Structural Proteins of HCV and Biological Functions

Moriishi, Kohji; Matsuura, Yoshiharu

doi:10.1007/978-4-431-56098-2_6

Cited by 4 publications

(4 citation statements)

References 163 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…45 Its genome is located inside a nucleocapsid, which is surrounded by a lipid bilayer membrane envelope with two subunits of viral glycoproteins (E1 and E2) that have important roles in viral entry. 45,46 In 2019, the WHO estimated that at least 58 million people worldwide contracted chronic hepatitis C, in which 290,000 of them died mostly due to end-stage liver diseases, including cirrhosis and HCC. 47 According to the data collected in 2013, approximately 2.5% of Indonesia's total population were infected with HCV.…”

Section: Hepatitis C Virusmentioning

confidence: 99%

Severe Acute Hepatitis of Unknown Etiology in Indonesia: What Has Been Learned?

Hokinson¹,

Sanjaya²,

Jo³

2022

Explor Res Hypothesis Med

View full text Add to dashboard Cite

The world has witnessed increased incidences of severe acute hepatitis in children since early 2021, in which the total number of global cases was over 1,000 in July 2022. Those cases of severe acute hepatitis were intriguing, as they were not caused by the common hepatitis A-E viruses. Additionally, the cause remains unknown to date, thus named as severe acute hepatitis of unknown etiology. The World Health Organization, supported by regional and national health agencies, has issued the working case definitions in order to closely monitor the development of this disease worldwide. As one of its member states, Indonesia has also adopted the case definitions and subsequently issued a health decree to increase public awareness and to conduct an early surveillance on this illness. It remains to be seen whether this updated public health policy would be successful to control the numbers of cases of severe acute hepatitis of unknown etiology in Indonesia.

show abstract

Section: Hepatitis C Virusmentioning

confidence: 99%

Severe Acute Hepatitis of Unknown Etiology in Indonesia: What Has Been Learned?

Hokinson¹,

Sanjaya²,

Jo³

2022

Explor Res Hypothesis Med

View full text Add to dashboard Cite

show abstract

“…It has an icosahedra nucleocapsid, which is bordered by a phospholipid bilayer membrane and contains two glycol-proteins known as (E1) envelope one and (E2) envelope two proteins, and an RNA positive strand with a length of around 9.6 kb. 1 Commonly, the frequent routes for spread of HCV infection are through transfer of small amounts of contaminated blood between people. This occurs via unsafe injection practices, unsafe health care, and transfusion of unscreened blood.…”

Section: Introductionmentioning

confidence: 99%

Sero-prevalence of Hepatitis C virus infection in patients undergoing haemodialysis in Al-Najaf Province

Khalida Abbas Al Kelaby,

Qabas Neamah Hadi Al Hajjar,

Ghaith Kadhim Al Azam

2023

J Pak Med Assoc

View full text Add to dashboard Cite

This study identified the predominance of HCV in patients undergoing haemodialysis and the risk factors related to age, gender, residence and occupation. It was conducted in the haemodialysis centre in Al-Saddar hospital in Al-Najaf province. A total of 193 patients were enrolled. Blood was drawn for testing HCV antibodies using ELISA. A positive result for presence of antibodies confirmed HCV infection. Of 193 patients studied, 43(22.3%) were infected with HCV. The higher frequency of infection was in the age group 31- 50 years (11.4%). The rate of HCV in women was (22.89%), while in men it was (21.81%) which was an insignificant difference. Continue....

show abstract

“…Translation of the viral RNA leads to the synthesis of a polyprotein, which is processed into individual viral proteins via cleavages of both cellular and viral proteases. The structural proteins (i.e., the core and envelope glycoproteins E1 and E2) are the main constituents of HCV particles, whereas the viroporin p7 and nonstructural protein 2 (NS2) are involved in virion assembly [ 6 ]. The remaining nonstructural proteins (i.e., NS3, NS4A, NS4B, NS5A, and NS5B; NS3-NS5B) that have specific roles in viral genome amplification form the replication complex [ 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Hepatitis C Viral Replication Complex

Yang

2021

Viruses

View full text Add to dashboard Cite

The life cycle of the hepatitis C virus (HCV) can be divided into several stages, including viral entry, protein translation, RNA replication, viral assembly, and release. HCV genomic RNA replication occurs in the replication organelles (RO) and is tightly linked to ER membrane alterations containing replication complexes (proteins NS3 to NS5B). The amplification of HCV genomic RNA could be regulated by the RO biogenesis, the viral RNA structure (i.e., cis-acting replication elements), and both viral and cellular proteins. Studies on HCV replication have led to the development of direct-acting antivirals (DAAs) targeting the replication complex. This review article summarizes the viral and cellular factors involved in regulating HCV genomic RNA replication and the DAAs that inhibit HCV replication.

show abstract

Structural Proteins of HCV and Biological Functions

Cited by 4 publications

References 163 publications

Severe Acute Hepatitis of Unknown Etiology in Indonesia: What Has Been Learned?

Severe Acute Hepatitis of Unknown Etiology in Indonesia: What Has Been Learned?

Sero-prevalence of Hepatitis C virus infection in patients undergoing haemodialysis in Al-Najaf Province

Hepatitis C Viral Replication Complex

Contact Info

Product

Resources

About