Structural preservation of deafferented cortex induced by electrical stimulation of a sensory peripheral nerve

Herrera-Rincon, Celia; Torets, Carlos; Sánchez‐Jiménez, Abel; Avendaño, Carlos; Guillén, Pedro; Panetsos, Fivos

doi:10.1109/iembs.2010.5626229

Cited by 5 publications

(4 citation statements)

References 8 publications

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“…The different effect of the neurostimulation on the trigeminal neuronal subtypes could explain central phenomena we have reported in previous works, namely that electrical stimulation protects against deafferentation-dependent degeneration of the somatosensory pathway but does not protect against the interruption of the cholinergic input to the somatosensory cortex (Herrera-Rincon et al, 2010a,b, 2012; Herrera-Rincon and Panetsos, 2014). Such an effect could be due to the different action of the electrical stimulation over the myelinated (TrkB and TrkC) neurons, projecting epicritically to thalamus and cortex, and the unmyelinated neurons (TrkA and IB4), projecting protopatically to the reticular system and basal prosencephalon.…”

Section: Resultsmentioning

confidence: 78%

Dependence of Neuroprosthetic Stimulation on the Sensory Modality of the Trigeminal Neurons Following Nerve Injury. Implications in the Design of Future Sensory Neuroprostheses for Correct Perception and Modulation of Neuropathic Pain

et al. 2019

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Amputation of a sensory peripheral nerve induces severe anatomical and functional changes along the afferent pathway as well as perception alterations and neuropathic pain. In previous studies we showed that electrical stimulation applied to a transected infraorbital nerve protects the somatosensory cortex from the above-mentioned sensory deprivation-related changes. In the present study we focus on the initial tract of the somatosensory pathway and we investigate the way weak electrical stimulation modulates the neuroprotective-neuroregenerative and functional processes of trigeminal ganglia primary sensory neurons by studying the expression of neurotrophins (NTFs) and Glia-Derived Neurotrophic Factors (GDNFs) receptors. Neurostimulation was applied to the proximal stump of a transected left infraorbitary nerve using a neuroprosthetic micro-device 12 h/day for 4 weeks in freely behaving rats. Neurons were studied by in situ hybridization and immunohistochemistry against RET (proto-oncogene tyrosine kinase “rearranged during transfection”), tropomyosin-related kinases (TrkA, TrkB, TrkC) receptors and IB4 (Isolectin B4 from Griffonia simplicifolia). Intra-group (left vs. right ganglia) and inter-group comparisons (between Control, Axotomization and Stimulation-after-axotomization groups) were performed using the mean percentage change of the number of positive cells per section [100 ∗ (left–right)/right)]. Intra-group differences were studied by paired t -tests. For inter-group comparisons ANOVA test followed by post hoc LSD test (when P < 0.05) were used. Significance level (α) was set to 0.05 in all cases. Results showed that (i) neurostimulation has heterogeneous effects on primary nociceptive and mechanoceptive/proprioceptive neurons; (ii) neurostimulation affects RET-expressing small and large neurons which include thermo-nociceptors and mechanoceptors, as well as on the IB4- and TrkB-positive populations, which mainly correspond to non-peptidergic thermo-nociceptive cells and mechanoceptors respectively. Our results suggest (i) electrical stimulation differentially affects modality-specific primary sensory neurons (ii) artificial input mainly acts on specific nociceptive and mechanoceptive neurons (iii) neuroprosthetic stimulation could be used to modulate peripheral nerve injuries-induced neuropathic pain. These could have important functional implications in both, the design of effective clinical neurostimulation-based protocols and the development of neuroprosthetic devices, controlling primary sensory neurons through selective neurostimulation.

