Structural properties of scaffolds: Crucial parameters towards stem cells differentiation

Ghasemi‐Mobarakeh, Laleh; Prabhakaran, Molamma P.; Tian, Lingling; Shamirzaei-Jeshvaghani, Elham; Dehghani, Leila; Ramakrishna, Seeram

doi:10.4252/wjsc.v7.i4.728

Cited by 181 publications

(129 citation statements)

References 110 publications

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“…50 The mechanical properties of biomaterials, such as electrospun PMMtissue scaffolds, should be in an appropriate range considering their intended applications. 51 The mucilage, as an organic additive material, might induce a positive effect on the tensile strength of PVA nanofibers. 52 Therefore, the mechanical properties of PMM/PVA nanofibers were investigated in order to determine the effect of PMM on pure PVA nanofiber tensile strength.…”

Section: Tensile Strengthmentioning

confidence: 99%

Fabrication and characterization of electrospun Plantago major seed mucilage/PVA nanofibers

Golkar

Kalani

Allafchian

et al. 2019

J of Applied Polymer Sci

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Electrospinning is a well‐known technique for producing nanofibers using synthetic and natural polymers like mucilage. In this study, Plantago major Mucilage (PMM) was blended with polyvinyl alcohol (PVA) as a nontoxic adding agent, in order to produce electrospun nanofiber. Electrospinning parameters (voltage, tip‐to‐collector distance, feed rate, and PMM/PVA ratio) were optimized and solution properties were analyzed. The morphology of nanofibers was investigated using scanning electron microscopy (SEM), Fourier transform infrared (FTIR), X‐ray diffraction (XRD), and Brunauer–Emmett–Teller (BET). Mechanical strength of nanofibers was determined, and cell viability on nanofibers was discussed by MTT assay. The results of SEM indicated that the PMM/PVA (50/50) nanofibers obtained with average diameter of 250 nm. Viscosity, electrical conductivity, and surface tension of PMM/PVA solution were 550 Cp, 575 μS/cm, and 47.044 mN/m, respectively. FTIR and XRD results verified the exiting PMM in produced nanofibers and no chemical reaction between PMM and PVA. Improvement in mechanical strength and cell viability of nanofibers by adding PMM to PVA nanofibers indicated the potential application of PMM‐based nanofibers for medical and food industries. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47852.

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Section: Tensile Strengthmentioning

confidence: 99%

Fabrication and characterization of electrospun Plantago major seed mucilage/PVA nanofibers

Golkar

Kalani

Allafchian

et al. 2019

J of Applied Polymer Sci

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“…The typical tissue engineering approach uses a biomaterial scaffold seeded with cells and bioactive factors. By optimizing properties of the scaffold such biocompatibility, biodegradability, porosity, mechanical properties, topography, and biochemical signaling, an extracellular environment can be created that mimics in vivo tissue and positively influences cell proliferation, differentiation, migration, and long‐term engraftment . Studies have already demonstrated the feasibility of pericyte‐based tissue engineered vascular grafts for treatment of limb ischemia , and animal models using similar cell sources have shown promising results for cardiac repair using scaffold‐based cell delivery .…”

Section: Utilizing Pericytes For Regenerative Therapymentioning

confidence: 99%

Concise Review: The Regenerative Journey of Pericytes Toward Clinical Translation

et al. 2018

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Coronary artery disease (CAD) is the single leading cause of death worldwide. Advances in treatment and management have significantly improved patient outcomes. On the other hand, although mortality rates have decreased, more people are left with sequelae that require additional treatment and hospitalization. Moreover, patients with severe nonrevascularizable CAD remain with only the option of heart transplantation, which is limited by the shortage of suitable donors. In recent years, cell‐based regenerative therapy has emerged as a possible alternative treatment, with several regenerative medicinal products already in the clinical phase of development and others emerging as competitive preclinical solutions. Recent evidence indicates that pericytes, the mural cells of blood microvessels, represent a promising therapeutic candidate. Pericytes are abundant in the human body, play an active role in angiogenesis, vessel stabilization and blood flow regulation, and possess the capacity to differentiate into multiple cells of the mesenchymal lineage. Moreover, early studies suggest a robustness to hypoxic insult, making them uniquely equipped to withstand the ischemic microenvironment. This review summarizes the rationale behind pericyte‐based cell therapy and the progress that has been made toward its clinical application. We present the different sources of pericytes and the case for harvesting them from tissue leftovers of cardiovascular surgery. We also discuss the healing potential of pericytes in preclinical animal models of myocardial ischemia (MI) and current practices to upgrade the production protocol for translation to the clinic. Standardization of these procedures is of utmost importance, as lack of uniformity in cell manufacturing may influence clinical outcome. Stem Cells 2018;36:1295–1310

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“…Mechanical properties such as tensile strength and compliance are important to the compatibility of the fiber with the weaving machine and maintenance of the desired scaffold shape. Material properties such as hydrophobicity and degradability are important considerations that will affect cellular behavior once cells have been seeded onto the construct …”

Section: Bio‐loom To Weave Scaffolds For Bone Tissue Engineeringmentioning

confidence: 99%

“…Material properties such as hydrophobicity and degradability are important considerations that will affect cellular behavior once cells have been seeded onto the construct. 9 Given the unique qualities of absorbable materials when compared with traditional threads, special consideration must be given to weaving these fibers. The term bio-loom can be defined as a textile technology-based apparatus, specialized for the weaving of absorbable fibers or yarns.…”

Section: Bio-loom To Weave Scaffolds For Bone Tissue Engineeringmentioning

confidence: 99%

Design and optimization of a novel bio‐loom to weave melt‐spun absorbable polymers for bone tissue engineering

et al. 2016

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Bone graft procedures are currently among the most common surgical procedures performed worldwide, but due to high risk of complication and lack of viable donor tissue, there exists a need to develop alternatives for bone defect healing. Tissue engineering, for example, combining biocompatible scaffolds with mesenchymal stem cells to achieve new bone growth, is a possible solution. Recent work has highlighted the potential for woven polymer meshes to serve as bone tissue engineering scaffolds; since, scaffolds can be iteratively designed by adjusting weave settings, material types, and mesh parameters. However, there are a number of material and system challenges preventing the implementation of such a tissue engineering strategy. Fiber compliance, tensile strength, brittleness, cross-sectional geometry, and size present specific challenges for using traditional textile weaving methods. In the current work, two potential scaffold materials, melt-spun poly-l-lactide, and poly-l-lactide-co-ε-caprolactone, were investigated. An automated bio-loom was engineered and built to weave these materials. The bio-loom was used to successfully demonstrate the weaving of these difficult-to-handle fiber types into various mesh configurations and material combinations. The dobby-loom design, adapted with an air jet weft placement system, warp tension control system, and automated collection spool, provides minimal damage to the polymer fibers while overcoming the physical constraints presented by the inherent material structure. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1342-1351, 2017.

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Structural properties of scaffolds: Crucial parameters towards stem cells differentiation

Cited by 181 publications

References 110 publications

Fabrication and characterization of electrospun Plantago major seed mucilage/PVA nanofibers

Fabrication and characterization of electrospun Plantago major seed mucilage/PVA nanofibers

Concise Review: The Regenerative Journey of Pericytes Toward Clinical Translation

Design and optimization of a novel bio‐loom to weave melt‐spun absorbable polymers for bone tissue engineering

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