Structural reactions of the buccal mucosa in diabetic parodontopathy

Balakhonov, L V; Nepomnyashchikh, L. M.; Айдагулова, С. В.; Bakarev, M. A.; Vlasova, L. F.

doi:10.1007/s10517-006-0436-1

Cited by 4 publications

(4 citation statements)

References 5 publications

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“…The interstitial collagen sclerosis with thick collagen bands forming have been often associated with overlying epithelium atrophy, interpapillary ridges removal, straightening of epithelium-chorion limit and also vascular sclerosis. Patients with a DM history of 5 to 15 years and/or mostly atrophic alterations presents subepithelial capillary sclerosis and an important stromal sclerosis [14].…”

Section: Resultsmentioning

confidence: 99%

Histological Analysis of Collagen Fibers in Patients with Diabetes Mellitus and Periodontal Disease

Popescu¹

2014

J Cytol Histol

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The researchers suggest that diabetes increases the degradation of the newly synthesized collagen from the conjunctive tissue. The altered metabolism of the collagen may predispose the diabetic patients not only to periodontal disease, but also to some other anomalies such as defective healing. The purpose of the study was to go through a histological analysis of the collagen fibers from the chorion in patients with diabetes mellitus and periodontal disease. Materials and methods:In our study we examined a total of 68 patients diagnosed with diabetes mellitus type 1 and 2. In these patients we achieved simple gingivectomy or tooth extraction in order to obtain gingival tissue fragments. The preparations included at paraffin and then stained with Hematoxylin-Eosin and trichromic after Goldner-Szeckeli method. Results:In the patients with diabetes mellitus with an evolution of less than 10 years the collagen fibers appeared as dissociated by the inflammatory cells that were inserted among them. It was also noted the fragmentation of collagen fibers and sometimes even their lysis with subepithelial connective tissue disorganization. In patients with diabetes for over 10 years there has been noticed a plentiful collagen sclerosis, zones of collagen hyalinization with an increased number of fibrocytes. Conclusion:The extracellular matrix is altered in the investigated patients with destructive lesions of collagen or collagen sclerosis.

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Section: Resultsmentioning

confidence: 99%

Histological Analysis of Collagen Fibers in Patients with Diabetes Mellitus and Periodontal Disease

Popescu¹

2014

J Cytol Histol

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“…Mucosal biopsy of diabetic patients with disease history of 5-15 years, presented thinned mucosa of the alveolar process, reduced and sclerosed sub epithelial capillaries, and atrophy of the multilamellar squamous epithelium. 22 A study by Hata et al revealed that the gingival epithelium thickness in diabetic rats were thinner than normal rats and epithelial ridges were nearly absent in the diabetes group. This is thought to be the result of metabolic disturbances which are most pronounced in the basal layers where cell division are active.…”

Section: Discussionmentioning

confidence: 98%

Psychological Stress and Diabetes Mellitus As Complicating Factors in Management of Pemphigus Vulgaris

Ramadian

Sarsito

2017

UIP HEATH MED

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Introduction: Pemphigus vulgaris (PV) is an autoimmune disease with vesiculobullous lesions that attack the skin and mucosa including oral mucosa. There are some factors that can trigger the recurrence of PV; one of them is psychological stress. PV is treated using immunosuppressant agents like corticosteroids or other immunosuppressant drugs. Complete remission in PV often hard to achieve because of some trigger factors that is hard to control and systemic disease like diabetes mellitus (DM).

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“…Patients with diabetes are prone to developing oral complications such as caries (Bender & Bender 2003, Zhen et al 2010, Sano et al 2011, pulp and periapical pathosis (Bender & Bender 2003, Fouad 2003b, Iwama et al 2006, Segura-Egea et al 2012) and especially periodontal disease (Arrieta-Blanco et al 2003, Fouad 2003b, Balakhonov et al 2006, Iwama et al 2006, Wang et al 2006, Garber et al 2009, Lecka-Czernik 2010, Negrato & Tarzia 2010, Al-Maskari et al 2011, Eldarrat 2011, considered as the sixth most chronic DM complication (Negrato & Tarzia 2010, Al-Maskari et al 2011. Oral infections are reported with higher prevalence and severity in uncontrolled type 1 DM (Bender & Bender 2003).…”

Section: Pathology Of Dmmentioning

confidence: 99%

“…It is a chronic, complex, progressive and debilitating disease that at the moment has no cure and is characterized by partial or total deficiency in insulin production (Bender & Bender 2003). As a consequence, this disease promotes hyperglycaemia (Fouad 2003b, Wittrant et al 2008, Dienelt & zur Nieden 2011, wound healing difficulties (Balakhonov et al 2006, Hamada et al 2007, Garber et al 2009), as well as systemic and oral manifestations (Fouad 2003b, Catanzaro et al 2006, Negrato & Tarzia 2010, Al-Maskari et al 2011, Eldarrat 2011.…”

Section: Introductionmentioning

confidence: 99%

Diabetes mellitus and inflammatory pulpal and periapical disease: a review

et al. 2013

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Diabetes mellitus (DM) is one of the most common metabolic disorders. DM is characterized by hyperglycaemia, resulting in wound healing difficulties and systemic and oral manifestations, which have a direct effect on dental pulp integrity. Experimental and clinical studies have demonstrated a higher prevalence of periapical lesions in patients with uncontrolled diabetes. The influence of DM on periapical bone resorption and its impact on dental intervention of such patients are reviewed, and its aetiology and pathogenesis are analysed at molecular level. Pulps from patients with diabetes have the tendency to present limited dental collateral circulation, impaired immune response, increased risk of acquiring pulp infection (especially anaerobic ones) or necrosis, besides toothache and occasional tendency towards pulp necrosis caused by ischaemia. In regard to molecular pathology, hyperglycaemia is a stimulus for bone resorption, inhibiting osteoblastic differentiation and reducing bone recovery. The relationship between poorly controlled diabetes and bone metabolism is not clearly understood. Molecular knowledge about pulp alterations in patients with diabetes could offer new therapeutic directions. Knowledge about how diabetes affects systemic and oral health has an enduring importance, because it may imply not only systemic complications but also a higher risk of oral diseases with a significant effect on pulp and periapical tissue.

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Structural reactions of the buccal mucosa in diabetic parodontopathy

Cited by 4 publications

References 5 publications

Histological Analysis of Collagen Fibers in Patients with Diabetes Mellitus and Periodontal Disease

Histological Analysis of Collagen Fibers in Patients with Diabetes Mellitus and Periodontal Disease

Psychological Stress and Diabetes Mellitus As Complicating Factors in Management of Pemphigus Vulgaris

Diabetes mellitus and inflammatory pulpal and periapical disease: a review

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