offers promise for the development of a novel, secure, and efficient strategy for wound healing. This innovative approach holds potential as a solution for wound healing, capitalizing on the collaborative qualities of PVA/AH and gamma irradiation, which can be combined to establish a drug delivery platform for Hesperidin.

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Section: Methodsmentioning

confidence: 99%

Hesperidin - loaded PVA/alginate hydrogel: targeting NFκB/iNOS/COX-2/TNF-α inflammatory signaling pathway

Kodous,

Abdel-Maksoud,

El-Tayeb

et al. 2024

Front. Immunol.

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“…Many living things, such as bacteria, fungus, yeast, algae, actinomycetes, and plant extracts from different plant parts, such as stem, root, fruit, seed, callus, peel, leaves, and flowers, may create metallic nanoparticles of different sizes and forms (Barabadi et al, 2019;Qamar & Ahmad 2021;Salem & Fouda,2021).A wide variety of metal concentrations and plant extract amounts in the reaction media can change a biosynthesis process, changing the shapes and sizes of the nanoparticles (Shreyash et al, 2021).Cadmium Oxide NPs have recently gained attention from researchers due to their significance, applications, and properties in biomedical applications like anti-bacterial and anti-fungal resistance to bacterial and fungal diseases, as well as optoelectronic devices like solar cells, optical transistors, glassy electrodes, gas sensors, and so forth (Singh et al,2020;Selvi and Sagadevan 2022). CdO nanostructure possesses anti-cancer effects due to its unique physicochemical features (Sagadevan et al, 2021;Shalaby et al, 2022). Phoenix roebelenii (Aldeen et al, 2020), tea leaf extracts (Mareedu et al, 2021), agathosma betulina leaf (Ghotekar, 2019), Aloe barbadensis miller extract (Somasundaram et al, 2019), and other plant extracts like Tinospora Cardifolia (stems), Rhododendron arboretum (flower) (Dixit, et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Phytosynthesis of Cadmium Oxides Nanoparticles by Crude Extract of Urtica Dioica

Abdulhadi,

Abdul Galill,

Abd

2023

UOD

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This study was identifying the flavonoids in Urtica dioica and using this extract to phytosynthesis of Cadmium oxides nanoparticles: CdO, CdO 2 with characterization about them. The results obtained from the HPLC analysis found nine compounds, which included: Rutin 26.14 % was most abundant, followed by Chlorogenic acid 22.2 %, Naringin, Meyrecetin, Quercetin, Kaempferol, Vanallic acid, Ellagic acid and Isorhamantin.Two procedures were used to phytosynthesis NPs. The results showed that their average size (calculated by AFM) were: (75.25 and 70.34) nm for procedure1and procedure 2, respectively. From SEM study, there were nanorods particles produced by procedure 1 with dimensions range less than 50 nm, in addition, to nano plate with one diminution lower than 50 nm. While in procedure 2, the particles were spherical nanoparticles crystals with nanorods their sizes were (˂ 25) nm. The same features were seen in TEM images. The FTIR results showed strong bands are observed at (524.6 and 501.5) cm-1 for procedure 1 and 2, respectively, which attributed to Cd-O stretching vibrations. The XRD patterns of each procedure produce a mixture of nanoparticles: CdO and CdO 2 . The average crystallite size of NPs was: (14.74 and 13.97) nm for procedure 1 respectively, and (16.8 and 13.9) nm, respectively. From UV visible spectral, the absorption spectra exhibit strong absorption at 290 nm and 300 nm for procedures (1 and 2), respectively. Their energy band gaps were: (3 and 4.4) eV, respectively.

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Tannic acid chitosan iron oxide nanocomposite for cervical cancer treatment

Barahuie,

Dorniani,

Saifullah

et al. 2024

Inorganic Chemistry Communications

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Structural, optical characteristics and Anti-Cancer effect of Cd0.99Ni0.01O nanoparticles on human neuroblastoma and cervical cancer cell lines

Cited by 5 publications

References 61 publications

Hesperidin - loaded PVA/alginate hydrogel: targeting NFκB/iNOS/COX-2/TNF-α inflammatory signaling pathway

Hesperidin - loaded PVA/alginate hydrogel: targeting NFκB/iNOS/COX-2/TNF-α inflammatory signaling pathway

Phytosynthesis of Cadmium Oxides Nanoparticles by Crude Extract of Urtica Dioica

Tannic acid chitosan iron oxide nanocomposite for cervical cancer treatment

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