Structural predictions of neurobiologically relevant G-protein coupled receptors and intrinsically disordered proteins

Rossetti, Giulia; Dibenedetto, Domenica; Calandrini, Vania; Giorgetti, Alejandro; Carloni, Paolo

doi:10.1016/j.abb.2015.03.011

Cited by 4 publications

(1 citation statement)

References 182 publications

(100 reference statements)

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“…ORs belong to the class A (rhodopsin-like) GPCR, however, crystal structure of the OR proteins has not yet been determined; thus, this is one of the most important tasks in understanding chemical sensation by ORs. The protein structure of these receptors has been deduced by homology modelling techniques with amino acid sequence analysis compared with known GPCR three dimensional structures [73][74][75][76][77][78][79][80] . Ligand binding is thought to take place in a pocket formed by the transmembrane helices.…”

Section: Nasal Olfactory Systemmentioning

confidence: 99%

Therapeutic potential of ectopic olfactory and taste receptors

Lee

Depoortere

Hatt

2018

Nat Rev Drug Discov

219

202

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Olfactory and taste receptors are expressed primarily in the nasal olfactory epithelium and gustatory taste bud cells, where they transmit real-time sensory signals to the brain. However, they are also expressed in multiple extra-nasal and extra-oral tissues, being involved in diverse biological processes including sperm chemotaxis, hypoxia sensing, inflammation, appetite regulation and energy metabolism. Elucidation of the physiological roles of these ectopic receptors is revealing potential therapeutic and diagnostic applications in diseases including wound healing, hair growth, asthma, obesity, and cancers. This review outlines current understanding of the diverse functions of ectopic olfactory and taste receptors and assesses their potential to be therapeutically exploited.

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Section: Nasal Olfactory Systemmentioning

confidence: 99%

Therapeutic potential of ectopic olfactory and taste receptors

Lee

Depoortere

Hatt

2018

Nat Rev Drug Discov

219

202

View full text Add to dashboard Cite

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The Dopaminergic System

2019

Chemical Biology of Neurodegeneration

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Molecular Dynamics Simulations: Principles and Applications for the Study of Membrane Proteins

Oakes¹,

Domene²

2016

Computational Biophysics of Membrane Proteins

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The plasma membrane is responsible for the maintenance of the correct chemical composition in cells, separating harmful substances from key biochemical processes required for basic human function. Membrane proteins are responsible for communication and transport phenomena across the membrane, facilitating a dynamic relationship between the cell interior and exterior despite the physical blockade. How these proteins function on a molecular level, however, remains largely unresolved. A fuller understanding is steadily emerging due to the increasing availability of three-dimensional structures of membrane proteins, in combination with computational methodologies such as molecular dynamics simulations. In this chapter, we present the key principles and considerations of performing molecular dynamics simulations in the context of membrane proteins, highlighting the leading applications in this field.

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Structural predictions of neurobiologically relevant G-protein coupled receptors and intrinsically disordered proteins

Cited by 4 publications

References 182 publications

Therapeutic potential of ectopic olfactory and taste receptors

Therapeutic potential of ectopic olfactory and taste receptors

The Dopaminergic System

Molecular Dynamics Simulations: Principles and Applications for the Study of Membrane Proteins

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