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Section: Resultsmentioning

confidence: 78%

Dependence of Neuroprosthetic Stimulation on the Sensory Modality of the Trigeminal Neurons Following Nerve Injury. Implications in the Design of Future Sensory Neuroprostheses for Correct Perception and Modulation of Neuropathic Pain

et al. 2019

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“…For details about experimental procedures see [9]. Briefly, to evaluate an automatic image analysis system and to assess the restoring effects of BMIs on the amputated peripheral nerves, we compared intact nerves from rats without any peripheral manipulation (Control group) with experimental nerves o neuromas of rats with complete section of the trigeminal nerve (Amputated animals) and experimental nerves o neuromas of rats with complete section of the trigeminal nerve but to which a stimulating device was implanted immediately after the lesion (Prosthetic animals).…”

Section: A Surgery and Implantsmentioning

confidence: 99%

Effects of neuroprosthetic stimulation on the peripheral nerves of amputees: A digital image processing study

Herrera-Rincon

Cisneros

Castellanos

et al. 2011

2011 5th International IEEE/EMBS Conference on Neural Engineering

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In the present study we apply digital image processing techniques to evaluate the consequences of neuroprosthetic stimulation to the peripheral nerves of amputee subjects. The descriptors we employed (contrast, correlation, homogeneity and percentage of collagen and fibers) describe well the real conditions of the control and experimental nerves. Here we compare intact nerves from rats without any peripheral manipulation (control or C-group) with experimental nerves o neuromas of rats with complete section of the trigeminal nerve (amputated or A-group) and experimental nerves o neuromas of rats with complete section of the trigeminal nerve but stimulated for 4 weeks by means of a device implanted immediately after the lesion (prosthetic or Pgroup). Scores of the C, A and P groups indicate a normalizing tendency of P-conditions on the traumatic neuroma: P-C groups display more similar values than C-A or P-A. Our results are useful to obtain morphometric data of peripheral nerves, estimate changes in neuroma and clinical consequences due to amputations and electrical stimulation of the amputated peripheral nerves.

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“…In Figure 1 a schematic presentation of the experiment can be shown. More details on the experimental procedures are given in (Herrera-Rincon et al, 2010a , b ).…”

Section: The Role Of Artificially Induced Electric Fields In Neural Rmentioning

confidence: 99%

Combining BMI Stimulation and Mathematical Modeling for Acute Stroke Recovery and Neural Repair

Andino¹,

Herrera-Rincon²,

Panetsos³

et al. 2011

Front. Neurosci.

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Rehabilitation is a neural plasticity-exploiting approach that forces undamaged neural circuits to undertake the functionality of other circuits damaged by stroke. It aims to partial restoration of the neural functions by circuit remodeling rather than by the regeneration of damaged circuits. The core hypothesis of the present paper is that – in stroke – brain machine interfaces (BMIs) can be designed to target neural repair instead of rehabilitation. To support this hypothesis we first review existing evidence on the role of endogenous or externally applied electric fields on all processes involved in CNS repair. We then describe our own results to illustrate the neuroprotective and neuroregenerative effects of BMI-electrical stimulation on sensory deprivation-related degenerative processes of the CNS. Finally, we discuss three of the crucial issues involved in the design of neural repair-oriented BMIs: when to stimulate, where to stimulate and – the particularly important but unsolved issue of – how to stimulate. We argue that optimal parameters for the electrical stimulation can be determined from studying and modeling the dynamics of the electric fields that naturally emerge at the central and peripheral nervous system during spontaneous healing in both, experimental animals and human patients. We conclude that a closed-loop BMI that defines the optimal stimulation parameters from a priori developed experimental models of the dynamics of spontaneous repair and the on-line monitoring of neural activity might place BMIs as an alternative or complement to stem-cell transplantation or pharmacological approaches, intensively pursued nowadays.

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Structural preservation of deafferented cortex induced by electrical stimulation of a sensory peripheral nerve

Cited by 5 publications

References 8 publications

Dependence of Neuroprosthetic Stimulation on the Sensory Modality of the Trigeminal Neurons Following Nerve Injury. Implications in the Design of Future Sensory Neuroprostheses for Correct Perception and Modulation of Neuropathic Pain

Dependence of Neuroprosthetic Stimulation on the Sensory Modality of the Trigeminal Neurons Following Nerve Injury. Implications in the Design of Future Sensory Neuroprostheses for Correct Perception and Modulation of Neuropathic Pain

Effects of neuroprosthetic stimulation on the peripheral nerves of amputees: A digital image processing study

Combining BMI Stimulation and Mathematical Modeling for Acute Stroke Recovery and Neural Repair

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